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Themed collection Open access articles recently published in Lab on a Chip

50 articles
Open Access Frontier

Microfluidic blood plasma separation for medical diagnostics: is it worth it?

This review weights the advantages and limits of miniaturised blood plasma separation and highlights interesting advances in direct biomarker capture.

Graphical abstract: Microfluidic blood plasma separation for medical diagnostics: is it worth it?
Open Access Frontier

Oscillatory multiphase flow strategy for chemistry and biology

Oscillatory multiphase flow strategy enables the utilization of droplet microfluidics for studies of longer timescale processes than typically feasible with conventional continuous multiphase flow approaches in chemistry and biology, by decoupling mixing and residence times.

Graphical abstract: Oscillatory multiphase flow strategy for chemistry and biology
Open Access Tutorial Review

Integration and application of optical chemical sensors in microbioreactors

This tutorial review explains the integration of optical chemical sensor formats for the purpose of monitoring oxygen, pH, carbon dioxide, glucose and temperature in microbioreactors.

Graphical abstract: Integration and application of optical chemical sensors in microbioreactors
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Tutorial Review

Microfluidic platforms for DNA methylation analysis

This review discusses epigenetics and the microfluidic platforms developed for DNA methylation analysis.

Graphical abstract: Microfluidic platforms for DNA methylation analysis
Open Access Critical Review

Mobile microrobots for bioengineering applications

Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic devices with live cells.

Graphical abstract: Mobile microrobots for bioengineering applications
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Polymerase chain reaction in microfluidic devices

Developments of microfluidic-based time/space domain PCR, digital PCR, and isothermal nucleic acid amplification.

Graphical abstract: Polymerase chain reaction in microfluidic devices
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

CMOS biosensors for in vitro diagnosis – transducing mechanisms and applications

Architecture and operation of different CMOS biomolecule transducing mechanisms.

Graphical abstract: CMOS biosensors for in vitro diagnosis – transducing mechanisms and applications
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

3D printed microfluidic devices: enablers and barriers

3D printing has the potential to significantly change the field of microfluidics.

Graphical abstract: 3D printed microfluidic devices: enablers and barriers
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

This review focuses on developments in the field of droplet microfluidics in the context of drug discovery, genomics and transcriptomics.

Graphical abstract: Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Communication

Multiplexed droplet Interface bilayer formation

A movable PMMA device to reversibly form droplet interface bilayers (DIBs).

Graphical abstract: Multiplexed droplet Interface bilayer formation
Open Access Communication

Dynamics of bacterial streamers induced clogging in microfluidic devices

Bacterial streamer induced clogging regime is characterized by stick-slip fronts and instabilities resulting in formation of water channels.

Graphical abstract: Dynamics of bacterial streamers induced clogging in microfluidic devices
Open Access Communication

Continuous on-chip fluorescence labelling, free-flow isoelectric focusing and marker-free isoelectric point determination of proteins and peptides

Presented are microfluidic chips that allow for continuous subsequent biomolecular labelling, free-flow isoelectric focusing and real-time isoelectric point monitoring.

Graphical abstract: Continuous on-chip fluorescence labelling, free-flow isoelectric focusing and marker-free isoelectric point determination of proteins and peptides
Open Access Communication

Tacky cyclic olefin copolymer: a biocompatible bonding technique for the fabrication of microfluidic channels in COC

A fast and cost-efficient process for bonding of COC for the fabrication of biologically functionalized microfluidic channels is presented.

Graphical abstract: Tacky cyclic olefin copolymer: a biocompatible bonding technique for the fabrication of microfluidic channels in COC
Open Access Communication

Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications

The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on CaOx crystalline phases is studied using a microfluidic channel.

Graphical abstract: Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications
Open Access Paper

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.

Graphical abstract: Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans

A new automated microfluidic platform can deliver a wide range of mechanical stimuli for functional neural imaging in C. elegans.

Graphical abstract: Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans
Open Access Paper

A simple and highly sensitive spectroscopic fluorescence-detection system for multi-channel plastic-microchip electrophoresis based on side-entry laser-beam zigzag irradiation

Fluorescence from eight A channels and Raman-scattered light from seven B channels, induced by a side-entry laser beam, were simultaneously, uniformly, and spectroscopically detected.

Graphical abstract: A simple and highly sensitive spectroscopic fluorescence-detection system for multi-channel plastic-microchip electrophoresis based on side-entry laser-beam zigzag irradiation
Open Access Paper

On-chip enzymatic microbiofuel cell-powered integrated circuits

A CMOS based digital circuit that is powered by an integrated on-chip enzymatic microbiofuelcell.

Graphical abstract: On-chip enzymatic microbiofuel cell-powered integrated circuits
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry

We present an original five-electrode coplanar chip enabling accurate particle sizing without the need for focusing.

Graphical abstract: Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry
Open Access Paper

Digital DNA detection based on a compact optofluidic laser with ultra-low sample consumption

DNA lasers self-amplify optical signals from a DNA analyte as well as thermodynamic differences between sequences, allowing quasi-digital DNA detection.

Graphical abstract: Digital DNA detection based on a compact optofluidic laser with ultra-low sample consumption
Open Access Paper

Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations

Artificial control of bio-nanomachines should have a major impact on the development of controllable transport systems for specific cargo transport on chips.

Graphical abstract: Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations
Open Access Paper

DROPLAY: laser writing of functional patterns within biological microdroplet displays

In this study, we introduce an optofluidic method for the rapid construction of large-area cell-sized droplet assemblies with user-defined re-writable two-dimensional patterns of functional droplets.

Graphical abstract: DROPLAY: laser writing of functional patterns within biological microdroplet displays
Open Access Paper

The microfluidic lighthouse: an omnidirectional gradient generator

Omnidirectional flow devices for quantitative analysis of chemotactic reorientation and steering in fast migrating cells such as Dictyostelium and neutrophils.

Graphical abstract: The microfluidic lighthouse: an omnidirectional gradient generator
Open Access Paper

Rapid, portable and cost-effective yeast cell viability and concentration analysis using lensfree on-chip microscopy and machine learning

We demonstrate a field-portable and automatic yeast analysis platform that can rapidly measure cell concentration and viability using on-chip microscopy and machine learning.

Graphical abstract: Rapid, portable and cost-effective yeast cell viability and concentration analysis using lensfree on-chip microscopy and machine learning
Open Access Paper

Electrochemical DNA biosensors based on long-range electron transfer: investigating the efficiency of a fluidic channel microelectrode compared to an ultramicroelectrode in a two-electrode setup

Forced convection decreases the diffusion layer thickness on microelectrode and promotes a faster DNA collection.

Graphical abstract: Electrochemical DNA biosensors based on long-range electron transfer: investigating the efficiency of a fluidic channel microelectrode compared to an ultramicroelectrode in a two-electrode setup
Open Access Paper

Additively manufactured MEMS multiplexed coaxial electrospray sources for high-throughput, uniform generation of core–shell microparticles

This study reports the first MEMS multiplexed coaxial electrospray sources in the literature. The devices demonstrate a low-cost, uniform, and high-throughput microencapsulation technology that is compatible with big-market applications such as drug delivery, food processing, self-healing composites, and dye-sensitized solar cells.

Graphical abstract: Additively manufactured MEMS multiplexed coaxial electrospray sources for high-throughput, uniform generation of core–shell microparticles
Open Access Paper

Fully automated chemiluminescence detection using an electrified-Lab-on-a-Disc (eLoaD) platform

Wireless power technology for centrifugal microfluidics to bridge the gap between Lab-on-a-Disc and Lab-on-a-Chip by placing the sensors in the frame of reference of the spinning disc.

Graphical abstract: Fully automated chemiluminescence detection using an electrified-Lab-on-a-Disc (eLoaD) platform
Open Access Paper

Dielectric elastomer actuator for mechanical loading of 2D cell cultures

We demonstrate the first DEA-based deformable bioreactor, generating up to 35% uniaxial tensile strain on living cells.

Graphical abstract: Dielectric elastomer actuator for mechanical loading of 2D cell cultures
Open Access Paper

Autonomous microfluidic capillaric circuits replicated from 3D-printed molds

We recently developed capillaric circuits (CCs) – advanced capillary microfluidic devices assembled from capillary fluidic elements in a modular manner similar to the design of electric circuits (Safavieh & Juncker, Lab Chip, 2013, 13, 4180–4189).

Graphical abstract: Autonomous microfluidic capillaric circuits replicated from 3D-printed molds
Open Access Paper

Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids

We present a new microfluidic protocol for spheroid based assays that combines the compartmentalisation properties of droplet microfluidics with controllable perfusion typical of single-phase microfluidics.

Graphical abstract: Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids
Open Access Paper

Real-time assessment of nanoparticle-mediated antigen delivery and cell response

Single-cell microfluidics enables real-time monitoring of nanomaterial–cell interaction dynamics.

Graphical abstract: Real-time assessment of nanoparticle-mediated antigen delivery and cell response
Open Access Paper

Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating

A GO-induced 3D nanoporous PDA surface coating was developed to substantially improve the sensitivity of immuno-detection of circulating exosomes directly in clinical samples.

Graphical abstract: Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating
Open Access Paper

Efficient analysis of a small number of cancer cells at the single-cell level using an electroactive double-well array

The electroactive double well-array consists of trap-wells for highly efficient single-cell trapping using dielectrophoresis (cell capture efficiency of 96 ± 3%) and reaction-wells that confine cell lysates for analysis of intracellular materials from single cells.

Graphical abstract: Efficient analysis of a small number of cancer cells at the single-cell level using an electroactive double-well array
Open Access Paper

Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples

Processing of stool samples using an IFAST microfluidic device for the genetic analysis of infectious pathogens such as H. pylori.

Graphical abstract: Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples
Open Access Paper

Evaluating 3D printing to solve the sample-to-device interface for LRS and POC diagnostics: example of an interlock meter-mix device for metering and lysing clinical urine samples

Rapid prototyping of a meter-mix device to accurately meter, lyse, and transfer urine samples for LRS and POC diagnostics.

Graphical abstract: Evaluating 3D printing to solve the sample-to-device interface for LRS and POC diagnostics: example of an interlock meter-mix device for metering and lysing clinical urine samples
Open Access Paper

On-chip analysis, indexing and screening for chemical producing bacteria in a microfluidic static droplet array

We present a screening platform that couples a microfluidic static droplet array (SDA) and an artificial riboswitch to analyze intracellular metabolite concentration from single microbial cells.

Graphical abstract: On-chip analysis, indexing and screening for chemical producing bacteria in a microfluidic static droplet array
Open Access Paper

On-chip microtubule gliding assay for parallel measurement of tau protein species

Rapid on-chip detection of tau isoforms, their ratios and mutants by measuring the fluorescent intensity of microtubules in a kinesin-coated microfluidic device.

Graphical abstract: On-chip microtubule gliding assay for parallel measurement of tau protein species
Open Access Paper

Polydimethylsiloxane (PDMS) modulates CD38 expression, absorbs retinoic acid and may perturb retinoid signalling

All-trans retinoic acid (ATRA) is absorbed by PDMS and depleted from culture media, influencing gene expression and phenotype across a range of cell types.

Graphical abstract: Polydimethylsiloxane (PDMS) modulates CD38 expression, absorbs retinoic acid and may perturb retinoid signalling
Open Access Paper

Assessment of colorimetric amplification methods in a paper-based immunoassay for diagnosis of malaria

We have evaluated the impact of readout time and the ease-of-perception on accurate interpretation of colorimetric readouts in immunoassays.

Graphical abstract: Assessment of colorimetric amplification methods in a paper-based immunoassay for diagnosis of malaria
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Continuous cell sorting in a flow based on single cell resonance Raman spectra

A chip-based Raman activated cell sorting system is developed, which demonstrates continuous and automated sorting of individual cells in a flow, based on their intrinsic resonance Raman spectra. This platform allows the isolation of cells in their native fluid with the ability to achieve high accuracy sorting of 96.3%.

Graphical abstract: Continuous cell sorting in a flow based on single cell resonance Raman spectra
Open Access Paper

LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering

We present a centrifugal microfluidic LabDisk for protein structure analysis via small-angle X-ray scattering (SAXS) on synchrotron beamlines.

Graphical abstract: LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering
Open Access Paper

Enhanced versatility of fluid control in centrifugal microfluidic platforms using two degrees of freedom

Two degrees of freedom allow independent access to identical burst valves, unlimited inward and outward pumping, and targeted flow switching.

Graphical abstract: Enhanced versatility of fluid control in centrifugal microfluidic platforms using two degrees of freedom
Open Access Paper

A microfluidic, dual-purpose sensor for in vitro detection of Enterobacteriaceae and biotinylated antibodies

A bacteria and antibody biosensor where friction is for the first time used for resolving biomolecules.

Graphical abstract: A microfluidic, dual-purpose sensor for in vitro detection of Enterobacteriaceae and biotinylated antibodies
Open Access Paper

Pyrosequencing on a glass surface

We demonstrated DNA pyrosequencing at the plain hydrophobically coated surface of a microscope glass cover slip using open-surface microfluidics.

Graphical abstract: Pyrosequencing on a glass surface
Open Access Paper

On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging

We present the first on-chip atomisation-like production of phase-change contrast agents at high concentrations towards high-resolution contrast imaging for diagnostic ultrasound.

Graphical abstract: On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging
Open Access Paper

Handheld real-time PCR device

World's smallest, fully autonomous, handheld real-time PCR was shown in this contribution. The device can quickly process up to four samples at a time with detection capability of a single DNA copy. The fully integrated system includes all required electronics for fluorescence measurement, data viewing (LCD display) and processing, and is ideal for use in small clinics and point-of-care applications.

Graphical abstract: Handheld real-time PCR device
Open Access Paper

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as a promising biomarker source for cancer diagnosis via a less invasive procedure.

Graphical abstract: A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis
Open Access Paper

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

3D printing enables the rapid and cost-efficient manufacturing of bespoke, complex prototypes. We show that biocompatibility needs to be considered carefully and provide a specific assay to that effect.

Graphical abstract: Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays
Open Access Paper

On-chip automation of cell-free protein synthesis: new opportunities due to a novel reaction mode

The microfluidic device for cell-free protein synthesis enables a novel reaction mode with continuous in vitro transcription and translation in separate compartments combined by magnetic and microfluidic actuated mRNA transfer.

Graphical abstract: On-chip automation of cell-free protein synthesis: new opportunities due to a novel reaction mode
Open Access Paper

LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus

Sample supply remains the only manual handling step for pathogen detection at the point-of-care.

Graphical abstract: LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
50 articles

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