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Themed collection 2017 Organic Chemistry Frontiers Review-type Articles

13 items
Highlight

Diverse exploitation of Brønsted acid catalysts – paving the way for simple access to enantioenriched amines

Brønsted acid catalysis provided access to enantioenriched primary and secondary amines, paving the way to advancements in the area.

Graphical abstract: Diverse exploitation of Brønsted acid catalysts – paving the way for simple access to enantioenriched amines
Highlight

Chemoselective acyl C–O bond activation in esters for Suzuki–Miyaura coupling

The use of palladium–NHC (bulky) catalyst enables selective acylative coupling in esters via blocking the potential C(aryl)–O oxidative addition and decarbonylation processes. Mechanistic studies elucidate the role of bulky carbene catalysts in promoting C(acyl)–O activation, and as a result, the acyl metal intermediates undergo coupling without the loss of carbonyl group.

Graphical abstract: Chemoselective acyl C–O bond activation in esters for Suzuki–Miyaura coupling
Review Article

Catalytic C–H amination at its limits: challenges and solutions

Pushing C–H amination to its limits fosters innovative synthetic solutions and offers a deeper understanding of the reaction mechanism and scope.

Graphical abstract: Catalytic C–H amination at its limits: challenges and solutions
Review Article

Metal-mediated C–O bond forming reactions in natural product synthesis

Metal catalyzed reactions for the formation of C(sp2)–O bonds have had a dramatic impact in natural product synthesis. They have enabled the emergence of new bond disconnections, which notably resulted in remarkably efficient and short synthetic pathways. The use of these reactions for the formation of C–O bonds in natural product synthesis is overviewed in this critical review.

Graphical abstract: Metal-mediated C–O bond forming reactions in natural product synthesis
Review Article

Metal-catalyzed enyne cycloisomerization in natural product total synthesis

Enyne cycloisomerization has become a powerful and attractive strategy for the construction of cyclic compounds, thus possessing great potential for applications in total synthesis of natural products and pharmaceuticals.

Graphical abstract: Metal-catalyzed enyne cycloisomerization in natural product total synthesis
Review Article

Catalytic and catalyst-free diboration of alkynes

The present review provides a comprehensive summary of the catalytic and catalyst-free diboration of alkynes.

Graphical abstract: Catalytic and catalyst-free diboration of alkynes
Review Article

Catalytic asymmetric synthesis of hetero-substituted oxindoles

The construction of chiral disubstituted oxindoles is an intriguing challenge for organic chemists.

Graphical abstract: Catalytic asymmetric synthesis of hetero-substituted oxindoles
Review Article

Lu's [3 + 2] cycloaddition of allenes with electrophiles: discovery, development and synthetic application

The discovery of Lu's [3 + 2] cycloaddition reaction is briefly introduced, and the recent important developments and synthetic applications of Lu's [3 + 2] cycloaddition reaction are highlighted and overviewed.

Graphical abstract: Lu's [3 + 2] cycloaddition of allenes with electrophiles: discovery, development and synthetic application
Review Article

Stereoselective strategies for the construction of polysubstituted piperidinic compounds and their applications in natural products’ synthesis

An abridged and far-reaching review communication on the construction of the polysubstituted piperidinic core using diverse methodologies for the benefit of organic chemists interested in the total synthesis of biologically active compounds.

Graphical abstract: Stereoselective strategies for the construction of polysubstituted piperidinic compounds and their applications in natural products’ synthesis
Review Article

Recent advances in positional-selective alkenylations: removable guidance for twofold C–H activation

Recent advances in transition-metal catalyzed positional-selective alkenylations via twofold C–H activation directed by removable or traceless directing groups are reviewed.

Graphical abstract: Recent advances in positional-selective alkenylations: removable guidance for twofold C–H activation
Review Article

Cyclopropenes: a new tool for the study of biological systems

Cyclopropenes have become an important mini-tag tool in chemical biology, participating in fast inverse electron demand Diels–Alder and photoclick reactions in biological settings.

Graphical abstract: Cyclopropenes: a new tool for the study of biological systems
Review Article

Nanocalipers as novel molecular scaffolds for carbon nanotubes

Nanocalipers were synthesized by connecting directly the five aromatic moieties including two receptors, two corners and a core, and found to discriminate the diameter, metallicity and handedness of carbon nanotubes through selective complexation.

Graphical abstract: Nanocalipers as novel molecular scaffolds for carbon nanotubes
Review Article

Methodology and applications of the hexadehydro-Diels–Alder (HDDA) reaction

Hexadehydro-Diels–Alder (HDDA) reactions between alkynes and 1,3-diynes readily generate highly reactive and synthetically useful arynes.

Graphical abstract: Methodology and applications of the hexadehydro-Diels–Alder (HDDA) reaction
13 items

About this collection

Critical reviews and highlight articles published in Organic Chemistry Frontiers during 2017 are collated as below for the benefit of readers.

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