Natural Product Reports is delighted to present a themed issue dedicated to strategies for cellular target identification of natural products.
The incredible information content of bioactive natural products, revealed in their ability to interact in a highly selective manner with often one or just a few cellular targets in the vast proteome and genome of human cells, continues to profoundly impact basic cell biology and drug discovery. Propelled by remarkable advances in synthetic chemistry, analytical chemistry, bioinformatics, and biology (various ‘omics’), the timeframe required for a natural product to be coupled to its cellular target(s) and also for identification of the minimal pharmacophore has continued to decrease. Guest-edited by Professors Daniel Romo and Jun O. Liu this themed issue covers some of the exciting advances being made toward coupling natural products to their cellular receptors that in turn impacts cell biology and drug discovery.
Articles in this web themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow in the run up to the final issue publication.