Themed collection In celebration of Chinese New Year

Covalent and non-covalent approaches to tune the stability of organic radicals through steric effects and the delocalization of spin density.

Activatable molecualr agents that intergrate diagnosis and treatment modalities have attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome.

The dynamic fluctuations of bioactive species in living cells are associated with numerous physiological and pathological phenomena. The emergence of organelle-targeted fluorescent probes has significantly facilitated our understanding on the biological functions of these species. This review describes the design, applications, challenges and potential directions of organelle-targeted bioactive species probes.

Cascade reactions that produce multiple chemical bonds in one synthetic operation are important in the efficient construction of complex molecules.

This review summarizes recent advances in the design and synthesis of stable MOFs and highlights the relationships between the stability and functional applications.

Zn–air batteries are under revival.

A novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines has been developed. The aliphatic C–H or C–C bond was selectively cleaved with the efficient formation of two C–N single bonds or a CN double bond.

Phosphindole oxide-based photosensitizers with Type I reactive oxygen species generation ability are developed and used for endoplasmic reticulum stress-mediated photodynamic therapy of tumors.

Here we report palladium-catalyzed, regiodivergent [5 + 4] and [5 + 2] annulations of vinylethylene carbonates and allylidenemalononitriles affording over 50 medium-sized heterocycles in high isolated yields with excellent regioselectivities.

Novel NIR-II organic fluorophores were designed and synthesized using an AIE and highly twisted donor–acceptor distortion strategy for bio-imaging beyond 1550 nm.

Target identification and drug repurposing could benefit from network-based, rational deep learning prediction, and explore the relationship between drugs and targets in the heterogeneous drug–gene–disease network.

Phase change material based H₂O₂ self-supply nanoparticles for enhanced thermal responsive chemodynamic tumor therapy.

Monolayer C₂N supported heteronuclear dual-atom catalysts are designed for efficient CO₂ electrochemical reduction.

Covalent organic frameworks (COFs) show great promise as heterogeneous photocatalysts, but they have not yet been explored for asymmetric photocatalysis, which is important for the sustainable production of pharmaceuticals and fine chemicals.

Formyl-selective deuteration of aldehydes with D₂O mediated by the synergistic combination of light-driven, polyoxometalate-facilitated HAT and thiol catalysis is reported.

The regioselective electrosynthesis of tetra- and hexa-functionalized [60]fullerene derivatives with unprecedented 1,2,4,17-(cis-3′) and 1,2,3,4,9,10-(“S”-shaped) addition patterns is achieved.

We report the bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C–C stereogenic axes. These are controlled by a two-fold central-to-axial chirality conversion upon oxidative aromatization.

Pd-catalyzed ligand-enabled γ-C(sp³)–H arylation of tert-leucine and its derived peptides without using an external directing group via a less favored six-membered palladacycle is reported.

Nitric oxide-releasing amphiphiles are successfully synthesized through direct polymerization and are engineered as photoresponsive polymersomes for biomedical applications.

A systematic structure–property correlation study was conducted to preliminarily elucidate an inherent regularity governing the structure of dopant-free HTMs.

By regulating the composition of solvents, the assembled nanostructures of chiral molecules transformed from 0D nanospheres to 3D nanoflakes, which showed significantly amplified circularly polarized luminescence.

The long-sought Y–Y bonding is experimentally observed in organometallic complexes for the first time by encapsulation inside the hollow cavity of C_3v(8)-C₈₂ and C_s(6)-C₈₂ fullerene cages.

Understanding how mesoporous noble metal architectures affect electrocatalytic performance is very important for the rational design and preparation of high-performance electrocatalysts.

Monofunctional platinum complexes restrain lung cancer through disrupting mitochondrial oxidative phosphorylation and glycolysis in addition to damaging nuclear and mitochondrial DNA.

Through-space charge transfer hexaarylbenzene dendrimers containing circularly-arrayed electron donors and acceptors exhibit thermally activated delayed fluorescence and aggregation-induced emission effects, giving EQE of 14.2% for solution-processed OLEDs.

A universal method to grow polymers on MOF surfaces with well-defined thickness, sequence and functionality.

Branched catalytic hairpin assembly is proposed for dynamic self-assembly of DNA dendrimers for signal amplification and in situ imaging of microRNAs in live cells with high sensitivity and selectivity.

Herein, we report a protocol for direct visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using molecular oxygen as an oxidant at room temperature.

Stimuli-responsive polyacrylamide hydrogels crosslinked by glucosamine–boronate/G-quadruplexes or azobenzene-functionalized DNA reveal controlled stiffness using chemical or photochemical triggers.

Synthesis of functionalized gem-difluoroalkenes was achieved through nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters.

By developing lithium-ion-active aerolysin, for the first time we have achieved aerolysin detection of single-stranded DNA longer than 100 nt.

A bioctahedral Ag₁₀ kernel is locked by a pair of Mo₇O₂₆¹⁰⁻ anions to form an inner Ag₁₀@(Mo₇O₂₆)₂ core which is further encapsulated by an outer Ag₇₀ shell to form three-shell Ag₁₀@(Mo₇O₂₆)₂@Ag₇₀ nanoclusters.

A probability-based computational screening study has successfully identified an optimal bimetallic alloy (Pt₃In) for the propane dehydrogenation reaction.