Themed collection Prolines

5 items
Focus

Applications and future of ion mobility mass spectrometry in structural biology

Ion mobility coupled to mass spectrometry (IMMS) separates gaseous ions on the basis of mass and structural properties. Hence, structural and dynamic information can be obtained for a wide variety of biomacromolecules.

Graphical abstract: Applications and future of ion mobility mass spectrometry in structural biology
From the themed collection: Prolines
Paper

Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation

Homooligomers of substituted prolines and β-prolines were synthesized and studied using CD and NMR in water and alcohols.

Graphical abstract: Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation
From the themed collection: Prolines
Paper

Conformational properties of peptides incorporating a fluorinated pseudoproline residue

Structural features of peptides incorporating one CF3-ΨPro residue were analyzed. A type-VI β-turn was observed in a short pseudotetrapeptide sequence.

Graphical abstract: Conformational properties of peptides incorporating a fluorinated pseudoproline residue
From the themed collection: Prolines
Paper

Effect of proline analogues on the conformation of elastin peptides

Three elastin model peptides containing the repetitive motif –VGVXGVG–, where X corresponds to (2S)-proline (Pro), (2S,4R)-4-hydroxy-proline (Hyp) and (2S,4R)-4-methoxy-proline (Mop), were synthesized. The peptides were investigated at molecular and supramolecular levels.

Graphical abstract: Effect of proline analogues on the conformation of elastin peptides
From the themed collection: Prolines
Paper

Straightforward asymmetric synthesis of Ala-Ψ[CF[double bond, length as m-dash]CH]-Pro, a proline-containing pseudodipeptide bearing a fluoroolefin as a peptide bond mimic

A new efficient asymmetric synthesis has been developed to obtain the relevant fluorinated pseudodipeptide Ala-Ψ[(Z)CF[double bond, length as m-dash]CH]-Pro.

Graphical abstract: Straightforward asymmetric synthesis of Ala-Ψ[CF [[double bond, length as m-dash]] CH]-Pro, a proline-containing pseudodipeptide bearing a fluoroolefin as a peptide bond mimic
From the themed collection: Prolines
5 items

About this collection

This themed collection in NJC brings an update on several issues surrounding the potential for prolines and related peptides. It aims to highlight the latest developments in the synthesis and structural elucidation of prolines and derivatives, as well as their biological activities.

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