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Themed collection Recent HOT articles

47 items
Minireview

A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(IV) in humans

Molecular mechanisms in the body regulate the cytotoxic properties of titanium(IV) such that Ti(IV) could be bioavailable for cellular functions.

Graphical abstract: A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans
From the themed collection: Recent HOT articles
Open Access Minireview

Iron acquisition in fungal pathogens of humans

Fungal pathogens of humans acquire iron by high affinity reductive uptake, the use of siderophores, and by heme acquisition. These systems contribute to virulence to different extents in the pathogens.

Graphical abstract: Iron acquisition in fungal pathogens of humans
From the themed collection: Recent HOT articles
Minireview

Copper trafficking to the secretory pathway

Copper (Cu) is indispensible for growth and development of human organisms.

Graphical abstract: Copper trafficking to the secretory pathway
From the themed collection: Recent HOT articles
Minireview

The emerging role of lysosomes in copper homeostasis

The lysosomal system operates as a focal point where a number of important physiological processes such as endocytosis, autophagy and nutrient sensing converge.

Graphical abstract: The emerging role of lysosomes in copper homeostasis
From the themed collection: Recent HOT articles
Minireview

Defining potential roles of Pb2+ in neurotoxicity from a calciomics approach

Metal ions play crucial roles in numerous biological processes, facilitating biochemical reactions by binding to various proteins.

Graphical abstract: Defining potential roles of Pb2+ in neurotoxicity from a calciomics approach
From the themed collection: Recent HOT articles
Tutorial Review

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems.

Graphical abstract: Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
From the themed collection: Recent HOT articles
Open Access Tutorial Review

The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans

The metal transportome of Cupriavidus metallidurans. The cell of the Gram-negative bacterium is shown with the outer membrane (outermost grey line), the inner membrane lining the cytoplasm (light yellow) and the periplasm in-between. The number of metal atoms per cell is shown in the middle of the cell. Metal uptake and efflux systems for transition metal are indicated.

Graphical abstract: The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans
From the themed collection: Recent HOT articles
Critical Review

From sea squirts to squirrelfish: facultative trace element hyperaccumulation in animals

Facultative trace element hyperaccumulation in animals is reviewed, examining mechanisms of uptake and accumulation, and biological roles.

Graphical abstract: From sea squirts to squirrelfish: facultative trace element hyperaccumulation in animals
From the themed collection: Recent HOT articles
Critical Review

Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents

Metal ions and complexes can interfere with the transcellular water flow but also with the cellular transport of glycerol and hydrogen peroxide, via inhibition of the ubiquitous aquaporin channels.

Graphical abstract: Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents
From the themed collection: Recent HOT articles
Critical Review

Human Mn-superoxide dismutase inactivation by peroxynitrite: a paradigm of metal-catalyzed tyrosine nitration in vitro and in vivo

Nitration of human MnSOD at active site Tyr34 represents a biologically-relevant oxidative post-translational modification that causes enzyme inactivation.

Graphical abstract: Human Mn-superoxide dismutase inactivation by peroxynitrite: a paradigm of metal-catalyzed tyrosine nitration in vitro and in vivo
From the themed collection: Recent HOT articles
Critical Review

Interaction of Na+, K+, Mg2+ and Ca2+ counter cations with RNA

Data on the location of alkaline and alkaline earth ions at RNA from crystallography, spectroscopy and computational modeling are reviewed.

Graphical abstract: Interaction of Na+, K+, Mg2+ and Ca2+ counter cations with RNA
From the themed collection: Recent HOT articles
Open Access Critical Review

Recent structural insights into the function of copper nitrite reductases

Copper nitrite reductases (CuNiRs) catalyse the reduction of nitrite to nitric oxide as part of the denitrification pathway. In this review, we describe insights into CuNiR function from structural studies.

Graphical abstract: Recent structural insights into the function of copper nitrite reductases
From the themed collection: Recent HOT articles
Critical Review

Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds

The biosyntheses of a family of enterobactin variants – amino acid substitution, insertion, and derivatization, and macrolactone expansion – is reviewed.

Graphical abstract: Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds
From the themed collection: Recent HOT articles
Critical Review

Ferrous iron efflux systems in bacteria

Iron efflux transporters play a critical role in protecting cells from iron intoxication.

Graphical abstract: Ferrous iron efflux systems in bacteria
From the themed collection: Recent HOT articles
Critical Review

Iron and inflammation – the gut reaction

Intestinal inflammation dysregulates iron metabolism and impairs erythropoiesis, leading to the development of anemia.

Graphical abstract: Iron and inflammation – the gut reaction
From the themed collection: Recent HOT articles
Critical Review

The organoarsenical biocycle and the primordial antibiotic methylarsenite

Bacteria produce the primordial antibiotic MAs(III) with the arsM gene, and other bacteria have arsI, arsH or arsP resistance genes.

Graphical abstract: The organoarsenical biocycle and the primordial antibiotic methylarsenite
From the themed collection: Recent HOT articles
Critical Review

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

We know that blood plasma contains many proteins and also other components that bind copper.

Graphical abstract: Ceruloplasmin and other copper binding components of blood plasma and their functions: an update
From the themed collection: Recent HOT articles
Critical Review

Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

This critical review focuses on one possible link between the cellular biology of lead and its neurotoxic effects: the link between Pb2+ substitution for Zn2+ in zinc-finger proteins and mental illness in adulthood.

Graphical abstract: Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health
From the themed collection: Recent HOT articles
Critical Review

The contribution of zinc to platelet behaviour during haemostasis and thrombosis

Platelets are known to be activated by exogenous zinc. Herein we discuss the potential routes for zinc entry and the role of zinc–protein interactions in platelet activation.

Graphical abstract: The contribution of zinc to platelet behaviour during haemostasis and thrombosis
From the themed collection: Recent HOT articles
Critical Review

Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity

A review of iron and cadmium transport by renal tubules highlighting common pathways and differences with their implications for health and disease.

Graphical abstract: Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity
From the themed collection: Recent HOT articles
Communication

Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells

A single nucleotide polymorphism (rs10455) in the last exon of the Dcytb gene in C282Y hemochromatosis subjects exhibited increased ferric reductase activity in transgenic CHO cells.

Graphical abstract: Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells
From the themed collection: Recent HOT articles
Communication

A systems biology approach reveals new endoplasmic reticulum-associated targets for the correction of the ATP7B mutant causing Wilson disease

This study provides new insights into understanding the interplay between ER quality control and copper transport mechanisms in Wilson disease.

Graphical abstract: A systems biology approach reveals new endoplasmic reticulum-associated targets for the correction of the ATP7B mutant causing Wilson disease
From the themed collection: Recent HOT articles
Open Access Communication

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

A unified approach to chemical imaging was used to spatially profile essential bio-elements in Caenorhabditis elegans.

Graphical abstract: High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans
From the themed collection: Recent HOT articles
Paper

Low-molecular-mass iron in healthy blood plasma is not predominately ferric citrate

The labile iron pool in blood consists of complexes with masses of 400–2500 Daltons that are not ferric citrate.

Graphical abstract: Low-molecular-mass iron in healthy blood plasma is not predominately ferric citrate
From the themed collection: Recent HOT articles
Paper

Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease

Coregistering quantitative high-resolution metal imaging with fluorescence imaging identifies copper accumulation in megamitochondria within intact neuroretinal slices.

Graphical abstract: Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease
From the themed collection: Recent HOT articles
Paper

Nickel(II) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells

Nickel(II) inhibits Tet-mediated oxidation of DNA 5-methylcytosine in mammalian cells.

Graphical abstract: Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells
From the themed collection: Recent HOT articles
Paper

The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue

Metal-based drugs are gaining momentum as a rapidly developing area of medicinal inorganic chemistry.

Graphical abstract: The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue
From the themed collection: Recent HOT articles
Paper

A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans

A cytosolic copper storage protein has been identified in Streptomyces lividans and plays a role in copper tolerance once the first layer of copper resistance becomes saturated.

Graphical abstract: A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans
From the themed collection: Recent HOT articles
Paper

Calcium isotope signature: new proxy for net change in bone volume for chronic kidney disease and diabetic rats

Herein, we measure the Ca isotope ratios (44Ca/42Ca and 43Ca/42Ca) in serum and bone samples collected from rats with chronic kidney disease (CKD) or diabetes mellitus (DM).

Graphical abstract: Calcium isotope signature: new proxy for net change in bone volume for chronic kidney disease and diabetic rats
From the themed collection: Metallomics in Japan
Paper

Mechanisms of iron and copper–frataxin interactions

Investigation of the mechanisms of mitochondrial metal binding to frataxin in vitro.

Graphical abstract: Mechanisms of iron and copper–frataxin interactions
From the themed collection: Recent HOT articles
Paper

BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana

BTS family members negatively regulate the Fe deficiency response; mutants have increased Fe levels and tolerance to Fe deficiency.

Graphical abstract: BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana
From the themed collection: Recent HOT articles
Paper

Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex

A highly-simplified scenario of LF/U-fOPN interaction. The U content of the U-fOPN complexes refers to the CE-ICP/MS experiments.

Graphical abstract: Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex
From the themed collection: Recent HOT articles
Paper

Decoding the anticancer activity of VO-clioquinol compound: the mechanism of action and cell death pathways in human osteosarcoma cells

Vanadium compounds were studied in recent years by considering them as a representative of a new class of non-platinum metal anticancer drugs.

Graphical abstract: Decoding the anticancer activity of VO-clioquinol compound: the mechanism of action and cell death pathways in human osteosarcoma cells
From the themed collection: Recent HOT articles
Paper

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

One dual-function (2) and one first-generation (9) conjugate of the Fe(III) chelator desferrioxamine B (DFOB, 1) showed significant rescue of neurons in the MPTP mouse model of Parkinson's disease.

Graphical abstract: Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease
From the themed collection: Recent HOT articles
Paper

Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol

The BfrB:Bfd interaction enables a dynamic equilibrium between free cytosolic Fe2+ and Fe3+ in BfrB, which functions as a buffer to oppose large fluctuations of free cytosolic Fe2+.

Graphical abstract: Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol
From the themed collection: Recent HOT articles
Paper

Metabolomic analysis of the effects of cadmium and copper treatment in Oryza sativa L. using untargeted liquid chromatography coupled to high resolution mass spectrometry and all-ion fragmentation

Evaluation of the effect of metal exposure (cadmium/copper) on metabolic pathways of rice.

Graphical abstract: Metabolomic analysis of the effects of cadmium and copper treatment in Oryza sativa L. using untargeted liquid chromatography coupled to high resolution mass spectrometry and all-ion fragmentation
From the themed collection: Recent HOT articles
Paper

Stepwise copper(I) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions

Speciation resulting from 20 bimolecular, sequential reactions involving 20 Cu(I) ions binding to metallothionein at different pH-values is reported.

Graphical abstract: Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions
From the themed collection: Recent HOT articles
Paper

Structure–function studies of acinetobactin analogs

The siderophore pre-acinetobactin undergoes a facile 5-exo-tet cyclization to enhance iron acquisition and virulence of the pathogenic producer Acinetobacter baumannii.

Graphical abstract: Structure–function studies of acinetobactin analogs
From the themed collection: Recent HOT articles
Paper

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

Unique long-range DNA interstrand cross-links of a dinuclear platinum complex formed in the 3′–3′ direction affect its antitumor effects.

Graphical abstract: Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex
From the themed collection: Recent HOT articles
Paper

High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD

SlyD activates the release of nickel and blocks the release of zinc from the high-affinity metal site of HypB.

Graphical abstract: High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD
From the themed collection: Recent HOT articles
Paper

The effect of metalloprotein inhibitors on cellular metal ion content and distribution

Synchrotron X-ray fluorescence microscopy (SXRF) data reveal that metalloprotein inhibitors (MPi) do not significantly perturb cellular Zn content or distribution.

Graphical abstract: The effect of metalloprotein inhibitors on cellular metal ion content and distribution
From the themed collection: Recent HOT articles
Paper

Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure–function relationships and interactions of binding molecules

Knowledge about mammalian selenoproteins is increasing.

Graphical abstract: Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure–function relationships and interactions of binding molecules
From the themed collection: Recent HOT articles
Open Access Paper

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Aβ oxidation due to HO˙ production by Cu–Aβ/ascorbate changes copper coordination and leads to the self-enhancement of HO˙ production and release.

Graphical abstract: Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production
From the themed collection: Recent HOT articles
Paper

The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia

Copper loss in ischemic myocardium makes a critical contribution to the suppression of HIF-1-regulated angiogenesis.

Graphical abstract: The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia
From the themed collection: Recent HOT articles
Open Access Paper

Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity

We have exploited the natural antibacterial properties of copper ions for the discovery of novel metallo-antibiotics to target drug resistant bacteria.

Graphical abstract: Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity
From the themed collection: Recent HOT articles
Paper

Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

Enantiopure titanocene complexes exert selective antitumour activity evoking paraptosis. HPLC, MS and NMR revealed CpR2Ti(OH)(OH2)+ as the likely trigger.

Graphical abstract: Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells
From the themed collection: Recent HOT articles
Paper

The S2 Cu(I) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance

We report the solution structure of apo-CupA and establish the functional primacy of the S2 Cu(I) in cellular copper resistance.

Graphical abstract: The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance
From the themed collection: Recent HOT articles
47 items

About this collection

This themed collection features articles published in Metallomics marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.

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