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Themed collection Continuous processing and flow chemistry in the pharmaceutical industry

7 items
Editorial

Recent advances in flow chemistry in the pharmaceutical industry

This themed issue showcases how continuous flow technology is increasingly being used in both the discovery and development of therapeutic agents.

Graphical abstract: Recent advances in flow chemistry in the pharmaceutical industry
Communication

The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design

In this paper we explore and propose a methodology for the scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions.

Graphical abstract: The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design
Communication

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described.

Graphical abstract: Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles
Paper

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

A convergent and robust synthesis of a developmental CCR1 antagonist is described using continuous flow technology.

Graphical abstract: Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement
From the themed collection: 2017 Green Chemistry Hot Articles
Paper

A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

A green approach towards the on-demand in-line generation of MNU and diazomethane in a continuous flow.

Graphical abstract: A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU
Open Access Paper

A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

A novel annular flow reactor for UV photochemistry.

Graphical abstract: A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
Paper

Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode

Hydrogen peroxide is showcased in a range of oxidations, operating in continuous-flow equipment to deliver practical and risk-minimized procedures.

Graphical abstract: Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode
7 items

About this collection

This themed issue aims to showcase recent advances in the field of continuous processing and flow chemistry technology in drug discovery and development.  This issue is guest-edited by Stefan Koenig (Genentech, a member if the Roche Group) and Helen Sneddon (GlaxoSmithKline and Green Chemistry Editorial Board member).

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