SCHEDULED MAINTENANCE
Viewpoint
Making the most of expert judgment in hazard and risk assessment of chemicals
Expert judgment is a critical and inherent part of evaluating evidence for hazard and risk assessment of chemicals. Approaches like SciRAP promote structured and transparent application of evaluators' expertise in this process.
Toxic mechanisms of microcystins in mammals
This review discusses mechanisms of toxicity, particularly those observed in liver tissue, mediated by microcystins (MCs) produced by cyanobacteria.
Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles
Titanium dioxide nanoparticles (TiO2 NPs) are inorganic materials with a diameter of 1–100 nm.
Paper
Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.
Paper
Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.
Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation
Because air pollution is a complex mixture of pollutants, understanding the health risks requires an evaluation of their combined effects rather than predictions based on the single chemicals alone.
Paper
Prediction of the effect of formulation on the toxicity of chemicals
Two approaches for the prediction of which of two vehicles will result in lower toxicity for anticancer agents are presented.
Modelling compound cytotoxicity using conformal prediction and PubChem HTS data
The assessment of compound cytotoxicity is an important part of the drug discovery process.
Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans
Organophosphate flame retardants (PFRs) induce neurotoxic effects.
Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach
Pyrazinamide disturbed the metabolic profiles of rats with gender difference, with regard to metabolic pathways related to its hepatotoxicity.
About this collection
This themed collection features the top 10 most downloaded articles published in Toxicology Research in 2017. Congratulations to all of the authors whose articles have been featured.