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Themed collection Most accessed Toxicology Research articles in 2016

31 articles
Open Access Comment

Comment on “Promising blood-derived biomarkers for estimation of the postmortem interval” by I. Costa, F. Carvalho, T. Magalhães, P. G. de Pinho, R. Silvestre & R. J. Dinis-Oliveira. (Toxicol. Res., 2015, 4, 1443–1452)

Review Article

Mycotoxins: cytotoxicity and biotransformation in animal cells

Mycotoxins can be biotransformed by phase I and phase II enzymes in animals. However, most of the mycotoxin at high dosage combined with their metabolites can cause carcinogenesis and various cytotoxicity, such as apoptosis, lipids oxidation and cell cycle arrest, etc., and most of which are related to oxidative stress.

Graphical abstract: Mycotoxins: cytotoxicity and biotransformation in animal cells
From the themed collection: Recent Review Articles
Review Article

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review

Organisms respond to exogenous threats and insults by a potent inflammatory and immune response, aimed at preserving tissue integrity and restoring tissue homeostasis and function.

Graphical abstract: Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
From the themed collection: Recent Review Articles
Open Access Paper

Characterization of a functional C3A liver spheroid model

We have developed a method for creating C3A liver spheroids and demonstrated cellular polarisation, zonation as well as increased liver-specific functionality and more predictive toxicological response compared to standard 2D liver models.

Graphical abstract: Characterization of a functional C3A liver spheroid model
From the themed collection: Recent HOT articles
Open Access Paper

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons

Our data represent the first demonstration that oxy-PAHs can be potent inhibitors of CYP1 expression and function.

Graphical abstract: Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
From the themed collection: Recent HOT articles
Open Access Paper

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data

Using three descriptor domains – encoding complementary bioactivity data – enhances the predictive power, applicability, and interpretability of rat acute-toxicity classifiers.

Graphical abstract: Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Open Access Paper

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Acetaminophen (APAP) is possibly the most widely used medication globally and yet little is known of its molecular effects at therapeutic doses.

Graphical abstract: Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Paper

1H NMR-based urine metabolomics for the evaluation of kidney injury in Wistar rats by 3-MCPD

The cause of toxicity induced by 3-chloro-1,2-propanediol (3-MCPD) remains under investigation, and progress towards understanding this toxicity has been limited by the lack of sensitive and reliable biomarkers.

Graphical abstract: 1H NMR-based urine metabolomics for the evaluation of kidney injury in Wistar rats by 3-MCPD
Paper

The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells

The toxicity of multi-component mixtures of B[a]P and heavy metal/loid(s) was determined in HepG2 cells. Concentration dependent synergism, additivity or antagonism was predicted by the combination-index isobologram method.

Graphical abstract: The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells
Paper

Epigenetic toxicity of trichloroethylene: a single-molecule perspective

The volatile, water soluble trichloroethylene (TCE) is a hazardous industrial waste and could lead to various health problems through disrupting the interaction between DNA and epigenetic enzymes.

Graphical abstract: Epigenetic toxicity of trichloroethylene: a single-molecule perspective
Paper

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos

Silica nanoparticle-induced toxicity in zebrafish embryos affected expression of 2515 genes. Pathway analysis and Signal-net analysis indicated that the gap junction, vascular smooth muscle contraction, and metabolic pathways, apoptosis, the MAPK signaling pathway, the calcium signaling pathway and the JAK-STAT signaling pathway were the most prominent significant pathways in SiNP-induced toxicity in zebrafish embryos.

Graphical abstract: Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos
Paper

Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration

AgNPs cause toxic damage by gradually imposing stress impacts on the target organs in mice.

Graphical abstract: Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration
Paper

In silico prediction of hERG potassium channel blockage by chemical category approaches

A series of models of hERG blockage were built using five machine learning methods based on 13 molecular descriptors, five types of fingerprints and molecular descriptors combining fingerprints at four blockage thresholds.

Graphical abstract: In silico prediction of hERG potassium channel blockage by chemical category approaches
Paper

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies

New technologies launch novel materials; besides their performances in products, their health hazards must be tested.

Graphical abstract: Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Paper

Modeling the toxicity of chemical pesticides in multiple test species using local and global QSTR approaches

The figures show performance of the ensemble learning based global QSTR models in predicting the toxicities of pesticides in multiple test species.

Graphical abstract: Modeling the toxicity of chemical pesticides in multiple test species using local and global QSTR approaches
Paper

Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells – implications for tendon engineering

The first study evaluating the full range of dose–response relationships between decahedral silver nanoparticles and rat tendon-derived stem cells.

Graphical abstract: Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells – implications for tendon engineering
Paper

Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells

Benzo(a)pyrene (B[a]P) is a common environmental and foodborne pollutant which has been identified as a Group I carcinogen. And the global metabolic effects of long-term B[a]P exposure at low dosage were investigated.

Graphical abstract: Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
From the themed collection: Recent HOT articles
Paper

Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration

Zn2+ doping enhanced the magnetic susceptibility and stability of Zn0.4Fe2.6O4 NPs and attenuated Zn0.4Fe2.6O4 NP toxicity in mice.

Graphical abstract: Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration
Paper

Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions

Titanium dioxide (TiO2) nanomaterials (NMs) have been widely used to develop commercial products such as sunscreen cosmetics because of their unique optical properties to provide complete protection from ultraviolet (UV) light.

Graphical abstract: Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions
Paper

Intravenous injection of L-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson–dementia complex

Non-protein amino acid beta-N-methylamino-L-alanine (L-BMAA) is a neurotoxin that was associated with the high incidence of Amyotrophic Lateral Sclerosis/Parkinson–Dementia Complex (ALS/PDC) in Guam.

Graphical abstract: Intravenous injection of l-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson–dementia complex
From the themed collection: Alzheimer's Research Month 2016
Paper

Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats

Currently, drug-induced nephrotoxicity is widespread and seriously affects human health.

Graphical abstract: Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats
Paper

Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility

Multi-walled carbon nanotubes (MWCNTs) are beneficial in a wide range of applications in fields such as electronics, optics and nano-medicine, so knowledge concerning their effect on human health is important.

Graphical abstract: Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility
Paper

Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice

Grape seed proanthocyanidin extract (GSPE) is a rich source of proanthocyanidins with multiple biological activities and potential health benefits.

Graphical abstract: Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice
Paper

Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway

It has been reported that massive levels or/and high frequency exposure of diethylnitrosamine could induce hepatic neoplasm.

Graphical abstract: Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway
Paper

In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells

Iron oxide nanoparticles (ION) have been widely used in biomedical applications, for both diagnosis and therapy, due to their unique magnetic properties.

Graphical abstract: In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells
Paper

miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo

We compared OTA hepatotoxicity in vivo and in vitro. miR-122 regulated the CCNG1/p53 pathway in OTA-induced hepatocyte apoptosis. miR-122 also regulated the Bcl-w/caspase-3 pathway in OTA-induced hepatocyte apoptosis.

Graphical abstract: miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo
Paper

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways

The development of therapeutic approaches combining efficacy and safety represents an important goal in intestinal inflammation research.

Graphical abstract: Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
From the themed collection: Recent HOT articles
Paper

Cytotoxic effects of aspartame on human cervical carcinoma cells

In the present study we determined the effects of aspartame at various concentrations on cell viability, morphology, ROS level and DNA in human cervical carcinoma cells over different exposure periods.

Graphical abstract: Cytotoxic effects of aspartame on human cervical carcinoma cells
From the themed collection: Recent HOT articles
Paper

Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo

Schematic showing the toxicological and adaptive effects of drug-induced respiratory chain inhibition in vivo; also highlighting unanticipated differences from observations made in vitro (in red).

Graphical abstract: Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo
Paper

Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy

The effectiveness of NMR spectroscopy is demonstrated for the characterisation of Molecular Initiating Events in TT21C-aligned approaches to risk assessments.

Graphical abstract: Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy
From the themed collection: Recent HOT articles
Paper

Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures

Three-dimensional hAD-MSCs spheroid cultures, with the ability to resemble closely in vivo tissue structures, were assessed for evaluation of dose-dependent cytotoxicity effects of CdTe/CdS/ZnS quantum dots.

Graphical abstract: Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures
31 articles

About this collection

This themed collection features the top 30 most downloaded articles published in Toxicology Research in 2016. Congratulations to all of the authors whose articles have been featured.

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