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Themed collection Open access articles recently published in Integrative Biology

15 items
Open Access Review Article

Exploring DNA–protein interactions on the single DNA molecule level using nanofluidic tools

This review highlights the use of nanofluidic channels for studying DNA–protein interactions on the single DNA molecule level.

Graphical abstract: Exploring DNA–protein interactions on the single DNA molecule level using nanofluidic tools
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

New advances in probing cell–extracellular matrix interactions

This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.

Graphical abstract: New advances in probing cell–extracellular matrix interactions
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

T cell immunoengineering with advanced biomaterials

Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.

Graphical abstract: T cell immunoengineering with advanced biomaterials
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

Next generation of network medicine: interdisciplinary signaling approaches

We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.

Graphical abstract: Next generation of network medicine: interdisciplinary signaling approaches
From the themed collection: Integrative Biology Recent Review Articles
Open Access Review Article

The appeasement of Doug: a synthetic approach to enhancer biology

In this review, we discuss how we can use synthetic approaches to study animal enhancers, as well as the importance of both positive and negative results for advancing the field of developmental gene regulation.

Graphical abstract: The appeasement of Doug: a synthetic approach to enhancer biology
Open Access Review Article

Nature versus design: synthetic biology or how to build a biological non-machine

We suggest that progress in synthetic biology will be achieved by abandoning the bio-machine paradigm and by using an alliance between engineering and evolution as a guiding tool.

Graphical abstract: Nature versus design: synthetic biology or how to build a biological non-machine
Open Access Paper

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

Lmna knockout causes an impaired actin stress fiber organization which results in a fivefold lower contractile stress generation.

Graphical abstract: Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts
Open Access Paper

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

Multi-functional scaling is a mechanistic framework to design integrated microphysiological systems for pharmacological applications.

Graphical abstract: Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)
Open Access Paper

Template-assisted extrusion of biopolymer nanofibers under physiological conditions

Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions.

Graphical abstract: Template-assisted extrusion of biopolymer nanofibers under physiological conditions
Open Access Paper

Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia

We construct a pathway de novo for microenvironment-specific genetic regulators of acute lymphoblastic leukemia using RNAi screening, and mRNA data.

Graphical abstract: Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
Open Access Paper

Three-dimensional hierarchical cultivation of human skin cells on bio-adaptive hybrid fibers

Bio-adaptive hybrid fibers simulating the complex biomechanical characteristics of the native human extracellular matrix were developed as bio-inspired functional materials for biomedical applications.

Graphical abstract: Three-dimensional hierarchical cultivation of human skin cells on bio-adaptive hybrid fibers
Open Access Paper

Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry

Mechanical measurements of skeletal stem cells using RT-DC reveal a distinct sub-population within the human bone marrow.

Graphical abstract: Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry
Open Access Paper

Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets

Using 1D arrangements of microdroplets to exchange chemical messages between cell-free systems and bacteria.

Graphical abstract: Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets
Open Access Paper

Fully quantified spectral imaging reveals in vivo membrane protein interactions

Fully quantified spectral imaging is a new tool for probing the stoichiometry and stability of protein complexes in biological membranes.

Graphical abstract: Fully quantified spectral imaging reveals in vivo membrane protein interactions
Open Access Paper

Mimicking the topography of the epidermal–dermal interface with elastomer substrates

Micro-scale topography mimics stem cell patterning in human interfollicular epidermal stem cells.

Graphical abstract: Mimicking the topography of the epidermal–dermal interface with elastomer substrates
From the themed collection: Integrative Biology Recent HOT Articles
15 items

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