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Themed collection Most Accessed Metallomics Articles in 2016

20 articles
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Contemplating a role for titanium in organisms

The properties of titanium, especially in an oxic aqueous environment, might make a biological role difficult to recognize. New -omic technologies could reveal a specific role for this metal.

Graphical abstract: Contemplating a role for titanium in organisms
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Tutorial Review

The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans

The metal transportome of Cupriavidus metallidurans. The cell of the Gram-negative bacterium is shown with the outer membrane (outermost grey line), the inner membrane lining the cytoplasm (light yellow) and the periplasm in-between. The number of metal atoms per cell is shown in the middle of the cell. Metal uptake and efflux systems for transition metal are indicated.

Graphical abstract: The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans
From the themed collection: Recent HOT articles
Critical Review

Alpha-synuclein: relating metals to structure, function and inhibition

Alpha-synuclein has long been studied due to its involvement in the progression of Parkinson's disease (PD), a common neurodegenerative disorder, although a consensus on the exact function of this protein is elusive.

Graphical abstract: Alpha-synuclein: relating metals to structure, function and inhibition
From the themed collection: Most Accessed Metallomics Articles in 2016
Critical Review

Mechanisms of metal toxicity in plants

Metal toxicity in plants is still a global problem for the environment, agriculture and ultimately human health.

Graphical abstract: Mechanisms of metal toxicity in plants
From the themed collection: Most Accessed Metallomics Articles in 2016
Critical Review

Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer

A comprehensive overview showcasing how liposomes, nanocapsules, polymers, dendrimers, nanoparticles and nanotubes may be employed as vehicles to selectively deliver cytotoxic platinum drug payloads to tumour cells.

Graphical abstract: Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer
From the themed collection: Most Accessed Metallomics Articles in 2016
Critical Review

Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity

A review of iron and cadmium transport by renal tubules highlighting common pathways and differences with their implications for health and disease.

Graphical abstract: Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity
From the themed collection: Recent HOT articles
Communication

LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs

A novel application of advanced elemental imaging offers cutting edge in vitro assays with more predictive power on the efficacy of anticancer drugs in preclinical development compared to two dimensional cell culture models.

Graphical abstract: LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Communication

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

A unified approach to chemical imaging was used to spatially profile essential bio-elements in Caenorhabditis elegans.

Graphical abstract: High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans
From the themed collection: Recent HOT articles
Open Access Paper

Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES

A liver biopsy specimen of a Wilson's disease patient was analyzed by means of micro-X-ray fluorescence (μXRF) and X-ray absorption near edge structure spectroscopy (XANES).

Graphical abstract: Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES
Open Access Paper

Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

A report on lead and manganese in serum and erythrocytes in one of the world's largest Alzheimer's disease cohorts.

Graphical abstract: Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Paper

Surface binding, localization and storage of iron in the giant kelp Macrocystis pyrifera

Iron binding to the cell surface of marine macroalgae, such as the giant kelp Macrocystis pyrifera, through alginate carboxylate groups may have biological significance as an iron storage mechanism.

Graphical abstract: Surface binding, localization and storage of iron in the giant kelp Macrocystis pyrifera
From the themed collection: Metals in marine biochemistry
Open Access Paper

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Bioreductive platinum(IV) prodrugs target tumor hypoxia.

Graphical abstract: Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
From the themed collection: Most Accessed Metallomics Articles in 2016
Paper

Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

Without MTF1, zinc buffering by metallothioneins is reduced; hence, the sensitivity of the non-MTF1-controlled zinc-responsive transcriptome is augmented.

Graphical abstract: Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
From the themed collection: Zinc in the Biosciences
Open Access Paper

Cellular uptake of metallated cobalamins

Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS).

Graphical abstract: Cellular uptake of metallated cobalamins
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Paper

Monitoring cytosolic and ER Zn2+ in stimulated breast cancer cells using genetically encoded FRET sensors

Unexpectedly, monitoring cytosolic and ER Zn2+ using FRET sensor proteins does not support EGF–ionomycin-triggered Zn2+ waves in breast cancer cells.

Graphical abstract: Monitoring cytosolic and ER Zn2+ in stimulated breast cancer cells using genetically encoded FRET sensors
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Paper

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

A LA-ICP-MS time course study of changing metal concentrations following traumatic brain injury in mice.

Graphical abstract: A time-course analysis of changes in cerebral metal levels following a controlled cortical impact
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Paper

Boron uptake, localization, and speciation in marine brown algae

Boron uptake, speciation, localization and possible biological function is studied in two species of brown algae, Macrocystis pyrifera and Ectocarpus siliculosus.

Graphical abstract: Boron uptake, localization, and speciation in marine brown algae
From the themed collection: Metals in marine biochemistry
Open Access Paper

Newport Green, a fluorescent sensor of weakly bound cellular Zn2+: competition with proteome for Zn2+

Comparison of titration of the fluorescent metal ion sensor Newport Green acid with Zn2+ in the absence (red) and presence (blue) of cell proteome. The proteome strongly competes with Newport Green for Zn2+.

Graphical abstract: Newport Green, a fluorescent sensor of weakly bound cellular Zn2+: competition with proteome for Zn2+
From the themed collection: Most Accessed Metallomics Articles in 2016
Open Access Paper

Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion

There are two competing pathways for the metalation of metallothionein MT1a by zinc and cadmium – a beaded pathway and a clustered pathway – adopted as a function of pH.

Graphical abstract: Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion
From the themed collection: Zinc in the Biosciences
Open Access Paper

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner

Exogenous zinc induces full aggregation of washed platelet suspensions. Zinc-induced aggregation is biphasic, suggestive of secondary signalling-mediated activation.

Graphical abstract: Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner
From the themed collection: Zinc in the Biosciences
20 articles

About this collection

This themed collection features the top 20 most downloaded articles published in Metallomics in 2016. Congratulations to all of the authors whose articles have been featured.

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