Themed collection Metallomics in China

22 items
Editorial

Metallomics in China

This editorial introduces the Metallomics in China themed issue, guest edited by Hongzhe Sun.

Graphical abstract: Metallomics in China
From the themed collection: Metallomics in China
Minireview

Metallomics insights for in vivo studies of metal based nanomaterials

Rapid development of engineered nanomaterials (NMs) and growing biomedical applications necessitates new types of multifunctional NMs. Understanding behavior patterns of NMs in vivo and any potential health impacts are essential to ensure safety in the biomedical application of nanotechnologies.

Graphical abstract: Metallomics insights for in vivo studies of metal based nanomaterials
From the themed collection: Metallomics in China
Critical Review

Association of arsenic with nutrient elements in rice plants

The interactions between As and macro-nutrients, as well as micro-nutrients in rice plants, is reviewed.

Graphical abstract: Association of arsenic with nutrient elements in rice plants
From the themed collection: Metallomics in China
Communication

Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking

HpSlyD interacts with HpHypB through its insert-in-flap (IF) domain and delivers Ni2+ to HpHypB, which induces the dimerization of HpHypB and enhances its GTPase activity.

Graphical abstract: Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking
From the themed collection: Nickel in biology
Communication

Photophysical and cellular uptake properties of novel phosphorescent cyclometalated iridium(III) bipyridine D-fructose complexes

We report herein new phosphorescent iridium(III) fructose complexes; their inhibited uptake by unmodified fructose, mitochondria-localization behavior and photocytotoxic activity can be utilized in the development of new tumor-selective photodynamic therapeutics.

Graphical abstract: Photophysical and cellular uptake properties of novel phosphorescent cyclometalated iridium(iii) bipyridine d-fructose complexes
From the themed collection: Metallomics in China
Paper

Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence

The occurrence of HRPs in the proteomes of prokaryotes is found to be related to their habitats.

Graphical abstract: Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrence
From the themed collection: Metallomics in China
Paper

Binding of oxo-Cu2 clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insight

A 2.1 Å resolution crystal revealed oxo-Cu2 clusters assembly in a metal-binding cleft of NgFbpA with two-tyrosine motif as ligands.

Graphical abstract: Binding of oxo-Cu2 clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insight
From the themed collection: Metallomics in China
Paper

Effects of metal ions and disulfide bonds on the activity of phosphodiesterase from Trimeresurus stejnegeri venom

TS-PDE has one class of Zn2+ binding site and two classes of Cu2+ binding site, including the high affinity activator sites and the low affinity sites. The phosphodiesterase activity of TS-PDE relies on its disulfide bonds and bimetallic cluster.

Graphical abstract: Effects of metal ions and disulfide bonds on the activity of phosphodiesterase from Trimeresurus stejnegeri venom
From the themed collection: Metallomics in China
Paper

Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae

Cobalt and nickel metalloproteome is involved in protein metabolism, carbonhydrate metabolism and gene expression regulation. Co- and Ni-binding motifs H(X)nH, M(X)nH and H(X)nM are identified.

Graphical abstract: Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae
From the themed collection: Nickel in biology
Paper

Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteins

Spatially histidine-rich clusters (HrCs) are commonly found in proteins and their presence closely correlates with transition metal ions.

Graphical abstract: Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteins
From the themed collection: Metallomics in China
Paper

Cellular response of E. coli upon Hg2+ exposure – a case study of advanced nuclear analytical approach to metalloproteomics

2-DE, when coupled with SRXRF, was used to identify proteins of interest in E. coli upon Hg exposure.

Graphical abstract: Cellular response of E. coli upon Hg2+ exposure – a case study of advanced nuclear analytical approach to metalloproteomics
From the themed collection: Metallomics in China
Paper

The effects of EF-Ts and bismuth on EF-Tu in Helicobacter pylori: implications for an elegant timing for the introduction of EF-Ts in the elongation and EF-Tu as a potential drug target

The study suggests that elegant timing is essential for the introduction of EF-Ts into the elongation process and bismuth inhibits EF-Tu.

Graphical abstract: The effects of EF-Ts and bismuth on EF-Tu in Helicobacter pylori: implications for an elegant timing for the introduction of EF-Ts in the elongation and EF-Tu as a potential drug target
From the themed collection: Metallomics in China
Paper

Mercury modulates selenium activity via altering its accumulation and speciation in garlic (Allium sativum)

Hg can modulate Se activity via altering its distribution, accumulation and speciation in garlic which is grown under Se–Hg co-exposure conditions.

Graphical abstract: Mercury modulates selenium activity via altering its accumulation and speciation in garlic (Allium sativum)
From the themed collection: Metallomics in China
Paper

Characterization of mercury-containing protein in human plasma

Mercury-containing protein was separated and characterized by 2D-HPLC-UV–ICP-MS.

Graphical abstract: Characterization of mercury-containing protein in human plasma
From the themed collection: Metallomics in China
Paper

Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity

Due to their metal binding capacities, both SelP-H and SelM′ suppressed Zn2+-induced Aβ42 aggregation and thus exhibited antioxidant and neuroprotective functionalities.

Graphical abstract: Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity
From the themed collection: Metallomics in China
Paper

PtCl2(phen) disrupts the metal ions binding to amyloid-β peptide

PtCl2(phen) preferentially binds to the Cu2+/Zn2+ coordination site in Aβ and turns metal ions to the secondary coordination site.

Graphical abstract: PtCl2(phen) disrupts the metal ions binding to amyloid-β peptide
From the themed collection: Metallomics in China
Paper

Effect of distal histidines on hydrogen peroxide activation by manganese reconstituted myoglobin

An acceleration effect on H2O2 activation by both His-43 and His-64 in an F43H MnIIIMb mutant was firstly demonstrated.

Graphical abstract: Effect of distal histidines on hydrogen peroxide activation by manganese reconstituted myoglobin
From the themed collection: Metallomics in China
Paper

Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt

Possible mechanisms underlying vanadium compounds-induced antilipolytic effects in 3T3L1 adipocytes.

Graphical abstract: Bis(acetylacetonato)-oxovanadium(iv), bis(maltolato)-oxovanadium(iv) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt
From the themed collection: Metallomics in China
Paper

Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS

Chemical interactions of mercury species with Zn7MT-2 under physiological conditions were evaluated using mass and CD spectroscopies.

Graphical abstract: Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS
From the themed collection: Metallomics in China
Paper

Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

Cytotoxicity of combined cryptotanshinone and arsenic trioxide treatment in multiple myeloma U266 cells.

Graphical abstract: Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide
From the themed collection: Metallomics in China
Paper

The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(II) asymmetric complexes

Four ruthenium(II) asymmetric complexes were found to possess potent cellular uptake properties and induce HeLa cell apoptosis by acting on mitochondrial pathways.

Graphical abstract: The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes
From the themed collection: Metallomics in China
Paper

Vanadium compounds modulate PPARγ activity primarily by increasing PPARγ protein levels in mouse insulinoma NIT-1 cells

Vanadium compounds increase PPARγ protein and modulate PPARγ phosphorylation in NIT-1 cells.

Graphical abstract: Vanadium compounds modulate PPARγ activity primarily by increasing PPARγ protein levels in mouse insulinoma NIT-1 cells
From the themed collection: Metallomics in China
22 items

About this collection

Highlighting the growth of the field of biometal science in China, this collection of articles from Metallomics aims to provide a showcase for some of the best researchers in this area. Guest Edited by Hongzhe Sun. New articles will be added to this collection as they are published.

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