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Themed collection Foldamers

40 items
Feature Article

Exploiting the interactions of aromatic units for folding and assembly in aqueous environments

A brief description of current models of aromatic interactions as well as a survey of aromatic foldamers in aqueous environments.

Graphical abstract: Exploiting the interactions of aromatic units for folding and assembly in aqueous environments
From the themed collection: Foldamers
Feature Article

β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

A perspective on the design and elaboration of β-peptide bundles, non-natural assemblies that exhibit many protein-like properties.

Graphical abstract: β-Peptide bundles: Design. Build. Analyze. Biosynthesize.
From the themed collection: Foldamers
Open Access Feature Article

Remote control over folding by light

Integrating photoswitchable unit into helical macromolecules allows their conformations to be externally controlled by light and therefore provides a versatile strategy to design photoresponsive materials.

Graphical abstract: Remote control over folding by light
From the themed collection: Foldamers
Feature Article

Towards vast libraries of scaffold-diverse, conformationally constrained oligomers

Protein ligands with high affinity and selectivity can be mined from large libraries of conformationally constrained oligomers.

Graphical abstract: Towards vast libraries of scaffold-diverse, conformationally constrained oligomers
From the themed collection: Foldamers
Open Access Feature Article

Designing the structure and folding pathway of modular topological bionanostructures

Review of recent advances in the design of topologically folded (topofold) biomolecular nano-structures and their folding pathways.

Graphical abstract: Designing the structure and folding pathway of modular topological bionanostructures
From the themed collection: Foldamers
Feature Article

Molecular switching involving metastable states: molecular thermal hysteresis and sensing of environmental changes by chiral helicene oligomeric foldamers

Molecular switching involving metastable states by chiral helicene oligomeric foldamers exhibits notable non-equilibrium thermodynamic properties, which can be used for sensing environmental changes.

Graphical abstract: Molecular switching involving metastable states: molecular thermal hysteresis and sensing of environmental changes by chiral helicene oligomeric foldamers
From the themed collection: Foldamers
Open Access Feature Article

Dynamic foldamer chemistry

Dynamic foldamers translate chemical signals into conformational changes, and hence into chemical outputs such as control of reactivity and selectivity.

Graphical abstract: Dynamic foldamer chemistry
From the themed collection: Foldamers
Open Access Communication

Versatile ruthenium complexes based on 2,2′-bipyridine modified peptoids

Helical peptoids bearing 2,2′-bipyridine form ruthenium complexes via intermolecular binding to linear peptoid strands or intramolecular binding to a cyclic scaffold.

Graphical abstract: Versatile ruthenium complexes based on 2,2′-bipyridine modified peptoids
From the themed collection: Foldamers
Communication

Electronic interactions of i, i + 1 dithioamides: increased fluorescence quenching and evidence for n-to-π* interactions

Adjacent thioamides can have electronic interactions that alter spectral properties and fluorescence quenching.

Graphical abstract: Electronic interactions of i, i + 1 dithioamides: increased fluorescence quenching and evidence for n-to-π* interactions
From the themed collection: Foldamers
Open Access Communication

13-Helix folding of a β/γ-peptide manifold designed from a “minimal-constraint” blueprint

A bottom-up design rationale was used to select an alternating β/γ-peptide motif which folds into a well-defined 13-helix in solution.

Graphical abstract: 13-Helix folding of a β/γ-peptide manifold designed from a “minimal-constraint” blueprint
From the themed collection: Foldamers
Communication

Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin

An oligoquinoline foldamer library was synthesized and screened for agonism of lipid bilayer catalysed assembly of islet amyloid polypeptide (IAPP).

Graphical abstract: Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin
From the themed collection: Foldamers
Communication

Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents

A new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, significantly stabilizes the 11/9-helix propensity in protic solvents.

Graphical abstract: Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents
From the themed collection: Foldamers
Communication

Orthogonal strategy for the synthesis of dual-functionalised β3-peptide based hydrogels

We describe a new class of hydrogelator based on helical β3-peptide foldamers carrying a bioactive payload. The β3-peptides self-assemble to form a nanofibrous mesh resulting in a stable hydrogel. Co-incubation with different β3-peptide monomers allowed tuning of cell adherence.

Graphical abstract: Orthogonal strategy for the synthesis of dual-functionalised β3-peptide based hydrogels
From the themed collection: Foldamers
Communication

An optimal hydrogen-bond surrogate for α-helices

The manuscript describes the impact of alkene-derived hydrogen bond isosteres on the stability of constrained helices.

Graphical abstract: An optimal hydrogen-bond surrogate for α-helices
From the themed collection: Foldamers
Open Access Communication

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

An extended sequence of α-amino acids in HIF-1α is replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide to reproduce its p300 recognition properties.

Graphical abstract: Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
From the themed collection: Foldamers
Communication

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

A small molecule promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise do not form duplexes.

Graphical abstract: Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones
From the themed collection: Foldamers
Communication

Unambiguous characterization of anisotropic foldamer packing in a foldecture with an elongated hexagonal plate shape

We report the first complete characterization of the directional molecular packing patterns of individual foldamers within a new foldecture with a well defined hexagonal plate shape.

Graphical abstract: Unambiguous characterization of anisotropic foldamer packing in a foldecture with an elongated hexagonal plate shape
From the themed collection: Foldamers
Communication

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported.

Graphical abstract: Self-assembly of a 5-fluorouracil-dipeptide hydrogel
From the themed collection: Foldamers
Communication

Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell.

Graphical abstract: Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein
From the themed collection: Foldamers
Communication

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Design, synthesis, single-crystal conformations and molecular aggregations of hybrid triple-stranded β-sheets, and their structural analogy with protein structures are reported.

Graphical abstract: Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals
From the themed collection: Foldamers
Communication

A nanofiber assembly directed by the non-classical antiparallel β-structure from 4S-(OH) proline polypeptide

The antiparallel arrangement of two strands of the non-classical β-structure, formed exclusively via cis-4S-(OH) prolyl polypeptide as established by FRET, propagates into self-assembled nanofibers upon conjugation with C12/C14/C16 hydrocarbon chains.

Graphical abstract: A nanofiber assembly directed by the non-classical antiparallel β-structure from 4S-(OH) proline polypeptide
From the themed collection: Foldamers
Communication

Structural studies of β-turn-containing peptide catalysts for atroposelective quinazolinone bromination

X-Ray crystallography and NMR spectroscopy were used to investigate the effect of primary structure on both secondary structure and enantioselectivity in peptide-based catalysts for an atroposelective bromination reaction.

Graphical abstract: Structural studies of β-turn-containing peptide catalysts for atroposelective quinazolinone bromination
From the themed collection: Foldamers
Open Access Communication

X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair

DNA duplexes containing unnatural base-pair surrogates are attractive biomolecular nanomaterials with potentially beneficial photophysical or electronic properties.

Graphical abstract: X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair
From the themed collection: Foldamers
Communication

Improved chemical and mechanical stability of peptoid nanosheets by photo-crosslinking the hydrophobic core

Photo-crosslinking produced more robust nanosheets that can survive sonication, lyophilization, and other biochemical manipulations.

Graphical abstract: Improved chemical and mechanical stability of peptoid nanosheets by photo-crosslinking the hydrophobic core
From the themed collection: Foldamers
Communication

Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

β-Peptide foldamers were functionalised with the cell recognition motifs RGD or IKVAV, self-assembled into fibres, and co-assembled with non-functionalised β-peptides to yield tunable bioscaffolds with cell adhering properties.

Graphical abstract: Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds
From the themed collection: Foldamers
Communication

Weak backbone CHO[double bond, length as m-dash]C and side chain tButBu London interactions help promote helix folding of achiral NtBu peptoids

The synthesis and helix folding propensity of achiral all-cis amide (NtBu)-glycine oligomers is reported.

Graphical abstract: Weak backbone CH⋯O [[double bond, length as m-dash]] C and side chain tBu⋯tBu London interactions help promote helix folding of achiral NtBu peptoids
From the themed collection: Foldamers
Communication

Aryl-triazole foldamers incorporating a pyridinium motif for halide anion binding in aqueous media

Aryl-triazole foldamers incorporating a pyridinium motif are shown to be strongly halide anion binding in aqueous solvent mixtures.

Graphical abstract: Aryl-triazole foldamers incorporating a pyridinium motif for halide anion binding in aqueous media
From the themed collection: Foldamers
Communication

Hairpin ribozyme mediated RNA recombination

An engineered hairpin ribozyme supports the recombination of two non-functional substrates into a functional hammerhead ribozyme.

Graphical abstract: Hairpin ribozyme mediated RNA recombination
From the themed collection: Foldamers
Open Access Communication

Hydrogen bonding to carbonyl oxygen of nitrogen-pyramidalized amide – detection of pyramidalization direction preference by vibrational circular dichroism spectroscopy

Hydrogen-bonding to carbonyl of nitrogen-pyramidalized bicyclic β-proline amides can switch the preferred nitrogen-pyramidalization direction, as detected by VCD spectroscopy.

Graphical abstract: Hydrogen bonding to carbonyl oxygen of nitrogen-pyramidalized amide – detection of pyramidalization direction preference by vibrational circular dichroism spectroscopy
From the themed collection: Foldamers
Communication

Citric acid encapsulation by a double helical foldamer in competitive solvents

Self-assembly combined with folding generate cavities for large polar guests.

Graphical abstract: Citric acid encapsulation by a double helical foldamer in competitive solvents
From the themed collection: Foldamers
Communication

Comparison of design strategies for α-helix backbone modification in a protein tertiary fold

Structural and thermodynamic analysis of a family of synthetic proteins with heterogeneous backbones yields new insights into the ability of unnatural amino acids to be accommodated into α-helices.

Graphical abstract: Comparison of design strategies for α-helix backbone modification in a protein tertiary fold
From the themed collection: Foldamers
Communication

Folding-induced exciton coupling in homo- and heterodimers of merocyanine dyes

Folding of a bis(merocyanine) dye with two different chromophores leads to a model system to elucidate electronic interactions in heteroaggregates.

Graphical abstract: Folding-induced exciton coupling in homo- and heterodimers of merocyanine dyes
From the themed collection: Foldamers
Communication

Surprising impact of remote groups on the folding–unfolding and dimer-chain equilibria of bifunctional H-bonding unimers

The remote end groups of aromatic foldamers are found to profoundly impact the assembling propensity of these molecules.

Graphical abstract: Surprising impact of remote groups on the folding–unfolding and dimer-chain equilibria of bifunctional H-bonding unimers
From the themed collection: Foldamers
Communication

Modulation of helix stability of indolocarbazole–pyridine hybrid foldamers

The kinetic stabilities of the helical conformations of indolocarbazole–pyridine hybrid foldamers were modulated through single site modification.

Graphical abstract: Modulation of helix stability of indolocarbazole–pyridine hybrid foldamers
From the themed collection: Foldamers
Communication

Foldameric probes for membrane interactions by induced β-sheet folding

The adjustment of β-sheet content by β-amino acid substitutions revealed β-sheet folding-dependent biological activity.

Graphical abstract: Foldameric probes for membrane interactions by induced β-sheet folding
From the themed collection: Foldamers
Communication

Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists

We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues.

Graphical abstract: Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists
From the themed collection: Foldamers
Communication

In situ iodination and X-ray crystal structure of a foldamer helix bundle

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods.

Graphical abstract: In situ iodination and X-ray crystal structure of a foldamer helix bundle
From the themed collection: Foldamers
Communication

Helix handedness inversion in arylamide foldamers: elucidation and free energy profile of a hopping mechanism

The free energy landscape and conformations of minima and intermediates along the stepwise handedness inversion pathway, proceeding through the simultaneous unfolding/folding of adjacent monomer–monomer linkages, for a helical arylamide foldamer.

Graphical abstract: Helix handedness inversion in arylamide foldamers: elucidation and free energy profile of a hopping mechanism
From the themed collection: Foldamers
Communication

Dynamic DNA architectures: spontaneous DNA strand exchange and self-sorting driven by perylene bisimide interactions

Three differently bay-substituted perylene bisimides together with the conventional unsubstituted chromophore were synthetically incorporated as homodimers in DNA double strands and undergo spontaneous strand exchange if mixed together.

Graphical abstract: Dynamic DNA architectures: spontaneous DNA strand exchange and self-sorting driven by perylene bisimide interactions
From the themed collection: Foldamers
Open Access Communication

The discovery of 9/8-ribbons, β/γ-peptides with curved shapes governed by a combined configuration-conformation code

The design of a β/γ-peptide reveals an unprecedented 9/8-ribbon whose curvature depends on the β-residue configuration and the γ-residue conformation.

Graphical abstract: The discovery of 9/8-ribbons, β/γ-peptides with curved shapes governed by a combined configuration-conformation code
From the themed collection: Foldamers
40 items

About this collection

This themed collection, guest edited by Samuel Gellman and Ivan Huc, is a celebration of current achievements and future perspectives in the exciting field of Foldamers. It is a reflection of the breadth and the potential for development of the subject of folded artificial molecular architectures, covering peptidic foldamers, nucleic acid foldamers, abiotic oligomers, metallofoldamers, protein design and synthesis, folded polymers and their applications. New articles will be added to this collection as they are published.

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