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Themed collection Synthetic methodology in OBC

265 items - Showing page 1 of 4
Review Article

Recent developments in functionalization of acyclic α-keto amides

This review describes the synthetic utility of α-keto amides to synthesize various important molecules via mono, dual and triple functionalization reactions.

Graphical abstract: Recent developments in functionalization of acyclic α-keto amides
From the themed collection: Synthetic methodology in OBC
Review Article

C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

Recent synthetic applications and methodological advancements of the Pd(II)-catalyzed C2 functionalisation of indoles are highlighted and discussed in this review.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the annulation of Morita–Baylis–Hillman adducts

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita–Baylis–Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups.

Graphical abstract: Recent advances in the annulation of Morita–Baylis–Hillman adducts
From the themed collection: Synthetic methodology in OBC
Review Article

Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant

This review is focused on recent developments in the use of small organic molecules as photocatalysts.

Graphical abstract: Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant
From the themed collection: Synthetic methodology in OBC
Review Article

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

This review describes recent developments in the use of catalytic transient directing groups, through imine linkages, which in combination with transition metal catalysts provide streamlined C–H functionalisation processes.

Graphical abstract: Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation
Review Article

Copper nitrate: a privileged reagent for organic synthesis

This review demonstrates the state-of-the-art applications of copper nitrate as a nitration reagent, oxidant, catalyst, promoter and precursor of nitrile oxides.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of polyheterocycles via multicomponent reactions

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields.

Graphical abstract: Synthesis of polyheterocycles via multicomponent reactions
From the themed collection: Synthetic methodology in OBC
Review Article

C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process

This review is focused on the recent advances in the C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process. Diverse substituted hydrazones including N-heterocycles are afforded under mild conditions with excellent selectivities. In general, an aminyl radical as the key intermediate is involved during the reaction process.

Graphical abstract: C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process
From the themed collection: Synthetic methodology in OBC
Review Article

Nitrilium ions – synthesis and applications

Access to both stable and transient nitrilium ions and the use of these synthons in the organic synthesis of imines and a large spectrum of heterocycles and transition metal complexes are succinctly summarized.

Graphical abstract: Nitrilium ions – synthesis and applications
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Copper(I)-Catalysed Stereoselective Debromoborylation of Aliphatic 1,1-Dibromo-1-Alkenes with Bis(pinacolato)diboron

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Silver-catalyzed intermolecular amination of fluoroarenes

From the themed collection: Synthetic methodology in OBC
Communication

Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts

In this communication, an interesting phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts has been reported.

Graphical abstract: Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines

The di- and trichloromethylation of N-allyl anilines with CH2Cl2, CHCl3 and CCl4 was developed, leading to di- and trichloromethylated indolines.

Graphical abstract: Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines
From the themed collection: Synthetic methodology in OBC
Communication

E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes

An efficient and highly E-selective protocol for the synthesis of vinyl sulfones is described.

Graphical abstract: E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes
From the themed collection: Synthetic methodology in OBC
Communication

2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes

2-Picoline efficiently catalyzes the formation of α,β-enones from acetylenedicarboxylates and aldehydes in the presence of alkenes, thereby leading to pyrans with complete regioselectivities. This method is represented as a first example of catalytic and metal-free [2 + 2 + 2] cycloaddition of three different components.

Graphical abstract: 2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides.

Graphical abstract: Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

An efficient procedure for imidazo[1,5-a]pyridine formation via dual oxidative Csp3–H amination using elemental sulfur is described.

Graphical abstract: Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination
From the themed collection: Synthetic methodology in OBC
Communication

Two catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as oxidants

The development of two new catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as terminal oxidants.

Graphical abstract: Two catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as oxidants
From the themed collection: Synthetic methodology in OBC
Communication

Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

A transition-metal-free, operationally simple and atom-economic protocol that converts isocyanoacetates and aurones to 2,3,4-trisubstituted pyrroles catalyzed by NaOH was presented.

Graphical abstract: Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues
From the themed collection: Synthetic methodology in OBC
Communication

The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(III) reagents

Aradical acylarylation of N-arylacrylamides with aliphatic aldehydes using a combination of hypervalent iodine(III) reagents and UV light is reported.

Graphical abstract: The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(iii) reagents
From the themed collection: Synthetic methodology in OBC
Communication

Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles

A new and efficient Pd-catalyzed cascade cyclization of biaryl-tethered o-alkynylanilines for the formation of dibenzo[a,c]carbazole derivatives has been reported.

Graphical abstract: Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles
From the themed collection: Synthetic methodology in OBC
Communication

TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent.

Graphical abstract: TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one
From the themed collection: Synthetic methodology in OBC
Communication

Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO3)3·9H2O

Al(NO3)3·9H2O as a nitro source for the synthesis of 3-nitrofurans from homopropargylic alcohols through Fe-catalyzed tandem cyclization is described.

Graphical abstract: Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO3)3·9H2O
From the themed collection: Synthetic methodology in OBC
Communication

Phosphine-catalysed α-umpolung addition of nucleophiles to δ-acetoxy allenoates: stereoselective synthesis of 2,4-dienoates

The first example of phosphine-catalyzed α-umpolung addition of nucleophiles to allenoates is described, which features the use of δ-acetoxy allenoate to generate a 3-phosphonium-2,4-dienoate intermediate, thus facilitating the α-umpolung addition of nucleophiles.

Graphical abstract: Phosphine-catalysed α-umpolung addition of nucleophiles to δ-acetoxy allenoates: stereoselective synthesis of 2,4-dienoates
From the themed collection: Synthetic methodology in OBC
Communication

Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

Graphical abstract: Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles
From the themed collection: Synthetic methodology in OBC
Communication

Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature

A wide range of glycals underwent C-arylation with aryldiazonium tetrafluoroborates and provided synthetically useful 2,3-deoxy 3-keto α-aryl-C-glycosides in good to excellent yields.

Graphical abstract: Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature
From the themed collection: Synthetic methodology in OBC
Communication

Carbenium ion formation by fragmentation of electrochemically generated oxonium ions

Fragmentation of electrochemically generated oxonium ions can be exploited to form carbenium ions at a low oxidation potential in the presence of a nucleophile such as allylsilane.

Graphical abstract: Carbenium ion formation by fragmentation of electrochemically generated oxonium ions
From the themed collection: Synthetic methodology in OBC
Communication

Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides

A t-BuONa-mediated C–OH/P(O)–H cross dehydration coupling is developed to construct sp3 C–P bonds.

Graphical abstract: Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides
From the themed collection: Synthetic methodology in OBC
Communication

An efficient t-BuOK promoted C3-chalcogenylation of indoles with dichalcogenides

A practical route to prepare 3-sulfenyl- and 3-selenyl-indoles has been achieved using t-BuOK as a promoter at room temperature.

Graphical abstract: An efficient t-BuOK promoted C3-chalcogenylation of indoles with dichalcogenides
From the themed collection: Synthetic methodology in OBC
Communication

(2-Fluoroallyl)boronates: new reagents for diastereoselective 2-fluoroallylboration of aldehydes

New reagents for anti-selective 2-fluoroallylboration of aromatic and aliphatic aldehydes—(2-fluoroallyl)pinacolboranes, were prepared by Pd-catalyzed borylation of 2-fluoroallyl chlorides.

Graphical abstract: (2-Fluoroallyl)boronates: new reagents for diastereoselective 2-fluoroallylboration of aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Second-order asymmetric transformation and its application for the practical synthesis of α-amino acids

Design of a rimantadine [1-(1-adamantyl)ethanamine]-derived chiral ligand and its application for the preparation of α-amino acids via second-order asymmetric transformation is reported.

Graphical abstract: Second-order asymmetric transformation and its application for the practical synthesis of α-amino acids
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free C(sp3)–H bond sulfonyloxylation of 2-alkylpyridines and alkylnitrones

Direct transformation of an inert C(sp3)–H bond of 2-alkylpyridines and nitrones into a C–OSO2R bond has been described.

Graphical abstract: Metal-free C(sp3)–H bond sulfonyloxylation of 2-alkylpyridines and alkylnitrones
From the themed collection: Synthetic methodology in OBC
Communication

Base-mediated 1,6-conjugate addition of the Seyferth–Gilbert reagent to para-quinone methides

An efficient 1,6-conjugate addition reaction of the Seyferth–Gilbert reagent (SGR) to p-quinone methides leading to the synthesis of diarylmethylated diazomethylphosphonates is reported.

Graphical abstract: Base-mediated 1,6-conjugate addition of the Seyferth–Gilbert reagent to para-quinone methides
From the themed collection: Synthetic methodology in OBC
Communication

The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

A novel [3 + 2] cycloaddition reaction of azaoxyallyl cations and aromatic ethylenes has been developed to afford multi-substituted pyrrolidinones in moderate to good yields.

Graphical abstract: The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes
From the themed collection: Synthetic methodology in OBC
Communication

Chiral NHC-catalyzed 1,3-dipolar [3 + 2] cycloaddition of azomethine imines with α-chloroaldehydes for the synthesis of bicyclic pyrazolidinones

An NHC-catalyzed [3 + 2] cycloaddition reaction of azomethine imines and α-chloroaldehydes was developed for the synthesis of chiral bicyclic pyrazolidinone derivatives.

Graphical abstract: Chiral NHC-catalyzed 1,3-dipolar [3 + 2] cycloaddition of azomethine imines with α-chloroaldehydes for the synthesis of bicyclic pyrazolidinones
From the themed collection: Synthetic methodology in OBC
Communication

Formal [4 + 2] cycloaddition of imines with alkoxyisocoumarins

A new preparation of δ-lactams is reported.

Graphical abstract: Formal [4 + 2] cycloaddition of imines with alkoxyisocoumarins
From the themed collection: Synthetic methodology in OBC
Communication

Base-controlled Fe(Pc)-catalyzed aerobic oxidation of thiols for the synthesis of S–S and S–P(O) bonds

Base-controlled Fe(Pc)-catalyzed S–S/S–P(O) bond formation.

Graphical abstract: Base-controlled Fe(Pc)-catalyzed aerobic oxidation of thiols for the synthesis of S–S and S–P(O) bonds
From the themed collection: Synthetic methodology in OBC
Communication

Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

An elemental sulfur-based metal- and base-free system enables oxidative imidazo[1,2-a]pyridine annulations.

Graphical abstract: Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives

A copper-catalyzed domino protocol for the synthesis of 2-(1,3,5-triazin-2-yl)anilines has been developed from isatins and amidine hydrochlorides at ambient temperature.

Graphical abstract: Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source

A practical route to dithioacetals has been achieved via methylene insertion into disulfide bonds using acetone as a methylene source.

Graphical abstract: Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source
From the themed collection: Synthetic methodology in OBC
Communication

Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature

A protocol for the chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder under an oxygen atmosphere is reported.

Graphical abstract: Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature
From the themed collection: Synthetic methodology in OBC
Communication

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

A novel and efficient ortho-nitration reaction of aniline derivatives using the inexpensive and nontoxic Fe(NO3)3·9H2O as a promoter and a nitro source has been developed.

Graphical abstract: Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed.

Graphical abstract: Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds
From the themed collection: Synthetic methodology in OBC
Communication

Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls

This reaction provides the first example of using a functionalized isocyanide in double insertion to construct nitrogen-containing heterocyclic systems.

Graphical abstract: Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls
From the themed collection: Synthetic methodology in OBC
Communication

Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

A novel protocol towards the rapid assembly of C5-alkylated indole derivatives has been developed via gold-catalyzed regioselective functionalization and subsequent oxidative aromatization.

Graphical abstract: Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles
From the themed collection: Synthetic methodology in OBC
Communication

Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitor

A copper catalysed regiospecific de-aryloxylative amination of O- or N-chelating group-functionalized 2-aryloxyquinolines constitutes a new route to access a PRMT5 inhibitor.

Graphical abstract: Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitor
From the themed collection: Synthetic methodology in OBC
Communication

Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid.

Graphical abstract: Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid
From the themed collection: Synthetic methodology in OBC
Communication

Iridium-catalyzed C–H phosphoramidation of N-aryl-7-azaindoles with phosphoryl azides

An iridium-catalyzed C–H phosphoramidation of N-aryl-7-azaindoles with phosphoryl azides was developed, affording a series of 7-azaindole phenylphosphoramidates.

Graphical abstract: Iridium-catalyzed C–H phosphoramidation of N-aryl-7-azaindoles with phosphoryl azides
From the themed collection: Synthetic methodology in OBC
Communication

Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles

An iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines has been developed. This reaction enables the convenient synthesis of a variety of 5-(3-indolyl)oxazoles under mild conditions with broad functional group compatibility.

Graphical abstract: Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles
From the themed collection: Synthetic methodology in OBC
Communication

Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy

A metal-free and efficient synthesis of highly substituted diaryl sulfones via a base-mediated [3 + 3] benzannulation strategy.

Graphical abstract: Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy
From the themed collection: Synthetic methodology in OBC
Communication

Neighboring phenolic group-activated gem-difluoroallylboration of imines for the catalyst-free synthesis of gem-difluorohomoallylamines

An unprecedented imine allylation with pinacol gem-difluoroallylborates for the synthesis of a wide range of racemic gem-difluorohomoallylamine derivatives under catalyst-free conditions was enabled by a neighboring phenolic group in an N-protecting group.

Graphical abstract: Neighboring phenolic group-activated gem-difluoroallylboration of imines for the catalyst-free synthesis of gem-difluorohomoallylamines
From the themed collection: Synthetic methodology in OBC
Communication

Catalyst-free [3 + 2] cyclization of dihydroisoquinoline imines and isatin-derived Morita–Baylis–Hillman carbonates via 1,5-electrocyclization: synthesis of tetrahydroisoquinoline-fused spirooxindoles

The incorporation of tetrahydroisoquinoline and spirooxindole frameworks has been achieved.

Graphical abstract: Catalyst-free [3 + 2] cyclization of dihydroisoquinoline imines and isatin-derived Morita–Baylis–Hillman carbonates via 1,5-electrocyclization: synthesis of tetrahydroisoquinoline-fused spirooxindoles
From the themed collection: Synthetic methodology in OBC
Communication

An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons

A series of trifluoromethyl dihydroquinazolinones were obtained in excellent results via an asymmetric Mannich reaction of pyrazoleamides and cyclic trifluoromethyl ketimines.

Graphical abstract: An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons
From the themed collection: Synthetic methodology in OBC
Communication

NFSI-participated intermolecular aminoazidation of alkene through iron catalysis

An iron-catalysed intermolecular vicinal aminoazidation of alkene with NFSI is reported, with broader alkene scope comparing to previously reported aminoazidation.

Graphical abstract: NFSI-participated intermolecular aminoazidation of alkene through iron catalysis
From the themed collection: Synthetic methodology in OBC
Communication

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C–N bond cleavage.

Graphical abstract: Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free iodine(III)-promoted synthesis of 2,5-diaryloxazoles

An efficient nonmetal-catalyzed reaction for 2,5-disubstituted oxazoles from chalcone under mild conditions with highly atom-economical transformation.

Graphical abstract: Metal-free iodine(iii)-promoted synthesis of 2,5-diaryloxazoles
From the themed collection: Synthetic methodology in OBC
Communication

Gold(I)- and rhodium(III)-catalyzed formal regiodivergent C–H alkynylation of 1-arylpyrazolones

A transition-metal-catalyzed formal regiodivergent C–H alkynylation of 1-aryl-5-pyrazolones is described.

Graphical abstract: Gold(i)- and rhodium(iii)-catalyzed formal regiodivergent C–H alkynylation of 1-arylpyrazolones
From the themed collection: Synthetic methodology in OBC
Communication

Cyrene as a bio-based solvent for HATU mediated amide coupling

Cyrene was found to be an effective bio-based solvent for HATU mediated amide bond formation.

Graphical abstract: Cyrene as a bio-based solvent for HATU mediated amide coupling
From the themed collection: Synthetic methodology in OBC
Communication

Copper-mediated regioselective hydrodifluoroalkylation of alkynes

A highly regioselective copper-mediated hydrodifluoroalkylation of alkynes with ethyl bromodifluoroacetate or bromodifluoroacetamides has been developed.

Graphical abstract: Copper-mediated regioselective hydrodifluoroalkylation of alkynes
From the themed collection: Synthetic methodology in OBC
Communication

Ruthenium(II)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

Remote C–H addition of 8-aminoquinoline amides at C-5 position to activated aldehydes have been developed using Ru(II)-catalyst.

Graphical abstract: Ruthenium(ii)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde
From the themed collection: Synthetic methodology in OBC
Communication

An I2-mediated aerobic oxidative annulation of amidines with tertiary amines via C–H amination/C–N cleavage for the synthesis of 2,4-disubstituted 1,3,5-triazines

An iodine-mediated aerobic oxidative cycloaddition of amidines with tertiary amines was first demonstrated, affording symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines.

Graphical abstract: An I2-mediated aerobic oxidative annulation of amidines with tertiary amines via C–H amination/C–N cleavage for the synthesis of 2,4-disubstituted 1,3,5-triazines
From the themed collection: Synthetic methodology in OBC
Communication

Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives

Annulation reaction of vinylsulfonium salts with β-naphthols and 4-hydroxycoumarins provided dihydrofuran derivatives in moderate to good yields under mild conditions.

Graphical abstract: Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Gold(I)-catalyzed diastereoselective synthesis of 1-α-oxybenzyl-1H-indenes

The gold(I)-catalyzed oxycyclization of β-aryl monosubstituted o-(alkynyl)styrenes gives rise to 1-α-methoxy or 1-α-hydroxybenzyl-1H-indenes in a diastereospecific way.

Graphical abstract: Gold(i)-catalyzed diastereoselective synthesis of 1-α-oxybenzyl-1H-indenes
From the themed collection: Synthetic methodology in OBC
Communication

Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration

An effective dehydrochlorination of bis(phenylsulfonyl)alkane to prepare alkene building blocks is developed.

Graphical abstract: Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration
From the themed collection: Synthetic methodology in OBC
Communication

Pd-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides

Indoline-2-carboxylate-containing dipeptides were synthesized from dipeptides via Pd-catalyzed intramolecular C–H amination.

Graphical abstract: Pd-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides
From the themed collection: Synthetic methodology in OBC
Communication

Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles

A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C–F bond cleavage was developed.

Graphical abstract: Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles
From the themed collection: Synthetic methodology in OBC
Communication

PhI(OAc)2-mediated dearomative C–N coupling: facile construction of the spiro[indoline-3,2′-pyrrolidine] skeleton

A facile construction of the spiro[indole-3,2′-pyrrolidine] skeleton, through diacetoxyiodobenzene (PIDA) mediated C–N bond-forming dearomatization of C3 sulfonamide linked indole derivatives, has been developed.

Graphical abstract: PhI(OAc)2-mediated dearomative C–N coupling: facile construction of the spiro[indoline-3,2′-pyrrolidine] skeleton
From the themed collection: Synthetic methodology in OBC
Communication

Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition

The metal-free C2-functionalization of chromones with alcohols and ethers via radical sp3 C–H activation was developed.

Graphical abstract: Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition
From the themed collection: Synthetic methodology in OBC
Communication

Access to 2-substituted-2H-indazoles via a copper-catalyzed regioselective cross-coupling reaction

A copper-catalyzed C–N cross-coupling reaction using commercially available 1H-indazoles with hypervalent iodine reagents to afford biologically active 2-substituted-2H-indazole is described.

Graphical abstract: Access to 2-substituted-2H-indazoles via a copper-catalyzed regioselective cross-coupling reaction
From the themed collection: Synthetic methodology in OBC
Communication

Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

A Cu/B2pin2 system promoted cyclization for the synthesis of 1-difluoroalkylated isoquinolines with vinyl isocyanides and bromodifluoroacetic derivatives in moderate to good yields was reported.

Graphical abstract: Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways
From the themed collection: Synthetic methodology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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