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Themed collection Toxicology Research 2017 Most Downloaded Articles

10 items
Open Access Viewpoint

Making the most of expert judgment in hazard and risk assessment of chemicals

Expert judgment is a critical and inherent part of evaluating evidence for hazard and risk assessment of chemicals. Approaches like SciRAP promote structured and transparent application of evaluators' expertise in this process.

Graphical abstract: Making the most of expert judgment in hazard and risk assessment of chemicals
Review Article

Toxic mechanisms of microcystins in mammals

This review discusses mechanisms of toxicity, particularly those observed in liver tissue, mediated by microcystins (MCs) produced by cyanobacteria.

Graphical abstract: Toxic mechanisms of microcystins in mammals
From the themed collection: Recent HOT articles
Review Article

Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles

Titanium dioxide nanoparticles (TiO2 NPs) are inorganic materials with a diameter of 1–100 nm.

Graphical abstract: Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles
From the themed collection: Recent Review Articles
Open Access Paper

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.

Graphical abstract: Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
Open Access Paper

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.

Graphical abstract: Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
Paper

Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation

Because air pollution is a complex mixture of pollutants, understanding the health risks requires an evaluation of their combined effects rather than predictions based on the single chemicals alone.

Graphical abstract: Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation
From the themed collection: Recent HOT articles
Open Access Paper

Prediction of the effect of formulation on the toxicity of chemicals

Two approaches for the prediction of which of two vehicles will result in lower toxicity for anticancer agents are presented.

Graphical abstract: Prediction of the effect of formulation on the toxicity of chemicals
Paper

Modelling compound cytotoxicity using conformal prediction and PubChem HTS data

The assessment of compound cytotoxicity is an important part of the drug discovery process.

Graphical abstract: Modelling compound cytotoxicity using conformal prediction and PubChem HTS data
Paper

Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans

Organophosphate flame retardants (PFRs) induce neurotoxic effects.

Graphical abstract: Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans
Paper

Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach

Pyrazinamide disturbed the metabolic profiles of rats with gender difference, with regard to metabolic pathways related to its hepatotoxicity.

Graphical abstract: Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach
From the themed collection: Recent HOT articles
10 items

About this collection

This themed collection features the top 10 most downloaded articles published in Toxicology Research in 2017. Congratulations to all of the authors whose articles have been featured.

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