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Themed collection Spotlight on Systems Toxicology

4 items
Review Article

Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis

Allergic contact dermatitis (ACD) is a widespread hypersensitivity reaction of the skin. While technically still challenging in the context of ACD, proteomics provide a powerful and useful tool to study the underlying molecular mechanisms as well as for the identification of biomarkers.

Graphical abstract: Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis
From the themed collection: Recent Review Articles
Open Access Paper

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.

Graphical abstract: Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
Open Access Paper

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

A method of predicting drug-induced Torsade de Pointes risk based on the occurrence of simulated early after depolarisations.

Graphical abstract: Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
From the themed collection: Spotlight on Systems Toxicology
Open Access Paper

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.

Graphical abstract: Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
4 items

About this collection

Systems toxicology, which forms a subdivision of systems biology and was pioneered by Leroy Hood, has many definitions, but as a framework for hypothesis generation and testing may represent an important new way of explaining, modelling and predicting the consequences of the exposure of organisms to toxins. Here we highlight work in this area of research that can cover a wide span of topics, from mathematical in silico models, more descriptive "omics"-based approaches (genomics, transcriptomics, proteomics, metabonomics, etc.), to developing a systems view of toxicity.

Spotlight

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