Themed collection Speciation Analysis

Guest Editors, Heidi Goenaga-Infante and Gunda Koellensperger, introduce the 2016 speciation themed issue.

Metalloproteins, which represent about 30% of the total proteome, are often important markers for distinguishing between healthy and diseased states of patients.

This review will focus specifically on the state of the art of novel sample pretreatment methods which have been combined with ICP-MS based hyphenated techniques for elemental speciation in biological samples.

Electrophoresis in capillaries/microchannels interfaced with inductively coupled plasma spectrometries shows great potential in elemental speciation and interaction with ligands, and indirect determination by taking advantage of both separation and detection.

Monolithic supports are efficient stationary phases for most of the important chromatographic separation modes.

Turbulent flow chromatography is a powerful technique for efficient on-line separation of proteins from low molecular weight compounds.

Orpiment and realgar are two artists' pigments that appear not to be stable upon light exposure, quickly degrading to arsenic trioxide and arsenate. Their identification appears challenging but can be overcome by the use of synchrotron based techniques such as μ-XANES.

Systematic approach for the accurate quantification of selenoproteins (SEPP1) in human plasma/serum by IDA-LC-ICP-MS.

Thioredoxin reductase 1 (TrxR1) is a cytosolic and extracellular enzyme involved in cellular redox homeostasis and other important biological functions for cell survival.

Determination of free methionine in human blood plasma by HPLC-ICP-MS using ³⁴S-labelled methionine as species-specific spike.

Quantification of pharmaceutical peptides in human plasma by RP-LC-ICP-MS and post column isotope dilution.

This study describes the identification and quantification of five new arsenolipids present in raw marine fish oil extracted mainly from Peruvian anchoveta (Engraulis ringens).

The capability of FFF online with ICP-MS detection was extended to the determination of particulate carbon via validation against FFF-OCD.

This work demonstrated the coupling of monolith-based electrochromatography in microchips with ICP-MS for elemental speciation.

A species-specific ID-ICP-MS method for intact haemoglobin was developed applying an ⁵⁷Fe enriched haemoglobin spike, which was prepared and characterised carefully.

Production of ³⁴S enriched amino acids using yeast.

This paper provides first quantitative speciation data for chromium in tobacco and tobacco smoke by using complementary HLPC-ICP-MS and XANES.

This work introduces and evaluates the use of recombinantly produced antigen binding fragments (Fab) for ICP-MS based immunoassays.

In this work, we present the first methodical approach to the preparation, molecular characterization and use of a novel type of full-length human selenoprotein standard.

Species-specific double and triple isotope dilution mass spectrometry (IDMS) was applied for the precise quantification of Cu,Zn-SOD in human erythrocytes.