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Themed collection 2016 Hot Articles in Molecular BioSystems

62 items
Opinion

Understanding the chemically-reactive proteome

The reactivity of amino acid residues in proteins is context-dependent and difficult to predict.

Graphical abstract: Understanding the chemically-reactive proteome
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Integrative analysis of human omics data using biomolecular networks

Biomolecular networks, such as genome-scale metabolic models and protein–protein interaction networks, facilitate the extraction of new information from high-throughput omics data.

Graphical abstract: Integrative analysis of human omics data using biomolecular networks
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Cellular identity at the single-cell level

Single cell molecular profiling techniques decode cellular identity formation within developing complex tissues and organs in both health and disease.

Graphical abstract: Cellular identity at the single-cell level
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Library-based display technologies: where do we stand?

Display technology is a collection of methods for creating libraries of modularly coded biomolecules and submit them to directed evolution to obtain arrays of desired properties with multiple applications.

Graphical abstract: Library-based display technologies: where do we stand?
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Omics approaches to probe markers of disease resistance in animal sciences

Disease pathways can be explained into a list of biomarkers at different scales to develop applications.

Graphical abstract: Omics approaches to probe markers of disease resistance in animal sciences
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Proteomics and the search for welfare and stress biomarkers in animal production in the one-health context

Stress and welfare are important factors in animal production in the context of growing production optimization and scrutiny by the general public.

Graphical abstract: Proteomics and the search for welfare and stress biomarkers in animal production in the one-health context
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Review Article

Peptide-tags for site-specific protein labelling in vitro and in vivo

Peptide-tag based labelling can be achieved by (i) enzymes (ii) recognition of metal ions or small molecules and (iii) peptide–peptide interactions and enables site-specific protein visualization to investigate protein localization and trafficking.

Graphical abstract: Peptide-tags for site-specific protein labelling in vitro and in vivo
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Metabolomics in diabetic complications

In the past 15 years, the field of metabolomics has expanded the current understanding of the pathophysiology of diabetic complications far beyond oxidative stress and inflammation. Branched-chain amino acids, phospholipid metabolism, and the glutamine/glutamate cycle are just a few of the previously unknown pathways and biomarkers of diabetes which have come to light due to advancements in sensitivity, sample preparation, and data processing.

Graphical abstract: Metabolomics in diabetic complications
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Review Article

Getting to know the extracellular vesicle glycome

Extracellular vesicles (EVs) are a diverse population of complex biological particles with diameters ranging from approximately 20 to 1000 nm. EVs carry a variety of oligosaccharides and polysaccharides as well as carbohydrate-binding molecules.

Graphical abstract: Getting to know the extracellular vesicle glycome
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Communication

High-throughput production of a stable isotope-labeled peptide library for targeted proteomics using a wheat germ cell-free synthesis system

Development of a reference peptide library for selected reaction monitoring (SRM)-based targeted proteomics using a high-throughput protein synthesis system.

Graphical abstract: High-throughput production of a stable isotope-labeled peptide library for targeted proteomics using a wheat germ cell-free synthesis system
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Communication

Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes

Localisation of a neutral rhenium(I) tricarbonyl phenanthroline species to regions of high polar lipid concentrations is demonstrated by Fourier transform infrared (FTIR) microspectroscopy.

Graphical abstract: Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Communication

A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1)

Glutathione S-transferase Pi (GSTP1) mediates cellular defense against reactive electrophiles.

Graphical abstract: A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1)
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Communication

Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3

SUMO-fused and intein-fused protein expression systems have been combined to prepare a dual-color labeled ubiquitin sensor for detecting UCH-L3's activity.

Graphical abstract: Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Communication

Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1

Unconditional deletion of RF1 in a genomically recoded E. coli enables multisite noncanonical amino acid incorporation by UAG suppression.

Graphical abstract: Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Communication

Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag

A novel approach utilizing a chemically cleavable Dde-based tag is employed herein to quantitatively label and release O-GlcNAcylated proteins for the mass spectrometric identification of previously unknown glycosylation sites.

Graphical abstract: Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Communication

Signalling to the nucleus under the control of light and small molecules

One major regulatory mechanism in cell signalling is the spatio-temporal control of the localization of signalling molecules. We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small molecules.

Graphical abstract: Signalling to the nucleus under the control of light and small molecules
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Communication

Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile

‘Barcoding’ how bacteria bind to simple sugar-surfaces using a training algorithm is used as a powerful identification tool.

Graphical abstract: Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Allosteric mechanism of cyclopropylindolobenzazepine inhibitors for HCV NS5B RdRp via dynamic correlation network analysis

The fluctuation correlation network of M2/NS5B includes some hub nodes and the information flow can freely transfer through this network.

Graphical abstract: Allosteric mechanism of cyclopropylindolobenzazepine inhibitors for HCV NS5B RdRp via dynamic correlation network analysis
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Paper

Biological processing of dinuclear ruthenium complexes in eukaryotic cells

The biological processing, including the effect on the cytoplasmic membrane, of dinuclear polypyridylruthenium(II) complexes has been examined in eukaryotic cells.

Graphical abstract: Biological processing of dinuclear ruthenium complexes in eukaryotic cells
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.

Graphical abstract: More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins

Knots in proteins have been proposed to resist proteasomal degradation, thought in turn to be related to neurodegenerative diseases such as Huntington.

Graphical abstract: Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Virucidal activity of human α- and β-defensins against hepatitis C virus genotype 4

We revealed that human α- and β-defensins have strong anti-HCV activity in experiments on cellular protection, neutralization, and treatment at low concentrations, whereas synthetic linear avian defensins could reach similar anti-HCV potential only at noticeably higher concentrations.

Graphical abstract: Virucidal activity of human α- and β-defensins against hepatitis C virus genotype 4
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening

Through the combined virtual and high content drug screening, BIPM was identified as a novel and potent ROCK2 inhibitor. Exposure of SH-SY5Y cells to BIPM led to significant changes in neurite length, cell migration and actin stress fibers via mediating ROCK2 downstream proteins.

Graphical abstract: Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Paper

Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation

Topological and functional analyses of Chlamydomonas metabolic network offers insight into fluidity of gene-pair co-conservation dynamics.

Graphical abstract: Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices

Reversible protonation of histidine at the dimer interface of HucR controls interconversion between molten globule and compact folded state.

Graphical abstract: Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

RF-Hydroxysite: a random forest based predictor for hydroxylation sites

Protein hydroxylation is an emerging posttranslational modification involved in both normal cellular processes and a growing number of pathological states, including several cancers.

Graphical abstract: RF-Hydroxysite: a random forest based predictor for hydroxylation sites
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Analyzing ERK 1/2 signalling and targets

The ERK cascade (e.g. Raf-1) protects the heart from cell death and ischemic injury but can also turn maladaptive.

Graphical abstract: Analyzing ERK 1/2 signalling and targets
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

The unique functional role of the C–H⋯S hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase

Unique C–H⋯S hydrogen bonding interactions allow nature to attain recognition specificity between molecular interfaces where there is no apparent scope for classical hydrogen bonding or polar interactions.

Graphical abstract: The unique functional role of the C–H⋯S hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Network analysis and cross species comparison of protein–protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics

Analysis of protein–protein interaction networks of CYP proteins of human, mouse and rat gives insights about functionality and species differences.

Graphical abstract: Network analysis and cross species comparison of protein–protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer

Family with sequence similarity 20, member C (Fam20C) is a physiological Golgi casein kinase that phosphorylates multiple secreted proteins.

Graphical abstract: Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Detection of driver pathways using mutated gene network in cancer

A mutated gene network is constructed based on a new mutual exclusivity index and coverage for detecting driver pathways.

Graphical abstract: Detection of driver pathways using mutated gene network in cancer
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Stabilization of epigenetic states of CpG islands by local cooperation

DNA methylation at CpG sites is an epigenetic mark that correlates with gene expresssion. Dense regions of CpG sites, so-called CpG islands, are often either fully methylated or fully unmethylated, hinting at a bistable dynamical process by which sites undergo coordinated methylation activity. We here explore a process by which CpG sites can protect others from becoming methylated, thereby re-enforcing the bistable dynamics.

Graphical abstract: Stabilization of epigenetic states of CpG islands by local cooperation
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

TMEM45B promotes proliferation, invasion and migration and inhibits apoptosis in pancreatic cancer cells

Silencing of TMEM45B induces apoptosis and suppresses invasion and migration in pancreatic cancer cells.

Graphical abstract: TMEM45B promotes proliferation, invasion and migration and inhibits apoptosis in pancreatic cancer cells
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Paper

Simultaneous tracing of carbon and nitrogen isotopes in human cells

Analyzing isotopes in multiple elements of metabolites can shed light on the coordination of carbon and nitrogen metabolism.

Graphical abstract: Simultaneous tracing of carbon and nitrogen isotopes in human cells
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Interactions of omeprazole-based analogues with cytochrome P450 2C19: a computational study

Cytochrome P450 2C19 (CYP2C19) is one of 57 drug metabolizing enzymes in humans and is responsible for the metabolism of ∼7–10% of drugs in clinical use.

Graphical abstract: Interactions of omeprazole-based analogues with cytochrome P450 2C19: a computational study
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling

Validation of novel chemical probes containing photoreactive crosslinking groups and biotin or click reporters is reported for the proteomic study of HDAC complexes.

Graphical abstract: Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Benzimidazole covalent probes and the gastric H+/K+-ATPase as a model system for protein labeling in a copper-free setting

Synthesis and use of benzimidazole activity-based probes to validate target labeling and identify novel binding partners.

Graphical abstract: Benzimidazole covalent probes and the gastric H+/K+-ATPase as a model system for protein labeling in a copper-free setting
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Paper

Effects of mono- and divalent metal ions on DNA binding and catalysis of human apurinic/apyrimidinic endonuclease 1

Here, we used stopped-flow fluorescence techniques to conduct a comparative kinetic analysis of the conformational transitions in human apurinic/apyrimidinic endonuclease 1 (APE1) and in DNA containing an abasic site in the course of their interaction.

Graphical abstract: Effects of mono- and divalent metal ions on DNA binding and catalysis of human apurinic/apyrimidinic endonuclease 1
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Functional correlations of respiratory syncytial virus proteins to intrinsic disorder

The respiratory syncytial virus proteome is highly enriched in intrinsically disordered regions, which confer many functional advantages.

Graphical abstract: Functional correlations of respiratory syncytial virus proteins to intrinsic disorder
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism

We reconstructed hepatitis C virus assembly reactions to find host-target metabolites impeding this reaction.

Graphical abstract: Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

A lipidomics investigation into the intervention of celastrol in experimental colitis

Celastrol significantly alleviated DSS-induced colitis in mice. Lipidomics highlights alteration of several lipid markers associated with colitis. Celastrol treatment recovered SCD1 expression and restored the levels of lipid markers.

Graphical abstract: A lipidomics investigation into the intervention of celastrol in experimental colitis
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

[Ru(bpy)2(7-CH3-dppz)]2+ and [Ru(phen)2(7-CH3-dppz)]2+ as metallointercalators that affect third-strand stabilization of the poly(U)˙poly(A)*poly(U) triplex

Ru1 and Ru2 not only can stabilize the triplex, but also can serve as molecular “light switches” for the triplex. In addition, the two complexes stabilizing third-strand is weaker, reflecting the binding of Ru1 and Ru2 with the triplex is favored by the Watson–Crick base-paired duplex.

Graphical abstract: [Ru(bpy)2(7-CH3-dppz)]2+ and [Ru(phen)2(7-CH3-dppz)]2+ as metallointercalators that affect third-strand stabilization of the poly(U)˙poly(A)*poly(U) triplex
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes

Silencing of USP22 suppresses high glucose-induced podocyte injury.

Graphical abstract: Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Stability analysis of the ODE model representation of amyloidogenic processing in Alzheimer's disease in the presence of SORLA

The proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in the formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer's disease (AD).

Graphical abstract: Stability analysis of the ODE model representation of amyloidogenic processing in Alzheimer's disease in the presence of SORLA
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

The binding landscape of plasmepsin V and the implications for flap dynamics

Plasmepsin V belongs to the plasmepsin family of aspartic proteases.

Graphical abstract: The binding landscape of plasmepsin V and the implications for flap dynamics
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response

A number of mathematical models of apoptosis generated recently allowed us to understand intrinsic mechanisms of life/death decisions in a cell.

Graphical abstract: Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Revisiting and re-engineering the classical zinc finger peptide: consensus peptide-1 (CP-1)

Zinc plays key structural and catalytic roles in biology.

Graphical abstract: Revisiting and re-engineering the classical zinc finger peptide: consensus peptide-1 (CP-1)
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Open Access Paper

3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells

R = H, acyl; X = H, D; Y = H, phosphate, phosphocholine, glucose, or lactose.

Graphical abstract: 3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Assessing the ligand selectivity of sphingosine kinases using molecular dynamics and MM-PBSA binding free energy calculations

Three residues of SK1 were identified important for selective SK1 inhibitory activity via SK2 homology model building, molecular dynamics simulation, and MM-PBSA studies.

Graphical abstract: Assessing the ligand selectivity of sphingosine kinases using molecular dynamics and MM-PBSA binding free energy calculations
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Interaction mechanism exploration of HEA derivatives as BACE1 inhibitors by in silico analysis

The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates the generation of β-amyloid (Aβ) peptides which play a critical early role in the pathogenesis of Alzheimer's disease (AD), and thus it is a prime target for lowering the Aβ levels to treat AD.

Graphical abstract: Interaction mechanism exploration of HEA derivatives as BACE1 inhibitors by in silico analysis
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Patch formation of a viral channel forming protein within a lipid membrane – Vpu of HIV-1

Dimer-first formation leads to larger assemblies with potentially relevant structures.

Graphical abstract: Patch formation of a viral channel forming protein within a lipid membrane – Vpu of HIV-1
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Sequence diversity and ligand-induced structural rearrangements of viper hyaluronidase

The study focuses on ligand-induced structural changes of viper hyaluronidase and also provides insight into structure-based drug design for eukaryotic hyaluronidases, which could be future drug targets in cancer treatment, and venom spreading.

Graphical abstract: Sequence diversity and ligand-induced structural rearrangements of viper hyaluronidase
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Signatures of protein thermal denaturation and local hydrophobicity in domain specific hydration behavior: a comparative molecular dynamics study

We investigate, using atomistic molecular dynamics simulations, the association of surface hydration accompanying local unfolding in the mesophilic protein Yfh1 under a series of thermal conditions spanning its cold and heat denaturation temperatures.

Graphical abstract: Signatures of protein thermal denaturation and local hydrophobicity in domain specific hydration behavior: a comparative molecular dynamics study
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Principal elementary mode analysis (PEMA)

Principal elementary mode analysis (PEMA), provides an easy way to identify metabolic patterns in large fluxomics datasets in terms of the simplest pathways of the organism metabolism

Graphical abstract: Principal elementary mode analysis (PEMA)
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells

eEF2K, a unique calcium/calmodulin-dependent protein kinase, may regulate ER stress in cancer.

Graphical abstract: Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis

Increased mitogen-activated protein kinase (MAPK) activity has been found in human osteoarthritis (OA).

Graphical abstract: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Identifying the crosstalk of dysfunctional pathways mediated by lncRNAs in breast cancer subtypes

Crosstalk among abnormal pathways widely occurs in human cancer and generally leads to insensitivity to cancer treatment.

Graphical abstract: Identifying the crosstalk of dysfunctional pathways mediated by lncRNAs in breast cancer subtypes
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Molecular recognition features (MoRFs) in three domains of life

MoRFs are widespread intrinsically disordered protein-binding regions that have similar abundance and amino acid composition across the three domains of life.

Graphical abstract: Molecular recognition features (MoRFs) in three domains of life
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Understanding the combinatorial action of transcription factors and microRNA regulation from regions of open chromatin

Transcriptional regulatory cascades are always triggered through the combinatorial interplay between transcription factors (TFs) and microRNAs (miRNAs) in eukaryotes.

Graphical abstract: Understanding the combinatorial action of transcription factors and microRNA regulation from regions of open chromatin
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis

This work constitutes the first known report on lncRNA expression patterns of ectopic and eutopic endometrial tissues in human adenomyosis.

Graphical abstract: The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study

L-type Ca2+ channels (LTCCs), the heteromultimeric proteins, are associated with electrical signaling and provide the key link between electrical signals and non-electrical processes.

Graphical abstract: Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study
From the themed collection: 2016 Hot Articles in Molecular BioSystems
Paper

Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan

In this work we performed the first transcriptional study of a filamentous fungus (N. crassa) in response to chitosan.

Graphical abstract: Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan
From the themed collection: 2016 Hot Articles in Molecular BioSystems
62 items

About this collection

This on-going collection features all the articles published in Molecular BioSystems in 2016 highlighted by the reviewers of the articles as being particularly interesting or particularly significant research. Congratulations to all the authors whose articles are featured!

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