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Themed collection Integrative Biology Most Downloaded Articles

10 articles
Open Access Review Article

New advances in probing cell–extracellular matrix interactions

This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.

Graphical abstract: New advances in probing cell–extracellular matrix interactions
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

T cell immunoengineering with advanced biomaterials

Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.

Graphical abstract: T cell immunoengineering with advanced biomaterials
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells

Aptamer-functionalized nano/micro-materials have enabled efficient cell-specific recognition, isolation, release and complete subsequent characterization for future clinical therapy guidance.

Graphical abstract: Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

Next generation of network medicine: interdisciplinary signaling approaches

We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.

Graphical abstract: Next generation of network medicine: interdisciplinary signaling approaches
From the themed collection: Integrative Biology Recent Review Articles
Review Article

CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects

The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA and to modulate expression levels of genes of interest, thus providing powerful tools to accelerate the precise engineering of a wide range of organisms.

Graphical abstract: CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Liquid biopsy on chip: a paradigm shift towards the understanding of cancer metastasis

This review provides a framework for development of on-chip liquid biopsy platforms for capture, detection, and analysis of circulating tumor cells.

Graphical abstract: Liquid biopsy on chip: a paradigm shift towards the understanding of cancer metastasis
From the themed collection: Integrative Biology Recent Review Articles
Review Article

New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.

Graphical abstract: New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling
From the themed collection: Integrative Biology Recent Review Articles
Paper

Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device

Creating vascular networks in tissues is crucial for tissue engineering.

Graphical abstract: Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device
From the themed collection: Integrative Biology Most Downloaded Articles
Paper

Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography

We provide a dynamic perspective of how nanotopography regulate adhesions at the single molecular level.

Graphical abstract: Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography
From the themed collection: Integrative Biology Most Downloaded Articles
Paper

PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity

The effects of systematic microenvironmental changes on melanoma drug responsiveness were assessed and found to depend on the stage of progression and culture conditions.

Graphical abstract: PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity
From the themed collection: Integrative Biology Most Downloaded Articles
10 articles

About this collection

This web collection features the top 10 most downloaded articles published in Integrative Biology in January-August 2017. Congratulations to all of the authors whose articles have been featured!

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