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Themed collection Chemical biology in OBC

98 items - Showing page 1 of 2
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical biology in OBC
Review Article

Target specificity of mammalian DNA methylation and demethylation machinery

We review here the molecular mechanisms employed by DNMTs and TET enzymes that are responsible for shaping the DNA methylation pattern of a mammalian cell.

Graphical abstract: Target specificity of mammalian DNA methylation and demethylation machinery
From the themed collection: Chemical biology in OBC
Review Article

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups.

Graphical abstract: The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches
From the themed collection: Chemical biology in OBC
Open Access Review Article

Negishi cross-couplings in the synthesis of amino acids

The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids
From the themed collection: Chemical biology in OBC
Review Article

25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Graphical abstract: 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science
From the themed collection: Chemical biology in OBC
Communication

Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction

We report the utility of the oxa-Pictet–Spengler reaction in carbohydrates for stereoselective synthesis of sugar fused 1,2-annulated isochromans in good to excellent yields.

Graphical abstract: Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction
From the themed collection: Chemical biology in OBC
Communication

Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

The synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) was developed and it was found that some of them show inhibitory effects on human poly(ADP-ribose) polymerase-1.

Graphical abstract: Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
From the themed collection: Chemical biology in OBC
Open Access Accepted Manuscript - Communication

A pendant peptide endows a sunscreen with water-resistance

From the themed collection: Chemical biology in OBC
Communication

Two-step activity-based protein profiling of diacylglycerol lipase

Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release.

Graphical abstract: Two-step activity-based protein profiling of diacylglycerol lipase
Communication

Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence

We report the reactivity and fluorescence studies of a panel of sterically shielded tetrazoles with different N-aryl groups in the fluorogenic photoclick reaction with spiro[2.3]hex-1-ene.

Graphical abstract: Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence
From the themed collection: Chemical biology in OBC
Communication

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition.

Graphical abstract: Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89
From the themed collection: Chemical biology in OBC
Communication

The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

The first example of a counterintuitive freezing-induced peptide ligation was discovered during the total synthesis of human interferon-ε (187 amino acids) which blocks HIV infection through unique mechanisms.

Graphical abstract: The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε
From the themed collection: Chemical biology in OBC
Communication

Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Highly efficient streamlined total synthesis of complex prioritized gangliosides was achieved chemoenzymatically by sequential one-pot multienzyme (OPME) reactions with facile C18 cartridge purification schemes followed by high-yield acylation.

Graphical abstract: Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
From the themed collection: Chemical biology in OBC
Communication

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu.

Graphical abstract: Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites
From the themed collection: Chemical biology in OBC
Communication

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

A new bilirubin degradation end product was isolated and characterized.

Graphical abstract: In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product
Communication

Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation

An organocatalytic alpha-selective dehydrative glycosylation method for the synthesis of 2-deoxyglycosides.

Graphical abstract: Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation
From the themed collection: Chemical biology in OBC
Communication

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts.

Graphical abstract: Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry
From the themed collection: Chemical biology in OBC
Communication

Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

In this paper, we report the development of a new G-4 alkylating molecule and the evaluation of the properties of the alkylated G-4 DNA.

Graphical abstract: Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA
From the themed collection: Chemical biology in OBC
Communication

A double-click approach to the protecting group free synthesis of glycoconjugates

The use of a bi-functional linker, containing an alkyne and an alkene, allows the protecting group free conjugation of reducing sugars to thiols via a double click process.

Graphical abstract: A double-click approach to the protecting group free synthesis of glycoconjugates
From the themed collection: Chemical biology in OBC
Communication

Can strand displacement take place in DNA triplexes?

Toehold-mediated strand displacement can take place in the context of DNA triplexes, slowly.

Graphical abstract: Can strand displacement take place in DNA triplexes?
From the themed collection: Chemical biology in OBC
Communication

An intramolecular tryptophan-condensation approach for peptide stapling

Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position of the indole moieties via acid-mediated condensation with an aldehyde.

Graphical abstract: An intramolecular tryptophan-condensation approach for peptide stapling
From the themed collection: Chemical biology in OBC
Communication

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

Different ways to get peptides into cells.

Graphical abstract: Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability
From the themed collection: Chemical biology in OBC
Communication

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities.

Graphical abstract: Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
From the themed collection: Chemical biology in OBC
Open Access Communication

Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies

Automated glycan assembly enabled the synthesis of galactosylated xyloglucan oligosaccharides from the plant cell wall. The synthetic glycans were differentially recognized by a number of xyloglucan-directed antibodies.

Graphical abstract: Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

D-/L-isothymidine incorporation in core sequence of aptamer BC15 enhanced its binding affinity to hnRNP A1 protein

From the themed collection: Chemical biology in OBC
Paper

Glycodendron–rhenium complexes as luminescent probes for lectin sensing

Enhanced emission intensity of novel Re(I)-glycoprobes resulting from the specific recognition of carbohydrate-binding proteins as a potential tool in bioimaging applications.

Graphical abstract: Glycodendron–rhenium complexes as luminescent probes for lectin sensing
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Sialylated Variants of Lacto-N-Tetraose Exhibit Antimicrobial Activity Against Group B Streptococcus

From the themed collection: New Talent
Paper

Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria

The linear lipopeptide holrhizin is an important mediator of the Burkholderia-Rhizopus interaction that promotes bacterial colonization of the fungal host.

Graphical abstract: Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria
From the themed collection: Chemical biology in OBC
Paper

Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain

A new radiotracer for imaging TSPO: Ki, 0.70 nM and no radiolabeled metabolite in the brain.

Graphical abstract: Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain
From the themed collection: Chemical biology in OBC
Paper

Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents

The first synthetic analog of protectin D1 with potent pro-resolving and anti-inflammatory properties is reported.

Graphical abstract: Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents
From the themed collection: Chemical biology in OBC
Paper

A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation

A stable Aβ oligomer mimic that is transformed into fibrils by a chemical stimulus, i.e., an oxime exchange reaction, is disclosed.

Graphical abstract: A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation
From the themed collection: Chemical biology in OBC
Paper

Synthesis and biological activity of a CXCR4-targeting bis(cyclam) lipid

A bis(cyclam)-capped lipid, obtained through a short synthetic pathway, binds cell surface CXCR4 and prevents migration of chronic lymphocytic leukaemia cells.

Graphical abstract: Synthesis and biological activity of a CXCR4-targeting bis(cyclam) lipid
From the themed collection: Chemical biology in OBC
Open Access Paper

Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes

The fluorescence sensing mechanism for identifying single base changes in target DNA strands has been established through detailed biophysical measurements.

Graphical abstract: Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes
From the themed collection: Chemical biology in OBC
Paper

Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway

Enzymatic activity and crystal structures of the methyltransferases involved in the biosynthesis of fungal natural products meleagrin and oxaline.

Graphical abstract: Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Caged siRNAs with single folic acid modification of antisense RNA for photomodulation exogenous and endogenous gene expression in cells

From the themed collection: Chemical biology in OBC
Paper

Unusual anti-inflammatory meroterpenoids from the marine sponge Dactylospongia sp.

Nine new meroterpenoids, dactylospongins A–D, melemeleones C–E, dysidaminone N, and 19-O-methylpelorol, were isolated from the marine sponge Dactylospongia sp., which showed potent inhibitory effects on the production of IL-6, IL-1β, IL-8, and PEG2 in LPS-induced THP-1 cells with IC50 values of 5.1–9.2 μM.

Graphical abstract: Unusual anti-inflammatory meroterpenoids from the marine sponge Dactylospongia sp.
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Synthesis and Properties of Dithienylethene-Functionalized Switchable Antibacterial Agents

From the themed collection: Chemical biology in OBC
Paper

Development of G-quadruplex ligands for selective induction of a parallel-type topology

Parallel type of topology in G4 is selectively induced by tetra-guanidinylalkyl substituted 6OTD derivative.

Graphical abstract: Development of G-quadruplex ligands for selective induction of a parallel-type topology
From the themed collection: Chemical biology in OBC
Paper

Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators

New phosphotriazole cap analogues proved to enhance translation in vitro and in vivo making them applicable in the design of RNA with increased translational potential.

Graphical abstract: Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators
From the themed collection: Chemical biology in OBC
Paper

Studies on sugar puckering and glycosidic stabilities of 3′-amino-5′-carboxymethyl-3′,5′-dideoxy nucleoside mimics

Nucleoside amino acids and their dimers show a predilection of these backbone modified molecules towards an N-type conformation with a slightly weaker glycosidic linkage.

Graphical abstract: Studies on sugar puckering and glycosidic stabilities of 3′-amino-5′-carboxymethyl-3′,5′-dideoxy nucleoside mimics
From the themed collection: Chemical biology in OBC
Paper

Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles

Efficient syntheses of 4-epi-galiellalactone and the corresponding activity-based probe enabled chemoproteomic studies to reveal the biological targets.

Graphical abstract: Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles
Paper

Potentiation of the activation of cholinergic receptors by multivalent presentation of ligands supported on gold nanoparticles

The multivalent presentation of carbachol-functionalized gold nanoparticles leads to a strong potentiation of native agonist effects on the corresponding cholinergic receptors.

Graphical abstract: Potentiation of the activation of cholinergic receptors by multivalent presentation of ligands supported on gold nanoparticles
From the themed collection: Chemical biology in OBC
Paper

Attenuation of guanine oxidation via DNA-mediated electron transfer in a crowded environment using small cosolutes

Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol.

Graphical abstract: Attenuation of guanine oxidation via DNA-mediated electron transfer in a crowded environment using small cosolutes
From the themed collection: Chemical biology in OBC
Open Access Paper

Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer

We present a highly-specific, rapidly activatable dual-FRET-smartprobe for the independent optical detection of metalloproteinases and thrombin in lung cancer tissue.

Graphical abstract: Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer
Accepted Manuscript - Paper

Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents

From the themed collection: Chemical biology in OBC
Paper

A highly HDAC6-selective inhibitor acts as a fluorescent probe

HDAC6 receives great attention because of its therapeutic potential for the treatment of various diseases.

Graphical abstract: A highly HDAC6-selective inhibitor acts as a fluorescent probe
From the themed collection: Chemical biology in OBC
Paper

Rational design of a highly reactive dicysteine peptide tag for fluorogenic protein labelling

Rationally designed libraries of a short helical peptide sequence containing two cysteine residues were screened kinetically for their reactivity towards complementary dimaleimide fluorogens.

Graphical abstract: Rational design of a highly reactive dicysteine peptide tag for fluorogenic protein labelling
From the themed collection: Chemical biology in OBC
Paper

Building of neomycin–nucleobase–amino acid conjugates for the inhibition of oncogenic miRNAs biogenesis

Neomycin–nucleobase–amino acid conjugates bind to pre-miR-372 and inhibit Dicer-mediated processing thus leading to decreased levels of oncogenic miR-372 in vitro and in gastric adenocarcinoma cells.

Graphical abstract: Building of neomycin–nucleobase–amino acid conjugates for the inhibition of oncogenic miRNAs biogenesis
From the themed collection: Chemical biology in OBC
Paper

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

γ-Thionorleucine is synthesized and used for N-terminal chemical protein modification by native chemical ligation–desulfurization to prepare linear diubiquitin.

Graphical abstract: Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation
From the themed collection: Chemical biology in OBC
Paper

Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation

Four new α-glucosidase inhibitors have been synthesised through 5–8 synthetic steps from a common synthetic intermediate obtained through a recently developed carbocyclisation.

Graphical abstract: Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation
From the themed collection: Chemical biology in OBC
Open Access Paper

Quinoline–galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

Straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives and evaluation of binding affinities towards a panel of human galectins lead to the discovery of selective and potent inhibitors of the N-terminal domain of galectin-8.

Graphical abstract: Quinoline–galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
From the themed collection: Chemical biology in OBC
Paper

Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists

A strategy to diversely functionalize the C7-position of DMXAA has been developed as a means to discover potential human-STING agonists.

Graphical abstract: Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists
From the themed collection: Chemical biology in OBC
Paper

Tsavoenones A–C: unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense

Three racemic polyketides with a novel scaffold are reported from the lichen Parmotrema tsavoense.

Graphical abstract: Tsavoenones A–C: unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense
From the themed collection: Chemical biology in OBC
Open Access Paper

Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates

Synthesis and systematic study of T7 RNA polymerase incorporation of base-modified ribonucleotides for the enzymatic synthesis of modified RNA.

Graphical abstract: Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates
From the themed collection: Chemical biology in OBC
Paper

Formation of Nα-terminal 2-dialkyl amino oxazoles from guanidinated derivatives under mild conditions

Oxazole-containing peptides are an important class of molecules in medicinal chemistry programs.

Graphical abstract: Formation of Nα-terminal 2-dialkyl amino oxazoles from guanidinated derivatives under mild conditions
From the themed collection: Chemical biology in OBC
Paper

Structure–activity relationship of novel low-generation dendrimers for gene delivery

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.

Graphical abstract: Structure–activity relationship of novel low-generation dendrimers for gene delivery
From the themed collection: Chemical biology in OBC
Paper

Light-responsive bicyclic peptides

In this paper, we describe a method for the synthesis of light-responsive (LR) bicyclic macrocycles from linear peptides composed of 20 natural amino acids.

Graphical abstract: Light-responsive bicyclic peptides
From the themed collection: Chemical biology in OBC
Open Access Paper

Investigations into the biosynthesis of the antifungal strobilurins

Prestrobilurin A, formed via benzoate and cinnamate, has been identified as the first enzyme free intermediate in strobilurin biosynthesis.

Graphical abstract: Investigations into the biosynthesis of the antifungal strobilurins
From the themed collection: Chemical biology in OBC
Paper

Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches

cis-2-Aminocyclohexanecarboxylic acid replacements at the edges of β-sandwiches reduce β-sheet propensities just enough to prevent aggregation but still maintain a compact structure.

Graphical abstract: Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches
Open Access Paper

Protected 2′-deoxyribonucleoside triphosphate building blocks for the photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA

2′-Deoxyribonucleoside triphosphates containing 5-(hydroxymethyl)cytosine protected with photocleavable groups were prepared and studied as substrates for the enzymatic synthesis of DNA containing a photocaged epigenetic 5hmC base.

Graphical abstract: Protected 2′-deoxyribonucleoside triphosphate building blocks for the photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA
From the themed collection: Chemical biology in OBC
Open Access Paper

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives

Downsizing of antibodies: molecular construction of chemo-synthetic antibodies of infliximab by scaffolding of three CDR loops yields synthetic antibodies binding hTNFα.

Graphical abstract: Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives
Paper

Protein–protein interactions of human glyoxalase II: findings of a reliable docking protocol

Glyoxalase II has been docked with actin and malate dehydrogenase and a direct involvement of the GlxII active site was found. The presence of GSH in the GlxII catalytic site promotes the protein–protein stabilization.

Graphical abstract: Protein–protein interactions of human glyoxalase II: findings of a reliable docking protocol
From the themed collection: Chemical biology in OBC
Paper

Bifunctional mannoside–glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands

The synthesis of glucosinolate–mannoside glycoconjugates combining both the structural features of a myrosinase substrate and a FimH ligand is described.

Graphical abstract: Bifunctional mannoside–glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands
From the themed collection: Chemical biology in OBC
Paper

Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides

High stability of intermolecular i-motif structures in lipid-modified C-oligodeoxynucleotides.

Graphical abstract: Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides
From the themed collection: Chemical biology in OBC
Paper

Synthesis of comb-shaped DNA using a non-nucleosidic branching phosphoramidite

Asymmetrically-protected branching unit enables synthesis of comb-shaped DNAs for imaging and diagnostics applications.

Graphical abstract: Synthesis of comb-shaped DNA using a non-nucleosidic branching phosphoramidite
From the themed collection: Chemical biology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

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