SCHEDULED MAINTENANCE
Cell-derived matrices for tissue engineering and regenerative medicine applications
This review discusses the development and application of cell-derived matrices (CDM) in cell biology, tissue engineering and regenerative medicine.
Media additives to promote spheroid circularity and compactness in hanging drop platform
Three-dimensional spheroid cultures have become increasingly popular as drug screening platforms, especially with the advent of different high throughput spheroid forming technologies.
Sustained delivery of bioactive neurotrophin-3 to the injured spinal cord
The sustained release of neurotrophin-3 from a nanoparticle/hydrogel composite resulted in functional and tissue benefit after compressive spinal cord injury.
Topographically grooved gel inserts for aligning epithelial cells during air–liquid-interface culture
A moulding based strategy to explore the interplay between various polarization forces in epithelial cells during air liquid interface culture.
Elastomeric nanocomposite scaffolds made from poly(glycerol sebacate) chemically crosslinked with carbon nanotubes
We report fabrication of stiff, elastomeric nanocomposites by covalently crosslinking poly(glycerol sebacate) (PGS) and CNTs for biomedical applications.
The effect of methacrylic acid in smooth coatings on dTHP1 and HUVEC gene expression
Forty percent (but not 20%) methacrylic acid in smooth copolymer films resulted in increased expression of inflammatory and angiogenic genes in dTHP1 cells and migratory genes in HUVEC.
Sub-100 nm patterning of TiO2 film for the regulation of endothelial and smooth muscle cell functions
A sub-100 nm nano-imprinted TiO2 layer significantly inhibited the proliferation of SMCs and increased the proliferation of HUVECs. Focal adhesions size, density and distribution were significantly modulated by nano-imprinted TiO2.
Vasculogenesis and angiogenesis in modular collagen–fibrin microtissues
Vessel networks can be generated within modular protein microbeads containing endothelial cells and fibroblasts. Embedding these microtissues in a surrounding matrix emulates aspects of new blood vessel formation, a process that is critical in tissue development, remodeling, and regeneration.
Presentation modality of glycoconjugates modulates dendritic cell phenotype
The comparative dendritic cell response to glycoconjugates presented in soluble, phagocytosable, or non-phagocytosable display modalities was quantitatively compared in this study.
Angiopoietin-1 peptide QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization on biomedical materials
QHREDGS upregulates osteogenic genes and promotes osteogenesis more effectively than RGDS when immobilized onto titanium medical devices or biomaterials.
Decreased tissue factor expression with increased CD11b upregulation on elastin-based biomaterial coatings
Elastin-like polypeptide (ELP) coatings have been shown to have non-thrombogenic properties. We expand our understanding of this phenomenon here by investigating the interaction of these coatings with leukocytes.
Pharmacokinetics and transgene expression of implanted polyethylenimine-based pDNA complexes
Locally delivered plasmid DNA (pDNA) is currently pursued as gene-based therapy for regenerative medicine, but important information on in situ pDNA pharmacokinetics and transgene expression is lacking in animal models.
About this collection
We are delighted to introduce this collection of articles specially commissioned to mark Michael Sefton’s 65th birthday.
Michael Sefton, University of Toronto, is recognized for seminal contributions to biomaterials science, regenerative medicine and tissue engineering, for development of novel methods for diabetes treatment and for visionary international leadership of the field of biomedical engineering. He has been a leader in the fields of biomaterials, regenerative medicine and tissue engineering for the past 40 years and a source of inspiration for several generations of biomaterials scientists, biomedical engineers, chemical engineers and polymer scientists.
For a full introduction to this themed collection, written by Nicholas A. Peppas (The University of Texas at Austin), please click onto the Biomaterials Science blog: http://rsc.li/1wawmri