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Themed collection Recent Review Articles

31 items
Viewpoint

The dangers of hazards

Concerns about the quality and reproducibility of scientific papers have emphasised the uncertainty of observations in the biological sciences.

Graphical abstract: The dangers of hazards
From the themed collection: Recent Review Articles
Viewpoint

Emerging toxicity models from emerging scientists

Emerging scientists joining the field of Toxicology bring with them novel and exciting approaches and models to assess toxicity.

Graphical abstract: Emerging toxicity models from emerging scientists
From the themed collection: Recent Review Articles
Review Article

Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health

This review provides an overview of the effects of supplements containing phytoestrogens on hormone levels and potential implications for women's health.

Graphical abstract: Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health
From the themed collection: Recent Review Articles
Review Article

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

o-Quinones are formed metabolically from natural and synthetic estrogens as well as upon exposure to polycyclic aromatic hydrocarbons (PAH) and contribute to estrogen and PAH carcinogenesis by genotoxic mechanisms.

Graphical abstract: Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification
From the themed collection: Recent Review Articles
Review Article

The ABCs of pesticide toxicology: amounts, biology, and chemistry

Everyone is affected directly or indirectly by pesticide use and safety.

Graphical abstract: The ABCs of pesticide toxicology: amounts, biology, and chemistry
From the themed collection: Recent Review Articles
Review Article

Toxicological effects of patulin mycotoxin on the mammalian system: an overview

The mycotoxin PAT (4-hydroxy-4H-furo[3,2c]pyran-2[6H]-one) is a secondary metabolic product of molds such as Penicillium, Aspergillus, and Byssochlamys species. Model depicting the cellular and biochemical events involved in PAT-induced toxicity.

Graphical abstract: Toxicological effects of patulin mycotoxin on the mammalian system: an overview
From the themed collection: Recent Review Articles
Review Article

Cytotoxicological pathways induced after nanoparticle exposure: studies of oxidative stress at the ‘nano–bio’ interface

This review focuses on the most common toxicological pathways induced by nanoparticle exposure.

Graphical abstract: Cytotoxicological pathways induced after nanoparticle exposure: studies of oxidative stress at the ‘nano–bio’ interface
From the themed collection: Recent Review Articles
Review Article

Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis

Allergic contact dermatitis (ACD) is a widespread hypersensitivity reaction of the skin. While technically still challenging in the context of ACD, proteomics provide a powerful and useful tool to study the underlying molecular mechanisms as well as for the identification of biomarkers.

Graphical abstract: Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis
From the themed collection: Recent Review Articles
Review Article

Toxic mechanisms of microcystins in mammals

This review discusses mechanisms of toxicity, particularly those observed in liver tissue, mediated by microcystins (MCs) produced by cyanobacteria.

Graphical abstract: Toxic mechanisms of microcystins in mammals
From the themed collection: Recent Review Articles
Review Article

Toxicological implications of mitochondrial localization of CYP2E1

This review discusses links between mitochondria-localized cytochrome P450 2E1 (CYP2E1) and toxicity, particularly mitochondrial dysfunction, and poses open questions in this emerging field.

Graphical abstract: Toxicological implications of mitochondrial localization of CYP2E1
From the themed collection: Recent Review Articles
Review Article

Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles

Titanium dioxide nanoparticles (TiO2 NPs) are inorganic materials with a diameter of 1–100 nm.

Graphical abstract: Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles
From the themed collection: Recent Review Articles
Review Article

Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Epigenetic reprogramming may underlie adverse health outcomes linked to in utero and early life iAs exposure.

Graphical abstract: Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data
From the themed collection: Recent Review Articles
Review Article

Biological effects, translocation, and metabolism of quantum dots in the nematode Caenorhabditis elegans

We summarize recent progress on the biological effects, translocation, and metabolism of QDs in the in vivo assay system of C. elegans.

Graphical abstract: Biological effects, translocation, and metabolism of quantum dots in the nematode Caenorhabditis elegans
From the themed collection: Recent Review Articles
Review Article

Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)

Recent updates on various molecular and pathophysiological aspects of the zinc transporter ZIP8 (SLC39A8).

Graphical abstract: Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)
From the themed collection: Recent Review Articles
Review Article

The effects of T-2 toxin on the prevalence and development of Kashin–Beck disease in China: a meta-analysis and systematic review

The interpretation of high T-2 toxin detection rate and amount in endemic areas on Kashin–Beck disease prevalence and development.

Graphical abstract: The effects of T-2 toxin on the prevalence and development of Kashin–Beck disease in China: a meta-analysis and systematic review
From the themed collection: Recent Review Articles
Review Article

Mycotoxins: cytotoxicity and biotransformation in animal cells

Mycotoxins can be biotransformed by phase I and phase II enzymes in animals. However, most of the mycotoxin at high dosage combined with their metabolites can cause carcinogenesis and various cytotoxicity, such as apoptosis, lipids oxidation and cell cycle arrest, etc., and most of which are related to oxidative stress.

Graphical abstract: Mycotoxins: cytotoxicity and biotransformation in animal cells
From the themed collection: Recent Review Articles
Review Article

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review

Organisms respond to exogenous threats and insults by a potent inflammatory and immune response, aimed at preserving tissue integrity and restoring tissue homeostasis and function.

Graphical abstract: Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
From the themed collection: Recent Review Articles
Review Article

Computational toxicology, friend or foe?

Computational approaches offer the attraction of being both fast and cheap to run being able to process thousands of chemical structures in a few minutes. As with all new technology, there is a tendency for these approaches to be hyped up and claims of reliability and performance may be exaggerated. So just how good are these computational methods?

Graphical abstract: Computational toxicology, friend or foe?
From the themed collection: Recent Review Articles
Review Article

Complicity of haem in some adverse drug-reactions

Genetic variants in haem metabolism enzymes can be predisposition factors for adverse reactions in some individuals. New areas of haem biology may also be associated with idiosyncratic effects which are yet to be identified.

Graphical abstract: Complicity of haem in some adverse drug-reactions
From the themed collection: Recent Review Articles
Review Article

Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs

The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.

Graphical abstract: Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs
From the themed collection: Recent Review Articles
Review Article

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid

Aristolochic acids (AA) are human renal carcinogens found in all Aristolochia herbaceous plants, many of which have been used worldwide for medicinal purposes for centuries.

Graphical abstract: New approaches for biomonitoring exposure to the human carcinogen aristolochic acid
From the themed collection: Recent Review Articles
Review Article

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

T-cells are activated by different mechanisms in the presence of drugs, metabolites or haptens, and they release several molecules that can be used in the diagnosis of drug hypersensitivity.

Graphical abstract: Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity
From the themed collection: Recent Review Articles
Review Article

The puzzle of toxicity of gold nanoparticles. The case-study of HeLa cells

Data on the viability of HeLa cells exposed to functionalized gold nanoparticles have been analyzed on the basis of metrics based on the numerical particle concentration that takes into account both the size and shape of the nanoparticles.

Graphical abstract: The puzzle of toxicity of gold nanoparticles. The case-study of HeLa cells
From the themed collection: Recent Review Articles
Review Article

In vitro models for neurotoxicology research

The nervous system has a highly complex organization, including many cell types with multiple functions, with an intricate anatomy and unique structural and functional characteristics; the study of its (dys)functionality following exposure to xenobiotics, neurotoxicology, constitutes an important issue in neurosciences.

Graphical abstract: In vitro models for neurotoxicology research
From the themed collection: Recent Review Articles
Review Article

Autophagy as the effector and player in DNA damage response of cells to genotoxicants

In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.

Graphical abstract: Autophagy as the effector and player in DNA damage response of cells to genotoxicants
From the themed collection: Recent Review Articles
Review Article

Beyond a means of exposure: a new view of the mother in toxicology research

Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.

Graphical abstract: Beyond a means of exposure: a new view of the mother in toxicology research
From the themed collection: Recent Review Articles
Review Article

Metal toxicity and the p53 protein: an intimate relationship

The relationship between p53, ROS and transition metals.

Graphical abstract: Metal toxicity and the p53 protein: an intimate relationship
From the themed collection: Recent Review Articles
Review Article

Silver nanoparticles – wolves in sheep's clothing?

We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.

Graphical abstract: Silver nanoparticles – wolves in sheep's clothing?
From the themed collection: Recent Review Articles
Review Article

The Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.

Graphical abstract: The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
From the themed collection: Recent Review Articles
Review Article

An expandable donor-free supply of functional hepatocytes for toxicology

The B-13 cell is a readily expandable rat pancreatic acinar-like cell that differentiates on simple plastic culture substrata into replicatively-senescent hepatocyte-like (B-13/H) cells in response to glucocorticoid exposure.

Graphical abstract: An expandable donor-free supply of functional hepatocytes for toxicology
From the themed collection: Recent Review Articles
Review Article

Manganese-induced neurotoxicity: from C. elegans to humans

Manganese (Mn) is neurotoxic, and its effect is mediated by net transport across cell membranes. (WT: the intact dopaminergic (DAergic) neurons in the head of C. elegans, in the absence of Mn exposure; + Mn: the DAergic neurons undergo neurodegeneration upon Mn exposure.)

Graphical abstract: Manganese-induced neurotoxicity: from C. elegans to humans
From the themed collection: Recent Review Articles
31 items

About this collection

Toxicology Research publishes authoritative and insightful review articles covering all aspects of the journal scope. In this collection, we have brought together recent reviews published in the journal– we hope you enjoy reading them.

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