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Themed collection Integrative Biology Recent HOT Articles

60 articles
Perspective

Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs

How do regenerating bodies know when to stop remodeling? Bioelectric signaling networks guide pattern formation and may implement a somatic memory system. Deep parallels may exist between information processing in the brain and morphogenetic control mechanisms.

Graphical abstract: Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs
From the themed collection: Integrative Biology Recent Review Articles
Perspective

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

We here bring together data on a variety of diseases in which both hypercoagulability and hypofibrinolysis occur simultaneously, implying that the processes are linked.

Graphical abstract: The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)
From the themed collection: Integrative Biology Recent Review Articles
Frontier

A journey to uncharted territory: new technical frontiers in studying tumor–stromal cell interactions

The complexities of tumor–stroma interactions necessitate new means of analysis. This review details emerging imaging and genetic methods that hold promise to provide unprecedented insight into tumor–stroma crosstalk.

Graphical abstract: A journey to uncharted territory: new technical frontiers in studying tumor–stromal cell interactions
From the themed collection: Integrative Biology Recent Review Articles
Review Article

New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.

Graphical abstract: New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

Organ-on-a-chip and organoid culture models present complementary approaches in studying development and disease by balancing experimental tractability and the ability to mimic physiological complexity.

Graphical abstract: Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Using synthetic biology to make cells tomorrow's test tubes

We present various exciting examples of synthetic biology as a means to distill biological systems to their essential features in order to make them theoretically tractable.

Graphical abstract: Using synthetic biology to make cells tomorrow's test tubes
From the themed collection: Integrative Biology Recent Review Articles
Review Article

From noise to synthetic nucleoli: can synthetic biology achieve new insights?

Synthetic biology builds new systems not only for applications but also to understand biology, achieving fundamental insights in the process.

Graphical abstract: From noise to synthetic nucleoli: can synthetic biology achieve new insights?
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Synthetic biology: applying biological circuits beyond novel therapies

Synthetic biology, an engineering, circuit-driven approach to biology, has developed whole new classes of tools that can be used together to create novel mock systems, fine-tuned in vivo reporters, spatially and temporally inducible models and closed-loop systems often leading to previously unattainable biological insights.

Graphical abstract: Synthetic biology: applying biological circuits beyond novel therapies
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Build to understand: synthetic approaches to biology

In this review we discuss how synthetic biology facilitates the task of investigating genetic circuits that are observed in naturally occurring biological systems.

Graphical abstract: Build to understand: synthetic approaches to biology
From the themed collection: Integrative Biology Recent Review Articles
Critical Review

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies.

Graphical abstract: Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
From the themed collection: Integrative Biology Recent Review Articles
Paper

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function

Synthetic 3D matrix binds cell-secreted matrix and mimics endometrial epithelial–stromal tissue architecture, hormone responsiveness, and cytokine production.

Graphical abstract: Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

Hyaluronan, CD44 and the Receptor for Hyaluronan-Mediated Motility (RHAMM, gene name HMMR) regulate stem cell differentiation including mesenchymal progenitor differentiation.

Graphical abstract: Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

A novel microsphere-based flow cytometry approach to study adherent cell signaling responses in different microenvironmental contexts at the single cell level.

Graphical abstract: Microsphere cytometry to interrogate microenvironment-dependent cell signaling
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Patterning of sharp cellular interfaces with a reconfigurable elastic substrate

This simple device employs an elastic substrate to pattern a sharp border between two adjoining cell populations.

Graphical abstract: Patterning of sharp cellular interfaces with a reconfigurable elastic substrate
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Identification and isolation of antigen-specific cytotoxic T lymphocytes with an automated microraft sorting system

The simultaneous measurement of T cell function with recovery of individual T cells would greatly facilitate characterizing antigen-specific responses both in vivo and in model systems.

Graphical abstract: Identification and isolation of antigen-specific cytotoxic T lymphocytes with an automated microraft sorting system
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays

A combinatorial cell microarray platform to map the impact of both extracellular matrix proteins and genotype on the drug responses of tumor cells.

Graphical abstract: Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics

α-Ketoglutarate substrate inhibition kinetics of hepatic glutamate dehydrogenase amination activity confers robust control over the ratio between glutamate and ammonium.

Graphical abstract: Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics
From the themed collection: Integrative Biology Recent HOT Articles
Paper

A multiphysics model of the Pacinian corpuscle

This study integrates mechanics and neuroscience to model the mechanoelectrochemical transduction of vibrations into neural signals in the Pacinian corpuscle.

Graphical abstract: A multiphysics model of the Pacinian corpuscle
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Nanoscale mechanics guides cellular decision making

Nanoscale tension gauges revealed how substrate stiffness alters pico Newton force thresholds that trigger initial cell attachment, spreading, and adhesion maturation.

Graphical abstract: Nanoscale mechanics guides cellular decision making
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Dynamic transcription factor activity networks in response to independently altered mechanical and adhesive microenvironmental cues

Large-scale arrays of transcription factor activity reveal differential responses to chemical and mechanical aspects of the extracellular environment.

Graphical abstract: Dynamic transcription factor activity networks in response to independently altered mechanical and adhesive microenvironmental cues
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

Fiber alignment within tumor-mimetic engineered collagen matrices drives FAK- and Rac1-dependent cellular anisotropy that promotes protrusions along fibers and suppresses off-axis protrusions to direct cell migration.

Graphical abstract: Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK
From the themed collection: Integrative Biology Recent HOT Articles
Paper

PDMS microwells for multi-parametric monitoring of single mitochondria on a large scale: a study of their individual membrane potential and endogenous NADH

PDMS microwell platforms provide an innovative approach to better characterize the dynamics of metabolic activities in single mitochondria within a population.

Graphical abstract: PDMS microwells for multi-parametric monitoring of single mitochondria on a large scale: a study of their individual membrane potential and endogenous NADH
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor

We demonstrated in a microfluidic system that initiation of clotting of flowing human whole blood overcomes a patch threshold response to stimuli patch size when tissue factor and von Willebrand factor are present.

Graphical abstract: Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Optimizing micropattern geometries for cell shape and migration with genetic algorithms

Adhesive micropatterns have become a standard tool to control cell shape and function in cell culture.

Graphical abstract: Optimizing micropattern geometries for cell shape and migration with genetic algorithms
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform

A microwell system for detection of secreted products from adherent cells is used to demonstrate that macrophage adhesive context and cell shape regulate cytokine secretion and population heterogeneity.

Graphical abstract: Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform
From the themed collection: Integrative Biology Recent HOT Articles
Open Access Paper

Vinculin head–tail interaction defines multiple early mechanisms for cell substrate rigidity sensing

Vinculin head–tail interaction regulates rigidity-dependent cell branching and recruitment of talin, but not of paxillin or FAK.

Graphical abstract: Vinculin head–tail interaction defines multiple early mechanisms for cell substrate rigidity sensing
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF

Total internal reflection fluorescence microscopy (TIRF) and Qdot probe based analytical method for the simultaneous evaluation of the cytotoxic ability of camptothecin and the drug resistance profile upon the inhibition of drug efflux pumps in breast cancer stem cells.

Graphical abstract: Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination

Germination of a population of pathogenic fungal spores into yeast can be tracked, quantified, and parsed using a microfluidic assay.

Graphical abstract: Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle

Bidirectional coupling between a synthetic oscillator and the bacterial cell cycle leads to their mutual entrainment.

Graphical abstract: Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle
From the themed collection: Integrative Biology Recent HOT Articles
Open Access Paper

Label-free concentration of viable neurons, hESCs and cancer cells by means of acoustophoresis

Concentration of viable cell populations in suspension is of interest for several clinical and pre-clinical applications.

Graphical abstract: Label-free concentration of viable neurons, hESCs and cancer cells by means of acoustophoresis
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Conserved roles for cytoskeletal components in determining laterality

Consistently-biased left–right (LR) patterning is required for the proper placement of organs including the heart and viscera.

Graphical abstract: Conserved roles for cytoskeletal components in determining laterality
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization

Artificial antigen presenting cells with clustered T cell ligands were prepared and used to reveal a dual scale of T cell response: a local nano-scale response in which the cell redistributes key signalling molecules, and a global cell scale response according to the average ligand density.

Graphical abstract: Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

This work identifies the molecular mechanisms by which interstitial fluid pressure drives collective invasion in an engineered model of solid human tumors.

Graphical abstract: Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin
From the themed collection: Integrative Biology Recent HOT Articles
Paper

A 3D alcoholic liver disease model on a chip

A spheroid-based in vitro 3D ALD model with perfusion culture can establish the reversible and irreversible states of ALD.

Graphical abstract: A 3D alcoholic liver disease model on a chip
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line

Inositol hexakisphosphate (InsP6 or IP6) is an important signalling molecule. An IP6 probe was synthesised from myo-inositol and immobilised onto Dynabeads for proteomic analysis. LC/MS/MS analysis identified 77 proteins or protein complexes that bind to IP6 specifically.

Graphical abstract: Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Intracellular singlet oxygen photosensitizers: on the road to solving the problems of sensitizer degradation, bleaching and relocalization

Can we control the photosensitized production of intracellular singlet oxygen?

Graphical abstract: Intracellular singlet oxygen photosensitizers: on the road to solving the problems of sensitizer degradation, bleaching and relocalization
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Stoichiometric control of live cell mixing to enable fluidically-encoded co-culture models in perfused microbioreactor arrays

A cell mixer microbioreactor array platform that permits the rapid establishment of perfused cell co-culture models in a high-throughput, programmable fashion.

Graphical abstract: Stoichiometric control of live cell mixing to enable fluidically-encoded co-culture models in perfused microbioreactor arrays
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Modeling continuum of epithelial mesenchymal transition plasticity

Mathematical modeling of plasticity expressed in EMT undergoing HaCaT cell population endorsed with molecular expressions and phenotype morphometry.

Graphical abstract: Modeling continuum of epithelial mesenchymal transition plasticity
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Capillary plexuses are vulnerable to neutrophil extracellular traps

We show that the trapping of neutrophil-derived chromatin fibres at the entrance of microchannel networks in vitro can result in the formation of disproportionately large areas with no RBC traffic.

Graphical abstract: Capillary plexuses are vulnerable to neutrophil extracellular traps
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform

Development of a biofunctionalized three-dimensional hydrogel scaffold for hepatoctye cell culture highlights the importance of cell morphology, more specifically sheet-layer formation, in regulating gene expression.

Graphical abstract: Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Use of protein-engineered fabrics to identify design rules for integrin ligand clustering in biomaterials

We engineered novel electrospun protein fabrics to gain insight into cellular responses to heterogeneity in global versus local ligand density.

Graphical abstract: Use of protein-engineered fabrics to identify design rules for integrin ligand clustering in biomaterials
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

A microdevice to model type 2 diabetes-like hyperglycemia in C. elegans and examine several aspects of this disease in C. elegans.

Graphical abstract: Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice
From the themed collection: Integrative Biology Recent HOT Articles
Open Access Paper

Mimicking the topography of the epidermal–dermal interface with elastomer substrates

Micro-scale topography mimics stem cell patterning in human interfollicular epidermal stem cells.

Graphical abstract: Mimicking the topography of the epidermal–dermal interface with elastomer substrates
Paper

Assessment of the potential of a high frequency acoustomicrofluidic nebulisation platform for inhaled stem cell therapy

This study demonstrates the use of a novel high frequency acoustic nebulisation platform as an effective aerosolisation technique for inhaled mesenchymal stem cell (MSC) therapy.

Graphical abstract: Assessment of the potential of a high frequency acoustomicrofluidic nebulisation platform for inhaled stem cell therapy
From the themed collection: Integrative Biology Recent HOT Articles
Paper

A microfluidic dual gradient generator for conducting cell-based drug combination assays

We present a microfluidic gradient generator that exposes cultured cells to orthogonally-aligned linear concentration gradients of two molecules. Live-cell assays quantifying apoptotic signaling and cell motility are provided as proof-of-concept.

Graphical abstract: A microfluidic dual gradient generator for conducting cell-based drug combination assays
From the themed collection: Integrative Biology Recent HOT Articles
Open Access Paper

Differentiation capacity and maintenance of differentiated phenotypes of human mesenchymal stromal cells cultured on two distinct types of 3D polymeric scaffolds

This study shows that the classical validation of hMSC differentiation potential on 3D scaffolds might not be sufficient to ensure the maintenance of the cells functionality in the absence of differentiation inducing soluble factors.

Graphical abstract: Differentiation capacity and maintenance of differentiated phenotypes of human mesenchymal stromal cells cultured on two distinct types of 3D polymeric scaffolds
From the themed collection: Integrative Biology Recent HOT Articles
Paper

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization and in vivo osteogenesis evaluation

Dopants play critical roles in controlling the physical, mechanical, degradation kinetics, and in vivo properties of brushite cements.

Graphical abstract: IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization and in vivo osteogenesis evaluation
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

Quantitative measurements of subcellular deformation in microfabricated environments provide an improved understanding of how cells overcome the resistance of the large and rigid nucleus during 3-D migration, with direct relevance to invasive cancer cells and immune cells.

Graphical abstract: Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR)

The discovery of tubulin-derived peptides that bind with high affinity to the receptor for hyaluronan mediated motility (RHAMM).

Graphical abstract: Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR)
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

Human tumors are stiff and data suggest that the extracellular matrix stiffening is consistent with experimental mammary tumor models in which stiffness drives tumor invasion and metastasis.

Graphical abstract: Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks

We developed an agent-based model of endothelial sprout initiations based on time-lapse confocal imaging in vitro that outperforms Monte Carlo simulations, suggesting that sprout location and frequency are not purely stochastic behaviors.

Graphical abstract: Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Two macrocyclic polyamines as modulators of metal-mediated Aβ40 aggregation

L1 and L2 can inhibit the metal-induced Aβ40 aggregation, attenuate neurotoxicity, suppress the intracellular ROS and protect against cell apoptosis.

Graphical abstract: Two macrocyclic polyamines as modulators of metal-mediated Aβ40 aggregation
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood

Heterogeneity of sphingosine kinase (SK) pathway activity in natural killer (NK) cells may enable cells to respond effectively to a diverse array of pathogens as well as incipient tumor cells.

Graphical abstract: Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Magnetic engineering of stable rod-shaped stem cell aggregates: circumventing the pitfall of self-bending

During the maturation process, a rod-shaped aggregate of stem cells spontaneously bends and coils into a sphere-like structure.

Graphical abstract: Magnetic engineering of stable rod-shaped stem cell aggregates: circumventing the pitfall of self-bending
From the themed collection: Integrative Biology Recent HOT Articles
Paper

A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation

This study reports a biomimetic microsystem that reconstitutes the lung microenvironment for monitoring the role of eosinophil cationic protein (ECP) in lung inflammation.

Graphical abstract: A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Axonal conduction slowing induced by spontaneous bursting activity in cortical neurons cultured in a microtunnel device

We demonstrated that spontaneous bursting activity can decrease the axonal conduction velocity of cortical neurons cultured in a microtunnel device.

Graphical abstract: Axonal conduction slowing induced by spontaneous bursting activity in cortical neurons cultured in a microtunnel device
From the themed collection: Integrative Biology Recent HOT Articles
Paper

Silk fibroin–keratin based 3D scaffolds as a dermal substitute for skin tissue engineering

Development of highly vascular dermal tissue-engineered skin substitutes with appropriate mechanical properties and cellular cues is in need for significant advancement in the field of dermal reconstruction.

Graphical abstract: Silk fibroin–keratin based 3D scaffolds as a dermal substitute for skin tissue engineering
From the themed collection: Integrative Biology Recent HOT Articles
Technical Innovation

Chemical imaging of molecular changes in a hydrated single cell by dynamic secondary ion mass spectrometry and super-resolution microscopy

Chemical imaging of single cells at the molecular level is important in capturing biological dynamics.

Graphical abstract: Chemical imaging of molecular changes in a hydrated single cell by dynamic secondary ion mass spectrometry and super-resolution microscopy
From the themed collection: Integrative Biology Recent HOT Articles
Technical Innovation

Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species

Simultaneous analysis of the production of reactive oxygen species and formation of extracellular traps from neutrophils isolated from a drop of blood using a novel microfluidics based approach.

Graphical abstract: Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species
From the themed collection: Integrative Biology Recent HOT Articles
Technical Innovation

RNA-seq based transcriptomic analysis of single bacterial cells

A RNA-seq method for single bacterial cells which not only shows reliable results but also reveals significant heterogeneity was firstly reported.

Graphical abstract: RNA-seq based transcriptomic analysis of single bacterial cells
From the themed collection: Integrative Biology Recent HOT Articles
60 articles

About this collection

Here is a collection of recent Integrative Biology articles which have been classified as ‘HOT articles’ due to receiving particularly high scores at peer review.

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