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Themed collection Iron and zinc sensing in cells and the body

7 items
Editorial

Iron and zinc sensing in cells and the body

This editorial introduces a collection of papers presented at a symposium at King’s College London in December 2013. The Iron Metabolism Research Group organized this meeting that focused on “zinc and iron sensing in cells and tissues.

Graphical abstract: Iron and zinc sensing in cells and the body
From the themed collection: Zinc in the Biosciences
Perspective

Iron regulatory proteins and their role in controlling iron metabolism

Cellular and body iron homeostasis are regulated by iron-sensing and post-transcriptional feedback mechanisms, which control iron uptake, release, storage and heme biosythesis.

Graphical abstract: Iron regulatory proteins and their role in controlling iron metabolism
From the themed collection: Most accessed Metallomics articles
Perspective

Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation

Relationship between the architecture and stability of zinc proteins.

Graphical abstract: Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation
From the themed collection: Zinc in the Biosciences
Minireview

Analyzing free zinc(II) ion concentrations in cell biology with fluorescent chelating molecules

Chelation-induced fluorescence changes in low molecular weight molecules (probes) and genetically encoded proteins (sensors) allow for measuring fluctuations of cellular zinc(II) ion concentrations.

Graphical abstract: Analyzing free zinc(ii) ion concentrations in cell biology with fluorescent chelating molecules
From the themed collection: Zinc in the Biosciences
Minireview

Iron and oxygen sensing: a tale of 2 interacting elements?

Iron and oxygen metabolism are intimately linked with one another.

Graphical abstract: Iron and oxygen sensing: a tale of 2 interacting elements?
From the themed collection: Iron and zinc sensing in cells and the body
Minireview

Iron-sensitive fluorescent probes: monitoring intracellular iron pools

Several iron-sensitive fluorophores have been investigated in a range of cell types in order to quantify iron(II) levels in the cytosol and the cytoplasm.

Graphical abstract: Iron-sensitive fluorescent probes: monitoring intracellular iron pools
From the themed collection: Iron and zinc sensing in cells and the body
Tutorial Review

Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells

We discuss the development and application of genetically-encoded FRET sensors as attractive tools to study intracellular Zn2+ homeostasis and signaling.

Graphical abstract: Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells
From the themed collection: Iron and zinc sensing in cells and the body
7 items

About this collection

This collection of articles features work presented at a one day symposium at King’s College London in December 2013, the 45 th such meeting organised by the Iron Metabolism Group based as the college. The article collection is dedicated to iron and zinc sensing in cells and the body and is introduced in the Editorial by Professor Robert C. Hider and Professor Wolfgang Maret.

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