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Themed collection DNA Encoded Libraries

8 items
Editorial

2015 First Boston Symposium of Encoded Library Platforms

Guest Editors Robert Goodnow and Christopher Davie recap the first Boston Symposium of Encoded Library Platforms and introduce the MedChemComm web collection on ‘DNA Encoded Libraries’.

Graphical abstract: 2015 First Boston Symposium of Encoded Library Platforms
From the themed collection: DNA Encoded Libraries
Review Article

From haystack to needle: finding value with DNA encoded library technology at GSK

Innovation incubation: DNA encoded library technology (ELT) was invented in academia and biotech, but came of age in a big pharma environment.

Graphical abstract: From haystack to needle: finding value with DNA encoded library technology at GSK
From the themed collection: 2016 MedChemComm Hot Articles
Research Article

Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries

Enrichment of DNA-encoded ligands under stringent, protein-denaturing conditions is enabled by crosslinking with electrophilic or photoreactive groups.

Graphical abstract: Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries
From the themed collection: DNA Encoded Libraries
Open Access Research Article

Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold

DNA-encoded libraries based on scaffolds functionalized for DNA-compatible chemistry were synthesized by split-and-pool combinatorial chemistry. The library design was aided by a chemoinformatic filtering cascade.

Graphical abstract: Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold
From the themed collection: DNA Encoded Libraries
Research Article

Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

Discriminating between non-covalent and covalent inhibitors with SDS wash in microarray-based screen.

Graphical abstract: Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
From the themed collection: 2016 MedChemComm Hot Articles
Open Access Research Article

Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

A DNA-encoded small-molecule library was prepared using yoctoReactor technology followed by binder trap enrichment to identify selective inhibitors with nanomolar potencies against p38α MAP kinase.

Graphical abstract: Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library
From the themed collection: DNA Encoded Libraries
Research Article

Analysis of the productivity of DNA encoded libraries

Analysis of physical properties and structural diversity of 57 molecules derived from screening 5–16 DNA encoded libraries against two protein targets. DNA encoded library size is not predictive of productivity.

Graphical abstract: Analysis of the productivity of DNA encoded libraries
From the themed collection: 2016 MedChemComm Hot Articles
Research Article

Development and design of the tertiary amino effect reaction for DNA-encoded library synthesis

The tertiary amino effect reaction was explored and developed for application to DNA-encoded library synthesis.

Graphical abstract: Development and design of the tertiary amino effect reaction for DNA-encoded library synthesis
From the themed collection: DNA Encoded Libraries
8 items

About this collection

A web themed issue guest edited by Drs Robert Goodnow (AstraZeneca) and Christopher Davie (GlaxoSmithKline) highlighting some of the latest work from researchers in the field of DNA-Encoded Library Technology (ELT).

New articles will be added to this collection as they are published.

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