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Themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

112 items - Showing page 1 of 2
Perspective

Arylene ethynylene macrocycles: from molecular hosts to components of high-performance supramolecular architectures

This perspective highlights the recent utilization of arylene ethynylene macrocycles as supramolecular synthons—and speculates on what future may hold.

Graphical abstract: Arylene ethynylene macrocycles: from molecular hosts to components of high-performance supramolecular architectures
Perspective

Semi-synthesis of thioamide containing proteins

To make thioamide protein folding experiments applicable to full-sized proteins, our laboratory has used a combination of native chemical ligation of thiopeptide fragments, unnatural amino acid mutagenesis to install fluorophore partners in expressed protein fragments, and chemoenzymatic protein modification to render these expressed protein ligations traceless.

Graphical abstract: Semi-synthesis of thioamide containing proteins
Perspective

C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

The cellular protection mechanism, the heat shock response, is only activated by classical heat shock 90 inhibitors (Hsp90) that “target” the N-terminus of the protein, but not by those that modulate the C-terminus.

Graphical abstract: C-terminal heat shock protein 90 modulators produce desirable oncogenic properties
Open Access Perspective

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

The enolate cross coupling reaction is a highly efficient method for the de novo synthesis of aromatic rings.

Graphical abstract: Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles
Perspective

One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products

Multiple reactions in one pot has always been a useful technique for synthetic organic chemists, as it can minimizes solvent usage, time and the number of purification steps when compared to individual multi-step syntheses.

Graphical abstract: One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products
Open Access Perspective

Corrin-based chemosensors for the ASSURED detection of endogenous cyanide

Cassava (Manihot esculenta Crantz) is a staple food for more than 500 million people, especially in Africa and South America.

Graphical abstract: Corrin-based chemosensors for the ASSURED detection of endogenous cyanide
Perspective

Catalytic asymmetric desymmetrization approaches to enantioenriched cyclopentanes

Asymmetric desymmetrization represents an excellent strategy for obtaining highly functionalized chiral building blocks. However, the application of this strategy for the synthesis of cyclopentane derivatives remained limited, when compared to cyclohexanes. Here, we give an overview of asymmetric desymmetrization reactions leading to enantioenriched cyclopentanes.

Graphical abstract: Catalytic asymmetric desymmetrization approaches to enantioenriched cyclopentanes
Review Article

Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming

We review the methods of genetic code reprogramming and their use in discovering novel linear and cyclic polypeptides with non-proteinogenic chemistry.

Graphical abstract: Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming
Review Article

Strategy of total synthesis based on the use of Rh-catalyzed stereoselective 1,4-addition

In 1998, Hayashi and Miyaura reported the first asymmetric conjugate addition of aryl- and alkenyl-boronic acids to α,β-unsaturated ketones using chiral rhodium complexes as catalysts.

Graphical abstract: Strategy of total synthesis based on the use of Rh-catalyzed stereoselective 1,4-addition
Review Article

Disulfide-bridged peptide macrobicycles from nature

This review highlights known disulfide-bridged peptide bicycles and the studies on their unique structural and biological features.

Graphical abstract: Disulfide-bridged peptide macrobicycles from nature
Review Article

Benziporphyrins, a unique platform for exploring the aromatic characteristics of porphyrinoid systems

Benziporphyrins and related systems exhibit a wide range of properties and may possess nonaromatic, strongly aromatic or even antiaromatic characteristics.

Graphical abstract: Benziporphyrins, a unique platform for exploring the aromatic characteristics of porphyrinoid systems
Open Access Review Article

Anatomy of gold catalysts: facts and myths

This review article covers the main types of gold(I) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.

Graphical abstract: Anatomy of gold catalysts: facts and myths
Review Article

Gold and silver catalysis: from organic transformation to bioconjugation

A summary of gold (including AuNPs, Au(I) and Au(III) complexes) and silver(I) catalysis and their application in bioconjugation reactions.

Graphical abstract: Gold and silver catalysis: from organic transformation to bioconjugation
Open Access Review Article

Design and synthesis of analogues of natural products

In this article strategies for the design and synthesis of natural product analogues are summarized and illustrated with some selected examples.

Graphical abstract: Design and synthesis of analogues of natural products
Open Access Review Article

Supramolecular control of transition metal complexes in water by a hydrophobic cavity: a bio-inspired strategy

Different strategies for obtaining water-soluble cavity-appended metal complexes are described, and their resulting interlocked assets are discussed in relationship with the very specific properties of water as a solvent.

Graphical abstract: Supramolecular control of transition metal complexes in water by a hydrophobic cavity: a bio-inspired strategy
Review Article

Carbocycles from donor–acceptor cyclopropanes

Donor–acceptor cyclopropane annulations – not just for heterocycles.

Graphical abstract: Carbocycles from donor–acceptor cyclopropanes
Open Access Communication

Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill

Exploiting the rapid kinetics and low solvent requirements of mechanochemically-activated reactions, the instability of phosphorothiolate monoesters was bypassed enabling one-pot hydrolytic desilylation and phosphate coupling to be achieved in a ball mill.

Graphical abstract: Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill
Open Access Communication

Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection

Asymmetric trienamine catalysis was used to synthesize cytochalasin B-like compounds and inhibition of glucose uptake in cancer cells was demonstrated.

Graphical abstract: Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection
Communication

Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms

We report the discovery of potent biofilm-eradicating agents identified through a reductive amination reaction on the halogenated quinoline (HQ) scaffold.

Graphical abstract: Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms
Communication

The energetic viability of an unexpected skeletal rearrangement in cyclooctatin biosynthesis

Results of density functional theory calculations on possible mechanisms for formation of the diterpenoid cyclooctatin are described.

Graphical abstract: The energetic viability of an unexpected skeletal rearrangement in cyclooctatin biosynthesis
Communication

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

We report a concise approach to a multimodal imaging reagent for peptide labelling via disulfide bridging. The reagent is constructed using a one pot, three component, [3 + 2] cycloaddition of a fluorescent azide with a dithiomaleimide-alkyne, with concomitant incorporation of 125I.

Graphical abstract: A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging
Communication

Synthesis of a new class of iminosugars based on constrained azaspirocyclic scaffolds by way of catalytic C–H amination

High level of regiocontrol has been achieved in the C–H amination of substrates with a high density of reactive C–H bonds, allowing the access to a new class of conformationally constrained iminosugars.

Graphical abstract: Synthesis of a new class of iminosugars based on constrained azaspirocyclic scaffolds by way of catalytic C–H amination
Communication

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

Benzimidazoles were prepared in good yields via the iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines.

Graphical abstract: Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling
Communication

N–B dative bond-induced [3.3.0] bicyclic boronate-tethered exo-selective intramolecular Diels–Alder reaction

We report herein a highly exo-selective intramolecular Diels–Alder reaction of alkenyl boronates which employs an N–B dative bond-involved bicyclic rigid tether.

Graphical abstract: N–B dative bond-induced [3.3.0] bicyclic boronate-tethered exo-selective intramolecular Diels–Alder reaction
Communication

Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

NpFR2 is a fluorescent sensor that can reversibly measure changes in the mitochondrial redox environment.

Graphical abstract: Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells
Communication

Enantioselective N-heterocyclic carbene-catalyzed synthesis of indenopyrones

Chiral disubstituted indenopyrones were synthesized in high yields with exclusive cis-selectivity and excellent enantioselectivity via N-heterocyclic carbene catalysis.

Graphical abstract: Enantioselective N-heterocyclic carbene-catalyzed synthesis of indenopyrones
Communication

Biofunction-assisted aptasensors based on ligand-dependent 3′ processing of a suppressor tRNA in a wheat germ extract

We developed a novel type of biofunction-assisted aptasensor that utilizes ligand-dependent maturation of a suppressor tRNA probe and the subsequent expression of a reporter gene in a wheat germ extract.

Graphical abstract: Biofunction-assisted aptasensors based on ligand-dependent 3′ processing of a suppressor tRNA in a wheat germ extract
Communication

Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C–H bond activation followed by an intramolecular aza-Michael reaction is described.

Graphical abstract: Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs
Communication

Palladium-catalysed oxidative cross-esterification between two alcohols

Oxidative cross-esterification between two alcohols was achieved by using PdCl2(PPh3)2 as the sole catalyst and benzyl chloride as the oxidant.

Graphical abstract: Palladium-catalysed oxidative cross-esterification between two alcohols
Communication

Convenient synthesis of deazaflavin cofactor FO and its activity in F420-dependent NADP reductase

Revised synthesis of FO, a 5-deazaflavin cofactor, and its activity as a surrogate for the F420 cofactor in Fno.

Graphical abstract: Convenient synthesis of deazaflavin cofactor FO and its activity in F420-dependent NADP reductase
Communication

Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde

The rhodium(I)/chiral Ph-bpe-catalyzed reaction of vinylarenes with formaldehyde provides an accessible protocol for asymmetric hydroformylation to enantioenriched aldehydes in high yields.

Graphical abstract: Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde
Communication

DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a–N1′-linked pyrroloindoline alkaloids

The cross-coupling of tryptamine with substituted aniline to C3a–nitrogen-linked pyrroloindolines has been developed via the consecutive cyclization of tryptamine with DMSO/Tf2O and the substitution of 3a-pyrroloindolylthionium intermediate with aniline.

Graphical abstract: DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a–N1′-linked pyrroloindoline alkaloids
Communication

Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Crispene E inhibited STAT3 dimerization in a cell-free fluorescent polarization assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes.

Graphical abstract: Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells
Communication

Palladium-catalyzed direct arylation of phenols with aryl iodides

An efficient protocol of palladium-catalyzed direct para-arylation of unfunctionalized phenols with aryl iodides under mild conditions was reported.

Graphical abstract: Palladium-catalyzed direct arylation of phenols with aryl iodides
Open Access Communication

Regiodivergent Lewis base-promoted O- to C-carboxyl transfer of furanyl carbonates

Triazolinylidenes promote γ-selective C-carboxylation (up to 99 : 1 regioselectivity) in the O- to C-carboxyl transfer of furanyl carbonates in contrast to DMAP that promotes preferential α-C-carboxylation with moderate regiocontrol (typically 60 : 40 regioselectivity).

Graphical abstract: Regiodivergent Lewis base-promoted O- to C-carboxyl transfer of furanyl carbonates
Open Access Communication

Cyclopropanation using flow-generated diazo compounds

A practical and mild protocol for the cyclopropanation of unstabilised diazo compounds is reported.

Graphical abstract: Cyclopropanation using flow-generated diazo compounds
Communication

Oxidative asymmetric umpolung alkylation of Evans’ β-ketoimides using dialkylzinc nucleophiles

Umpolung alkylation of Evans’ auxiliary substituted β-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%.

Graphical abstract: Oxidative asymmetric umpolung alkylation of Evans’ β-ketoimides using dialkylzinc nucleophiles
Communication

Functional chromatographic technique for natural product isolation

Natural product discovery arises through a unique interplay between chromatographic purification and protein affinity.

Graphical abstract: Functional chromatographic technique for natural product isolation
Communication

Copper-catalyzed oxidative alkenylation of thioethers via Csp3–H functionalization

The first copper-catalyzed oxidative alkenylation of thioethers via Csp3–H functionalization to construct allylic thioethers is demonstrated.

Graphical abstract: Copper-catalyzed oxidative alkenylation of thioethers via Csp3–H functionalization
Communication

Bacterial patterning controlled by light exposure

Patterning of multiple bacterial strains in one system is achieved by employing a single photo-activated antibiotic.

Graphical abstract: Bacterial patterning controlled by light exposure
Communication

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

Graphical abstract: Divergolide congeners illuminate alternative reaction channels for ansamycin diversification
Communication

Highly selective and sensitive detection of glutathione using mesoporous silica nanoparticles capped with disulfide-containing oligo(ethylene glycol) chains

Mesoporous silica nanoparticles loaded with safranin O and capped with disulfide-containing oligo(ethylene glycol) chains were used for the selective and sensitive fluorimetric detection of GSH.

Graphical abstract: Highly selective and sensitive detection of glutathione using mesoporous silica nanoparticles capped with disulfide-containing oligo(ethylene glycol) chains
Open Access Communication

Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H

Stereoselectively labelled isotopomers of NAD(P)H are highly relevant for mechanistic studies of enzymes which utilize them as redox equivalents.

Graphical abstract: Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H
Open Access Communication

A peptide topological template for the dispersion of [60]fullerene in water

Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL−1 have been obtained using a peptide topological template as the carrier.

Graphical abstract: A peptide topological template for the dispersion of [60]fullerene in water
Communication

Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing π-extended diarylacetylene motifs

A novel series of C-modified π-extended 7-deazaadenosines exhibit promising fluorescence properties.

Graphical abstract: Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing π-extended diarylacetylene motifs
Communication

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms.

Graphical abstract: 6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA
Open Access Paper

Palladium-catalyzed enolate arylation as a key C–C bond-forming reaction for the synthesis of isoquinolines

The four-component, one-pot synthesis of isoquinolines utilizing the palladium-catalyzed α-arylation of ketone, ester and nitrile enolates.

Graphical abstract: Palladium-catalyzed enolate arylation as a key C–C bond-forming reaction for the synthesis of isoquinolines
Paper

The structure of tagetitoxin

The previously reported structure of tagetitoxin is incorrect. A new structure of tagetitoxin is proposed based on the NMR analysis.

Graphical abstract: The structure of tagetitoxin
Paper

Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers

Saturated isomers of the 1,2- 1,3- and 1,4-aminophenol pharmacophore have been prepared.

Graphical abstract: Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers
Paper

Cu(II)-catalyzed enantioselective oxygen atom transfer from oxaziridine to oxindole derivatives with chiral phenanthroline

In the presence of a Cu(II) complex of chiral, N,N,O-tridentate phenanthroline ligand (S)-2, asymmetric oxygen atom transfer of oxindole (3) using Davis’ oxaziridine (4) occurred to give the corresponding 3-aryl-3-hydroxy-2-oxindole derivatives (1) with excellent enantioselectivity.

Graphical abstract: Cu(ii)-catalyzed enantioselective oxygen atom transfer from oxaziridine to oxindole derivatives with chiral phenanthroline
Open Access Paper

B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether

The direct amidation of pharmaceutically relevant carboxylic acids and amines with B(OCH2CF3)3 in cyclopentyl methyl ether (CPME) is described.

Graphical abstract: B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether
Paper

Synthesis and stability of cyclic α-hydrogen nitroxides

Nitroxides (nitroxyl radicals) hold a unique place in science due to their stable radical nature.

Graphical abstract: Synthesis and stability of cyclic α-hydrogen nitroxides
Paper

Isolation and structural determination of non-racemic tertiary cathinone derivatives

In this paper the dynamic resolution of racemic tertiary cathinones is demonstrated through co-crystallization with enantiopure aromatic tartaric acids.

Graphical abstract: Isolation and structural determination of non-racemic tertiary cathinone derivatives
Paper

One probe, two-channel imaging of nuclear and cytosolic compartments with orange and red emissive dyes

Several new DNA-targeting probes that exhibit binding-induced ‘turn on’ fluorescence are presented.

Graphical abstract: One probe, two-channel imaging of nuclear and cytosolic compartments with orange and red emissive dyes
Paper

Calix[4]arene triazole-linked pyrene: click synthesis, assembly on graphene oxide, and highly sensitive carbaryl sensing in serum

Graphene oxide modified with a fluorescent calix[4]arene showed a highly selective recognition for carbaryl.

Graphical abstract: Calix[4]arene triazole-linked pyrene: click synthesis, assembly on graphene oxide, and highly sensitive carbaryl sensing in serum
Open Access Paper

Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells

Adenovirus type 37 (Ad37) is one of the principal agents responsible for epidemic keratoconjunctivitis (EKC), a severe ocular infection that remains without treatment.

Graphical abstract: Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells
Paper

Palladium-catalyzed direct ortho-ethoxycarbonylation of azobenzenes and azoxybenzenes with diethyl azodicarboxylate

A palladium-catalyzed direct ortho-ethoxycarbonylation of azobenzenes and azoxybenzenes with diethyl azodicarboxylate (DEAD) was developed under mild reaction conditions.

Graphical abstract: Palladium-catalyzed direct ortho-ethoxycarbonylation of azobenzenes and azoxybenzenes with diethyl azodicarboxylate
Paper

Colorful surface architectures with three different types of dynamic covalent bonds: integration of anthocyanins, tritylium ions and flavins

Complex systems with three different types of dynamic covalent bonds are probed for emergent properties.

Graphical abstract: Colorful surface architectures with three different types of dynamic covalent bonds: integration of anthocyanins, tritylium ions and flavins
Paper

Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

The biofilm state is an integral part of the lifecycle of many bacterial pathogens, but no treatments currently exist that directly impact biofilm formation or persistence. Here we report the development of a quinoline amino alcohol scaffold with both biofilm inhibitory and biofilm dispersal activities against the human pathogen Vibrio cholerae.

Graphical abstract: Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms
Paper

Photophysical and structural investigation of a PyA-modified adenine cluster: its potential use for fluorescent DNA probes exhibiting distinct emission color changes

A PyA-modified adenine cluster, exhibiting a large Stokes shift based on interstrand stacking interactions of adenines, was investigated and exploited as signaling parts of fluorescent DNA probes.

Graphical abstract: Photophysical and structural investigation of a PyA-modified adenine cluster: its potential use for fluorescent DNA probes exhibiting distinct emission color changes
Paper

Palladium-catalyzed direct C–H arylations of dioxythiophenes bearing reactive functional groups: a step-economical approach for functional π-conjugated oligoarenes

A phosphine-free C–H arylation of dioxythiophenes bearing unprotected functional groups affords oligoarenes with good yields.

Graphical abstract: Palladium-catalyzed direct C–H arylations of dioxythiophenes bearing reactive functional groups: a step-economical approach for functional π-conjugated oligoarenes
Paper

Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening

The DNA-programmed peptide display in brain extract revealed a co-operation between the binding sites on the AP-2 alpha-appendage domain.

Graphical abstract: Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening
Open Access Paper

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1

A route to enantiopure (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1, an intermediate for terpenoids, has been developed and includes a highly chemo- and regioselective Tiffeneau–Demjanov reaction.

Graphical abstract: A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1
Paper

Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold

This study reports the first synthesis of multimeric suicide inhibitors of carbonic anhydrases.

Graphical abstract: Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold
From the themed collection: Multivalent Biomolecular Recognition
Paper

Expanding the scope of N → S acyl transfer in native peptide sequences

A wider variety of Xaa-Cys motifs than originally envisaged were capable of undergoing efficient N → S acyl transfer to form thioesters and cyclic peptides, and our findings are applied to synthesis of wild-type Sunflower Trypsin Inhibitor-1 (SFTI-1).

Graphical abstract: Expanding the scope of N → S acyl transfer in native peptide sequences
Paper

Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

A novel biocompatible and macrophage cell-membrane permeable carbazole-based cyanine probe for ROS detection and cellular protection is reported.

Graphical abstract: Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection
Paper

5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling

The synthesis of 5′-methylene-[1,4]-triazole-substituted aminoribosyl uridines is described. Their biological evaluation was performed and rationalized by molecular modeling.

Graphical abstract: 5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling
Paper

Organotellurium scaffolds for mass cytometry reagent development

Tellurophenes are promising biocompatible mass tags.

Graphical abstract: Organotellurium scaffolds for mass cytometry reagent development
Paper

Direct access to site-specifically phosphorylated-lysine peptides from a solid-support

A new synthetic approach is described for the first direct synthesis of site-specifically phosphorylated Lys peptides from solid-supported azido-peptides.

Graphical abstract: Direct access to site-specifically phosphorylated-lysine peptides from a solid-support
Paper

Corrole and nucleophilic aromatic substitution are not incompatible: a novel route to 2,3-difunctionalized copper corrolates

Although corrole is an electron rich macrocycle, nucleophilic aromatic substitution reactions can be used to peripherally elaborate this contracted porphyrinoid.

Graphical abstract: Corrole and nucleophilic aromatic substitution are not incompatible: a novel route to 2,3-difunctionalized copper corrolates
112 items - Showing page 1 of 2

About this collection

This on-going collection features all the articles published in Organic and Biomolecular Chemistry in 2015 highlighted by the reviewers of the articles as being particularly interesting or particularly significant research. Congratulations to all the authors whose articles are featured!

When articles are added to this collection they will be free to access for 4 weeks.

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