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Themed collection ISACS19: Challenges in Organic Chemistry

19 items
Open Access Edge Article

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy

Stimulated Raman scattering (SRS) microscopy in tandem with bioorthogonal Raman labelling enables intracellular drug concentrations, distribution and therapeutic response to be measured in living cells.

Graphical abstract: Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Introducing unactivated acyclic internal aliphatic olefins into a cobalt catalyzed allylic selective dehydrogenative Heck reaction

A highly regio- and stereoselective cobalt catalyzed allylic selective dehydrogenative Heck reaction with internal aliphatic olefins was developed. Both internal and terminal aliphatic olefins can be employed, thereby significantly expanding the scope of alkenylation chemistry.

Graphical abstract: Introducing unactivated acyclic internal aliphatic olefins into a cobalt catalyzed allylic selective dehydrogenative Heck reaction
From the themed collection: ISACS19: Challenges in Organic Chemistry
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A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision

The core structure of the potent antimalarial alkaloid ocimicide A1 was prepared by a complex stereochemical relay. Computational studies suggest a structural revision of the metabolite is necessary.

Graphical abstract: A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision
From the themed collection: ISACS19: Challenges in Organic Chemistry
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The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes

A mild palladium-catalyzed ligand-controlled regioselective 1,3-arylfluorination of 2[H]-chromenes has been developed.

Graphical abstract: The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Versatile routes for synthesis of diarylamines through acceptorless dehydrogenative aromatization catalysis over supported gold–palladium bimetallic nanoparticles

In the presence of Au–Pd/TiO2, various kinds of symmetrically and unsymmetrically substituted diarylamines could effectively be synthesized starting from various combinations of substrates.

Graphical abstract: Versatile routes for synthesis of diarylamines through acceptorless dehydrogenative aromatization catalysis over supported gold–palladium bimetallic nanoparticles
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Identification of monodentate oxazoline as a ligand for copper-promoted ortho-C–H hydroxylation and amination

The use of a weakly coordinating monodentate directing group for copper-mediated ortho-hydroxylation and amination reactions allows for the identification of an external oxazoline ligand as a promoter.

Graphical abstract: Identification of monodentate oxazoline as a ligand for copper-promoted ortho-C–H hydroxylation and amination
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Selective synthesis of unsymmetric dibenzo[a,e]pentalenes by a rhodium-catalysed stitching reaction

A rhodium-catalysed stitching reaction between 2-(silylethynyl)arylboronates and 2-(silylethynyl)aryl bromides has been developed for the synthesis of unsymmetric dibenzo[a,e]pentalenes.

Graphical abstract: Selective synthesis of unsymmetric dibenzo[a,e]pentalenes by a rhodium-catalysed stitching reaction
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Enantioselective bifunctional iminophosphorane catalyzed sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters

The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters catalyzed by a bifunctional iminophosphorane (BIMP) organocatalyst is described.

Graphical abstract: Enantioselective bifunctional iminophosphorane catalyzed sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

A multidisciplinary approach, composed of organic synthesis, electrochemistry, electrocatalysis and cellular studies, for correlating the molecular features of a 1,2-naphthoquinone scaffold with its ROS generating ability.

Graphical abstract: Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Square channels formed by a peptide derived from transthyretin

X-ray crystallography reveals that a macrocyclic peptide derived from transthyretin (TTR) assembles to form square channels.

Graphical abstract: Square channels formed by a peptide derived from transthyretin
From the themed collection: ISACS19: Challenges in Organic Chemistry
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The reactivity and conformational control of cyclic tetrapeptides derived from aziridine-containing amino acids

Regioselective ring-opening at a flexible N-acyl aziridine enables conformational control of α3β cyclic tetrapeptides through torsional strain.

Graphical abstract: The reactivity and conformational control of cyclic tetrapeptides derived from aziridine-containing amino acids
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones

A novel Pd-catalyzed intermolecular dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed.

Graphical abstract: Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones
From the themed collection: ISACS19: Challenges in Organic Chemistry
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Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding

Ir-catalyzed asymmetric allylic dearomatization affords five-membered aza-spiroindolenines, from which enantioenriched Pictet–Spengler-type products are obtained via a highly stereoselective migration.

Graphical abstract: Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Directing group assisted meta-hydroxylation by C–H activation

The first template assisted meta-hydroxylation strategy and its use in the synthesis of resveratrol precursor and QR-activity inducer with detailed experimental and in-silico mechanistic understanding.

Graphical abstract: Directing group assisted meta-hydroxylation by C–H activation
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid

Asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid catalyst, generates an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity.

Graphical abstract: Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Rational design of a quantitative, pH-insensitive, nucleic acid based fluorescent chloride reporter

This study describes the rational design of a DNA-based chloride reporter.

Graphical abstract: Rational design of a quantitative, pH-insensitive, nucleic acid based fluorescent chloride reporter
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Rhodium-catalyzed asymmetric synthesis of silicon-stereogenic silicon-bridged arylpyridinones

A rhodium-catalyzed regio- and enantioselective synthesis of silicon-stereogenic silicon-bridged arylpyridinones was developed. A reasonable catalytic cycle was also experimentally established.

Graphical abstract: Rhodium-catalyzed asymmetric synthesis of silicon-stereogenic silicon-bridged arylpyridinones
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: effective conversion of amines and anilines into amides

The rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes is reported.

Graphical abstract: Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: effective conversion of amines and anilines into amides
From the themed collection: ISACS19: Challenges in Organic Chemistry
Open Access Edge Article

Visible light-mediated gold-catalysed carbon(sp2)–carbon(sp) cross-coupling

A new method for the alkynylation of aryldiazonium salts with TMS-alkynes via dual gold and photoredox catalysis is described.

Graphical abstract: Visible light-mediated gold-catalysed carbon(sp2)–carbon(sp) cross-coupling
From the themed collection: ISACS19: Challenges in Organic Chemistry
19 items

About this collection

We are delighted to present this web collection which contains selected contributions from the ISACS19: Challenges in Organic Chemistry meeting held in Irvine, United States in March 2016. Delegates from countries around the world gathered to hear from leading researchers in this exciting field and now we have the opportunity to share with you exciting new research from a number of our plenary speakers and scientific committee members. We hope you enjoy the collection.

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