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Themed collection Top 50 Articles of 2016: Organic Chemistry

12 articles
Open Access Perspective

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.

Graphical abstract: Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Perspective

Pot economy and one-pot synthesis

This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.

Graphical abstract: Pot economy and one-pot synthesis
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Minireview

Peptide-based synthetic vaccines

This review summarise the current stand and future perspective on synthetic peptide-based vaccines.

Graphical abstract: Peptide-based synthetic vaccines
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

A metal-free C–B bond forming reaction of aryl halides under batch and continuous-flow conditions is described.

Graphical abstract: Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported.

Graphical abstract: The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds

A highly tunable visible-light-promoted reaction system for the radical-mediated functionalization of tertiary aliphatic C–H bonds of complex substrates has been developed.

Graphical abstract: A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

Aminofluorination: transition-metal-free N–F bond insertion into diazocarbonyl compounds

Gem-aminofluorination of diazocarbonyl compounds has been achieved for the first time.

Graphical abstract: Aminofluorination: transition-metal-free N–F bond insertion into diazocarbonyl compounds
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

Rh(III)-catalyzed diastereoselective C–H bond addition/cyclization cascade of enone tethered aldehydes

Rh(III)-catalyzed cascade addition of C–H bonds across alkene and carbonyl π-bonds to form two new σ C–C bonds is accomplished.

Graphical abstract: Rh(iii)-catalyzed diastereoselective C–H bond addition/cyclization cascade of enone tethered aldehydes
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

Visible light-mediated gold-catalysed carbon(sp2)–carbon(sp) cross-coupling

A new method for the alkynylation of aryldiazonium salts with TMS-alkynes via dual gold and photoredox catalysis is described.

Graphical abstract: Visible light-mediated gold-catalysed carbon(sp2)–carbon(sp) cross-coupling
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Dual gold/photoredox-catalyzed C(sp)–H arylation of terminal alkynes with diazonium salts

The arylation of alkyl and aromatic terminal alkynes by a dual gold/photoredox catalytic system is described.

Graphical abstract: Dual gold/photoredox-catalyzed C(sp)–H arylation of terminal alkynes with diazonium salts
From the themed collection: Top 50 Articles of 2016: Energy and Catalysis
Open Access Edge Article

Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines

One-pot trifluoromethoxylation of functionalized pyridines and pyrimidines via OCF3-migraion.

Graphical abstract: Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.

Graphical abstract: Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
From the themed collection: Global challenges: Health & Food
12 articles

About this collection

We are delighted to present a collection showcasing the 50 most downloaded Chemical Science articles of 2016. This is only available for a limited time and provides an easy way to quickly access the most important papers published in Chemical Science in the past year. These articles highlight exciting and impactful research across a broad range of subject areas, analytical chemistry, chemical biology, catalysis, energy, inorganic chemistry, materials science, nanoscience, organic chemistry and physical chemistry. We hope you enjoy reading this collection!

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