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Themed collection Catalysis & biocatalysis in OBC

15 items
Review Article

Catalytic asymmetric enamine protonation reaction

Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review.

Graphical abstract: Catalytic asymmetric enamine protonation reaction
Open Access Review Article

Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors

Terpenoid structural diversity is enhanced by multiproduct enzymes. Biosynthesis can be altered by switch in substrates, cofactors and pH.

Graphical abstract: Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines

The application of bifunctional catalysis for the synthesis of tetrahydro-1,2-oxazines is described.

Graphical abstract: Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Rh(III)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

Directing group ONHR preserved ortho-alkynylation under mild conditions catalyzed by rhodium is reported.

Graphical abstract: Rh(iii)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature
From the themed collection: Catalysis & biocatalysis in OBC
Communication

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones

A novel phosphine-catalyzed umpolung [3 + 2]-annulative dimerization of ynones was developed to furnish functionally rich 5-alkylidene-2-cyclopentenones.

Graphical abstract: Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones
From the themed collection: Catalysis & biocatalysis in OBC
Paper

New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes

New amino alcohol ligands suitable for immobilization on nanoparticles were successfully used in catalytic enantioselective additions of diethylzinc to aldehydes.

Graphical abstract: New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Planar chiral [2.2]paracyclophane-based phosphine–phenols: use in enantioselective [3 + 2] annulations of allenoates and N-tosylimines

Planar chiral [2.2]paracyclophane-based phosphine–phenols efficiently catalyze the [3 + 2] annulation of N-tosylimines and allenoate.

Graphical abstract: Planar chiral [2.2]paracyclophane-based phosphine–phenols: use in enantioselective [3 + 2] annulations of allenoates and N-tosylimines
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Organocatalytic asymmetric synthesis of benzazepinoindole derivatives with trifluoromethylated quaternary stereocenters by chiral phosphoric acid catalysts

An enantioselective aza-Friedel–Crafts reaction of trifluoromethyl dihydrobenzoazepinoindoles with pyrroles or indoles catalyzed by a chiral spirocyclic phosphoric acid was developed.

Graphical abstract: Organocatalytic asymmetric synthesis of benzazepinoindole derivatives with trifluoromethylated quaternary stereocenters by chiral phosphoric acid catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Organocatalytic asymmetric Michael/hemiacetalization/acyl transfer reaction of α-nitroketones with o-hydroxycinnamaldehydes: synthesis of 2,4-disubstituted chromans

An organocatalytic asymmetric synthesis of 2,4-disubstituted chroman compounds has been developed via a Michael/hemiketalization/acyl transfer reaction between o-hydroxycinnamaldehydes and α-nitroketones.

Graphical abstract: Organocatalytic asymmetric Michael/hemiacetalization/acyl transfer reaction of α-nitroketones with o-hydroxycinnamaldehydes: synthesis of 2,4-disubstituted chromans
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A regiospecific rhamnosyltransferase from Epimedium pseudowushanense catalyzes the 3-O-rhamnosylation of prenylflavonols

A novel rhamnosyltransferase and a UDP-rhamnose synthase were characterized and applied to the biosynthesis of bioactive prenylflavonol rhamnosides.

Graphical abstract: A regiospecific rhamnosyltransferase from Epimedium pseudowushanense catalyzes the 3-O-rhamnosylation of prenylflavonols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Gold catalyzed Heck-coupling of arenediazonium o-benzenedisulfonimides

An efficient gold catalyzed Heck coupling of arenediazonium o-benzenedisulfonimides is proposed. An o-benzenedisulfonimide anion enables a radical pathway that does not require the presence of photocatalysts or external oxidants.

Graphical abstract: Gold catalyzed Heck-coupling of arenediazonium o-benzenedisulfonimides
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A nickel catalyzed acceptorless dehydrogenative approach to quinolines

A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare macrocyclic nickel catalyst [Ni(MeTAA)].

Graphical abstract: A nickel catalyzed acceptorless dehydrogenative approach to quinolines
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Addition of a polyhistidine tag alters the regioselectivity of carbonyl reductase S1 from Candida magnoliae

A recombinant carbonyl reductase shows different regioselectivity with a C-terminal His-tag compared to the N-tagged enzyme toward the same triketide substrate. Highly selective synthesis of reference triketides allowed solving this conundrum.

Graphical abstract: Addition of a polyhistidine tag alters the regioselectivity of carbonyl reductase S1 from Candida magnoliae
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution

The thermostable Baeyer–Villiger monooxygenase TmCHMO and evolved mutants are viable catalysts in stereoselective reactions of structurally different ketones.

Graphical abstract: Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution
From the themed collection: Catalysis & biocatalysis in OBC
15 items

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The latest articles published in Organic and Biomolecular Chemistry related to catalysis and biocatalysis research.

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