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Themed collection Iron in Biology

27 items
Editorial

Iron in biology

Welcome to this Metallomics themed collection on iron in biology, guest edited by Vincenzo Abbate and Robert Hider.

Graphical abstract: Iron in biology
From the themed collection: Iron in Biology
Open Access Perspective

The workings of ferritin: a crossroad of opinions

Widely divergent views emerge on the central steps in the uptake, catalytic oxidation, and transfer of iron ions by ferritin.

Graphical abstract: The workings of ferritin: a crossroad of opinions
From the themed collection: Iron in Biology
Minireview

Intracellular iron and heme trafficking and metabolism in developing erythroblasts

Vertebrate red blood cells (RBCs) arise from erythroblasts in the human bone marrow through a process known as erythropoiesis.

Graphical abstract: Intracellular iron and heme trafficking and metabolism in developing erythroblasts
From the themed collection: Iron in Biology
Open Access Minireview

Iron homeostasis in plants – a brief overview

Iron plays a crucial role in biochemistry and is an essential micronutrient for plants and humans alike. Recent progress in the field has led to a better understanding of iron homeostasis in plants, and aided the production of high iron crops for improved human nutrition.

Graphical abstract: Iron homeostasis in plants – a brief overview
From the themed collection: Iron in Biology
Minireview

Hepcidin: a real-time biomarker of iron need

There are numerous blood-based biomarkers for assessing iron stores, but all come with certain limitations.

Graphical abstract: Hepcidin: a real-time biomarker of iron need
From the themed collection: Iron in Biology
Critical Review

The elemental role of iron in DNA synthesis and repair

Iron is an essential redox element that functions as a cofactor in many metabolic pathways.

Graphical abstract: The elemental role of iron in DNA synthesis and repair
From the themed collection: Iron in Biology
Open Access Critical Review

Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

Atopic individuals are often iron-deficient and tend to develop a Th2 dominant immune response, resulting in hyperresponsiveness to harmless antigens, termed allergens.

Graphical abstract: Linking iron-deficiency with allergy: role of molecular allergens and the microbiome
From the themed collection: Iron in Biology
Critical Review

The transferrin receptor: the cellular iron gate

The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.

Graphical abstract: The transferrin receptor: the cellular iron gate
From the themed collection: Iron in Biology
Critical Review

Heme-containing enzymes and inhibitors for tryptophan metabolism

Iron-containing enzymes such as heme enzymes play crucial roles in biological systems.

Graphical abstract: Heme-containing enzymes and inhibitors for tryptophan metabolism
From the themed collection: Iron in Biology
Critical Review

Influence of iron metabolism on manganese transport and toxicity

The structural and chemical similarities between manganese (Mn) and iron (Fe) allow the two metals to interact with each other in biological systems.

Graphical abstract: Influence of iron metabolism on manganese transport and toxicity
From the themed collection: Iron in Biology
Critical Review

Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds

The biosyntheses of a family of enterobactin variants – amino acid substitution, insertion, and derivatization, and macrolactone expansion – is reviewed.

Graphical abstract: Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds
From the themed collection: Iron in Biology
Critical Review

Ferrous iron efflux systems in bacteria

Iron efflux transporters play a critical role in protecting cells from iron intoxication.

Graphical abstract: Ferrous iron efflux systems in bacteria
From the themed collection: Iron in Biology
Critical Review

Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels

Two pairs of Fe(II) (orange) tightly bound to two putative Fe(II) bowls (forest green) may bridge neighboring protein residues (red) in each gating ring of Slo1 BKCa for channel closure. The binding of Ca(II) (green) to the gating ring or the binding of carbon monoxide to either binuclear Fe(II) bowl may disrupt the Fe(II) bridge for channel opening but retain Fe(II) in the bowl.

Graphical abstract: Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels
From the themed collection: Iron in Biology
Communication

Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells

A single nucleotide polymorphism (rs10455) in the last exon of the Dcytb gene in C282Y hemochromatosis subjects exhibited increased ferric reductase activity in transgenic CHO cells.

Graphical abstract: Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells
From the themed collection: Iron in Biology
Open Access Paper

The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus

Cytochrome P450 enzymes (P450) play essential roles in redox metabolism in all domains of life including detoxification reactions and sterol biosynthesis.

Graphical abstract: The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus
From the themed collection: Iron in Biology
Paper

Dietary iron loading negatively affects liver mitochondrial function

Dietary iron overload affects liver metabolic homeostasis, reducing mitochondrial respiratory capacity, and increasing reactive oxygen species (ROS) production, in a strain-dependent manner.

Graphical abstract: Dietary iron loading negatively affects liver mitochondrial function
From the themed collection: Iron in Biology
Paper

Defining the domains of Cia2 required for its essential function in vivo and in vitro

Systematic mutation of Cia2's conserved motifs reveals the Cia1 binding site and suggests Cia2 has an additional, currently cryptic, function.

Graphical abstract: Defining the domains of Cia2 required for its essential function in vivo and in vitro
From the themed collection: Iron in Biology
Paper

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre

Tyr58 and Trp133 play key roles in the formation and decay of the Tyr25 radical species of E. coli BFR.

Graphical abstract: Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre
From the themed collection: Iron in Biology
Paper

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects

Sickle cell disease (SCD) is an inherited blood disorder caused by a β globin gene mutation of hemoglobin (HbS). TD-1 enhances oxygen affinity and prevents sickling of SS RBCs as well as providing protection against iron oxidation.

Graphical abstract: Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects
From the themed collection: Iron in Biology
Paper

Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding

Grx4 forms a cysteine-ligated [2Fe–2S] binding complex with the transcriptional repressor Php4 to regulate transcription of iron utilization genes.

Graphical abstract: Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding
From the themed collection: Iron in Biology
Paper

Human calprotectin affects the redox speciation of iron

The metal-chelating host-defense protein human calprotectin promotes the reduction of Fe(III) to Fe(II).

Graphical abstract: Human calprotectin affects the redox speciation of iron
From the themed collection: Iron in Biology
Paper

Mechanisms of iron and copper–frataxin interactions

Investigation of the mechanisms of mitochondrial metal binding to frataxin in vitro.

Graphical abstract: Mechanisms of iron and copper–frataxin interactions
From the themed collection: Iron in Biology
Paper

BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana

BTS family members negatively regulate the Fe deficiency response; mutants have increased Fe levels and tolerance to Fe deficiency.

Graphical abstract: BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana
From the themed collection: Iron in Biology
Paper

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

One dual-function (2) and one first-generation (9) conjugate of the Fe(III) chelator desferrioxamine B (DFOB, 1) showed significant rescue of neurons in the MPTP mouse model of Parkinson's disease.

Graphical abstract: Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease
From the themed collection: Iron in Biology
Open Access Paper

Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe–S cluster assembly centers

During Fe–S cluster synthesis, oligomerization of the scaffold enables stable contacts with the iron- and sulfur-donor, with structural features predicted to facilitate cluster assembly and delivery.

Graphical abstract: Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe–S cluster assembly centers
From the themed collection: Iron in Biology
Paper

Flexible aspartates propel iron to the ferroxidation sites along pathways stabilized by a conserved arginine in Dps proteins from Mycobacterium smegmatis

Flexible aspartates propel iron to the ferroxidation centre (FOC) in miniferritins.

Graphical abstract: Flexible aspartates propel iron to the ferroxidation sites along pathways stabilized by a conserved arginine in Dps proteins from Mycobacterium smegmatis
From the themed collection: Iron in Biology
Paper

Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol

The BfrB:Bfd interaction enables a dynamic equilibrium between free cytosolic Fe2+ and Fe3+ in BfrB, which functions as a buffer to oppose large fluctuations of free cytosolic Fe2+.

Graphical abstract: Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol
From the themed collection: Iron in Biology
27 items

About this collection

This collection will highlight the latest high-impact research in iron in biology and its role in agriculture, health and disease. Covering topics such as iron uptake in microorganisms, plants and parasites, iron deficiency or overload, and iron chelation therapy as well as the role of haem and haemoproteins, iron homeostasis, iron transport and storage proteins, and Fe-S clusters. Guest Edited by Vincenzo Abbate and Robert Hider. New articles will be added to this collection as they are published.

Also of interest

Binding, Transport and Storage of Metal Ions in Biological Cells

Editors: Wolfgang Maret and Anthony Wedd

This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

http://dx.doi.org/10.1039/9781849739979

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