Themed collection Surface Enhanced Raman Spectroscopy

Manipulating the electronic manifold of an organic compound by electrochemical reduction leads to an order of magnitude enhancement of vibrational circular dichroism signals.

Tip-enhanced Raman spectroscopy reveals structural changes of cytochrome c in fixed mitochondria with nanometre resolution. Oxidation and spin-state changes of the heme can be clearly distinguished.

The presence of a magnetic field could lead to reducing electrons on the surface of Ag nanoparticles and a broadened energy gap, which could reduce surface plasma and charge transfer and thus decrease the SERS intensity.

SERS can directly detect the binding of influenza nucleoproteins isolated from a commercial flu vaccine to an anti-influenza aptamer, confirming its applicability to viral diagnostics.

Distributions of the anti-Stokes to Stokes ratios were obtained. The tailed distributions measured in the “single molecule” regime depended on the applied potential and they were correlated to the different resonance energies of the SERRS hot spots.

By combining silver nanoparticles and gold SSV substrates, SERS is obtained from molecules that bridge the particle–cavity gap.

SERS substrates treated by iodide adsorption or electrochemical negative potential desorption provide a good reproducibility for studying living cells.

The sensitive and selective detection of DNA by surface enhanced resonance Raman scattering spectroscopy (SERS) via enzymatic signal release.

The first confirmation of surface enhanced Raman optical activity (SEROA) through measurement of mirror image bands for D- and L-ribose. This was achieved by employing a gel forming polyacrylic acid to control colloidal aggregation and the associated birefringent artefacts.

The orientation of the molecule at the metal nanogap affects the polarization of the Raman scattered photons.

Tri-functional molecules have been synthesised to stabilise Ag nanoparticle cores, act as a resonance Raman reporter and provide a precursor for an integrated network of silica polymers via Stöber condensation.

The surface of a silver colloid has been modified with a mixed thiol monolayer whose composition was tuned to promote MDMA adsorption and thus allow quantitative SERS detection of “Ecstasy”.

Helical silver nanorod arrays are designed by oblique angle deposition and their surface-enhanced Raman scattering properties are characterized. The potential SERS mechanism is proposed.

Surface Enhanced Raman Scattering (SERS) and SERS imaging of Shewanella oneidensis using silver nanoparticles and silver nanowires as metallic substrates.

Gold nanostars covered with a self-assembled monolayer of glycol-modified Raman reporter molecules were used for imaging of the target protein p63 in prostate biopsies.

Resonant SERS-CT intensities have been estimated from the properties of S₀–CT_i transitions of selected [Ag_n–pyridine]^q and [Ag_n–pyrazine]^q complexes.

Quantum mechanical calculations of the ground and excited electronic states of [Ag_n–pyridine]^q complexes yield a linear dependence of the energies of the metal-to-molecule CT_i charge transfer states on q_eff = q/n.

A novel and highly sensitive magnetic separation immunoassay method based on surface enhanced Raman spectroscopy (SERS) has been developed.

Ordered Al nanohole arrays for tunable UV-SERS are theoretically proposed and simulated. The SERS enhancement factor as high as 5 to 6 orders of magnitude is attained in the optimal geometry.

We show that dimers of gold spheres exhibit the largest SERS enhancements at near-IR wavelengths.

Surface selection rules are revealed in the angular and polarization dependence of the SERS signal from Nile Blue molecules on a flat metal film, in the spirit of the original proposal.

In blinking SERRS, truncation in a power-law that reproduces probability distributions of the dark events (P_off) against their duration occurred at the same times despite the change of excitation laser intensity.

SERS imaging on the surface of nanostructured metallic films of controlled morphology uncovers the mechanism generating the SERS background enhancement.

Pillar-like structures created using electron beam lithography are mapped using surface enhance Raman spectroscopy (SERS) and achieve enhancement factors greater than 1 × 10⁹. These novel substrates allow for sensitive real-time analysis of various analytes and are reusable.

LSP/PSP co-enhanced SERS was obtained based on evanescent field excitation and the maximal SERS signal appeared at the SPR angle.

Correlated AFM and Raman imaging provided novel experimental proof that hot spots are located on Ag islands for nanotriangle arrays and in the core area of the hole for nanohole arrays.

Ag nanoparticles with controlled optical properties and biocompatible coatings are used to probe cofactor–protein complexes by SERR spectroscopy. The particles were optimised with respect to maximum signal enhancement and structural preservation of the protein cytochrome c.

Essential nanogap effects on surface-enhanced Raman scattering signals obtained from two diagonally aligned gold nanoparticles with several nanometre separations were elucidated.

SERS nanotags have been prepared to accomplish the multiplex detection of cancer cells. Herein we evaluated the adequacy of lipoic acid-containing cyanine derivatives (Cy3LA and Cy5LA) to function as multiplex partners with triphenylmethine core (B2LA) under single excitation wavelength.

Differential separation of protein mixtures with convective-assembly and detection with SERS.

SERS study of the core–shell structural evolution of Au@Pt nanoparticles: the templating role of the Au atoms on the nanoscale Pt-phase structure in the sub-monolayer range.

New reporter molecules for SERS imaging are accessed via alkyne functionalized nanoparticles and used to image cell surface receptors.

A SERS investigation is combined with ab initio computational analysis for thiazole in Ag hydrosol, where solvation and chemisorption competitively occur.

Silver nanoparticles embedded in the ultrastructure of the pollen outer shell enable vibrational spectroscopic access to the sporopollenin biopolymer.

We develop a simple pathway to prepare effectively SERS-active substrates with Au nanoparticles by an electrochemical strategy of deposition–dissolution cycles.

Our DFT calculations show that surface photocatalytic coupling reactions yield a new surface species of p,p′-dimercaptoazobenzene (DMAB) causing the significant change in the SERS spectra from p-aminothiophenol (PATP) on silver and gold nanogaps.

We find the nontotally symmetric b₂ modes are selectively enhanced in the SERS spectrum and represent a laser wavelength-dependent property.

The first in situ surface Raman spectra of hydrogen on rhodium under electrochemical conditions using Au@Rh and Au@SiO₂ NPs.

Some threshold energy is required for 4-aminobenzenethiol to occupy the chemical enhancement sites on gold.

Detecting a single nanoparticle by TERS gives rise to a Raman spectrum characteristic of the ligand on the nanoparticle and the target protein, enabling nanoscale spectroscopic imaging of protein–ligand binding.

A new and smart approach to get SERS spectra of insoluble compounds. The SERS of quinacridone quinone hosted by calixarenes as a case study.