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Themed collection Analytical Sciences in the UK

42 items
Open Access Minireview

An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)

New psychoactive substances (NPSs) are a class of compounds that have been recently made available for abuse. Following an unprecedented increase in the number of NPSs in the last 5 years this mini-review overviews this recent emerging research area and the analytical approaches reported.

Graphical abstract: An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)
From the themed collection: Analytical Sciences in the UK
Open Access Minireview

Nano-enabled bioanalytical approaches to ultrasensitive detection of low abundance single nucleotide polymorphisms

A survey of the recent, significant developments on nanomaterials enabled ultrasensitive DNA and gene mutation assays is presented.

Graphical abstract: Nano-enabled bioanalytical approaches to ultrasensitive detection of low abundance single nucleotide polymorphisms
From the themed collection: Analytical Sciences in the UK
Minireview

A short review of applications of liquid chromatography mass spectrometry based metabolomics techniques to the analysis of human urine

Mass spectrometry based metabolomics profiling.

Graphical abstract: A short review of applications of liquid chromatography mass spectrometry based metabolomics techniques to the analysis of human urine
From the themed collection: Hot review articles in Analyst 2015
Minireview

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens

The in vitro identification of volatile biomarkers is the first stage in the development of an exhaled breath test for the identification of a cystic fibrosis pathogen.

Graphical abstract: The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens
From the themed collection: Analytical Sciences in the UK
Open Access Tutorial Review

Chemical analysis of multicellular tumour spheroids

Analytical chemistry applied to 3D tissue culture models.

Graphical abstract: Chemical analysis of multicellular tumour spheroids
From the themed collection: Analytical Sciences in the UK
Open Access Tutorial Review

Calculation of Raman optical activity spectra for vibrational analysis

This review provides the necessary knowledge to accurately model ROA spectra of solvated systems and interpret their vibrational characteristics.

Graphical abstract: Calculation of Raman optical activity spectra for vibrational analysis
From the themed collection: Analytical Sciences in the UK
Tutorial Review

Glyconanoparticles for colorimetric bioassays

This tutorial review focusses on the design and application of glyconanoparticles for the colorimetric detection of lectins, toxins and viruses.

Graphical abstract: Glyconanoparticles for colorimetric bioassays
From the themed collection: Most accessed Analyst articles in 2015
Critical Review

Solution-based nanosensors for in-field detection with the naked eye

Nanomaterials are revolutionising analytical applications with low-cost tests that enable detecting a target molecule in a few steps and with the naked eye.

Graphical abstract: Solution-based nanosensors for in-field detection with the naked eye
From the themed collection: Hot review articles in Analyst 2015
Open Access Critical Review

SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK

The origins of SIFT created to study interstellar chemistry and SIFT-MS developed for ambient gas and exhaled breath analysis and the UK centres in which these techniques are being exploited.

Graphical abstract: SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK
From the themed collection: Analytical Sciences in the UK
Critical Review

Vibrational spectroscopic methods for cytology and cellular research

The use of vibrational spectroscopy, FTIR and Raman, for cytology and cellular research has the potential to revolutionise the approach to cellular analysis.

Graphical abstract: Vibrational spectroscopic methods for cytology and cellular research
From the themed collection: Analytical Sciences in the UK
Open Access Communication

High resolution Raman spectroscopy mapping of stem cell micropatterns

We report on the use of high resolution Raman spectroscopy mapping combined with a micro-engineered stem cell platform.

Graphical abstract: High resolution Raman spectroscopy mapping of stem cell micropatterns
From the themed collection: Analytical Sciences in the UK
Communication

Bacterial meningitis pathogens identified in clinical samples using a SERS DNA detection assay

Application of a SERS DNA detection assay for the identification of bacterial meningitis pathogens in clinical samples.

Graphical abstract: Bacterial meningitis pathogens identified in clinical samples using a SERS DNA detection assay
From the themed collection: Analytical Sciences in the UK
Paper

An integrated ceramic, micro-fluidic device for the LC/MS/MS analysis of pharmaceuticals in plasma

A capillary scale ceramic microfluidic LC/MS/MS system was successfully employed for the analysis of pharmaceutical compounds in plasma.

Graphical abstract: An integrated ceramic, micro-fluidic device for the LC/MS/MS analysis of pharmaceuticals in plasma
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance “Synthacaine

For the first time a novel indirect, independently validated, electrochemical protocol for the sensing of MPA and 2-AI (“Synthacaine”) is reported.

Graphical abstract: Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance “Synthacaine”
From the themed collection: Analytical Sciences in the UK
Paper

Characterising cytotoxic agent action as a function of the cell cycle using fourier transform infrared microspectroscopy

Infrared spectral signatures of drug–cell interaction, suggest that both the stages of proliferation and the degree of apoptosis need to be taken into account to elucidate the fine biochemical details of the immediate cellular response to the drug.

Graphical abstract: Characterising cytotoxic agent action as a function of the cell cycle using fourier transform infrared microspectroscopy
From the themed collection: Analytical Sciences in the UK
Paper

Detection limits of organic compounds achievable with intense, short-pulse lasers

Many organic molecules have strong absorption bands which can be accessed by ultraviolet short pulse lasers to produce efficient ionization.

Graphical abstract: Detection limits of organic compounds achievable with intense, short-pulse lasers
From the themed collection: Analytical Sciences in the UK
Paper

Automated multiwell fluorescence lifetime imaging for Förster resonance energy transfer assays and high content analysis

An HCA-FLIM instrument is presented alongside exemplar oligomerisation, intermolecular and intramolecular FRET assays that require robust measurement of small lifetime changes.

Graphical abstract: Automated multiwell fluorescence lifetime imaging for Förster resonance energy transfer assays and high content analysis
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Application of vibrational spectroscopy techniques to non-destructively monitor plant health and development

Characterisation of plant leaf growth employing vibrational spectroscopy approaches.

Graphical abstract: Application of vibrational spectroscopy techniques to non-destructively monitor plant health and development
From the themed collection: Analytical Sciences in the UK
Paper

Development of a disposable bile acid biosensor for use in the management of cholestasis

Measurement of serum bile acid concentration is a valuable tool for the management of intrahepatic cholestasis of pregnancy (ICP) and is also useful in the monitoring of other liver diseases.

Graphical abstract: Development of a disposable bile acid biosensor for use in the management of cholestasis
Paper

Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin

A novel format of the microtitre plate equipped with magnetic inserts allows rapid and cost-effective development of the controlled release materials.

Graphical abstract: Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin
From the themed collection: Analytical Sciences in the UK
Open Access Paper

A novel method for the analysis of clinical biomarkers to investigate the effect of diet on health in a rat model

We demonstrate differentiation between two diets fed to rats across time via instrumentation combined with multivariate data analysis.

Graphical abstract: A novel method for the analysis of clinical biomarkers to investigate the effect of diet on health in a rat model
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Conformational dynamics of α-synuclein: insights from mass spectrometry

Different mass spectrometry approaches are combined to investigate the conformational flexibility of α-synuclein.

Graphical abstract: Conformational dynamics of α-synuclein: insights from mass spectrometry
From the themed collection: Analytical Sciences in the UK
Paper

Simple preparation of positively charged silver nanoparticles for detection of anions by surface-enhanced Raman spectroscopy

Modification of Ag colloids with thiocholine bromide switches the zeta potential from ca. −50 mV to ca. +50 mV, giving SERS substrates which promote adsorption of anions.

Graphical abstract: Simple preparation of positively charged silver nanoparticles for detection of anions by surface-enhanced Raman spectroscopy
Open Access Paper

Certified ion implantation fluence by high accuracy RBS

1% Implanter Performance: RBS/measured fluence ratio for 16 implants (1015 As cm−2) over 2 years.

Graphical abstract: Certified ion implantation fluence by high accuracy RBS
From the themed collection: Analytical Sciences in the UK
Paper

A step towards mobile arsenic measurement for surface waters

GSH modified QDs are used for selective As3+ measurement for river waters in a mobile phone camera-linked unit.

Graphical abstract: A step towards mobile arsenic measurement for surface waters
From the themed collection: Analytical Sciences in the UK
Paper

Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling

Azidomethyl and cyclooctene dUTPs have been incorporated into DNA by various polymerase enzymes and labelled with cyclooctyne and tetrazine fluorophores.

Graphical abstract: Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Real-world carbon nanoparticle exposures induce brain and gonadal alterations in zebrafish (Danio rerio) as determined by biospectroscopy techniques

Differential tissue-specific effects of nanoparticles: biospectroscopy as a toxicity-sensing tool.

Graphical abstract: Real-world carbon nanoparticle exposures induce brain and gonadal alterations in zebrafish (Danio rerio) as determined by biospectroscopy techniques
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Desalting large protein complexes during native electrospray mass spectrometry by addition of amino acids to the working solution

A simple method for mitigating the adverse effects of salt adduction during native protein mass spectrometry by addition of amino-acids.

Graphical abstract: Desalting large protein complexes during native electrospray mass spectrometry by addition of amino acids to the working solution
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

In this paper we have presented the first example of multiplexing pH and redox responsive SERS nanosensors for intracellular live single cell measurement on a cell by cell basis.

Graphical abstract: Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors
From the themed collection: Analytical Sciences in the UK
Paper

Evaluation of different tissue de-paraffinization procedures for infrared spectral imaging

Differential distribution of paraffin in a normal colon tissue section after various de-Waxing procedures in comparison to a paraffinized tissue.

Graphical abstract: Evaluation of different tissue de-paraffinization procedures for infrared spectral imaging
From the themed collection: Analytical Sciences in the UK
Paper

The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry

This paper describes the development and characterisation of an unmodified hand drawn pencil electrode for the differential pulse anodic stripping voltammetric determination of lead in an environmental water sample.

Graphical abstract: The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry
From the themed collection: Analytical Sciences in the UK
Paper

A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS

This methodology provides increased assay sensitivity and facilitates small volume biofluid analysis in high percent organic samples.

Graphical abstract: A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Making colourful sense of Raman images of single cells

We demonstrate how changes in the application of colour shading can dramatically alter Raman images of single human keratinocytes cells.

Graphical abstract: Making colourful sense of Raman images of single cells
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Novel organic solvents for electrochemistry at the liquid/liquid interface

The 5-nonanone organic phase has been shown to be a stable solvent for use in electrochemistry, ion and electron transfer has been studied at the organic/water interface.

Graphical abstract: Novel organic solvents for electrochemistry at the liquid/liquid interface
From the themed collection: Analytical Sciences in the UK
Paper

Analysis of interaction between the apicomplexan protozoan Toxoplasma gondii and host cells using label-free Raman spectroscopy

Raman micro-spectroscopy was used to characterize time- and spatially-dependent molecular interactions between intracellular pathogens and the host cells.

Graphical abstract: Analysis of interaction between the apicomplexan protozoan Toxoplasma gondii and host cells using label-free Raman spectroscopy
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Development of Transmission Raman Spectroscopy towards the in line, high throughput and non-destructive quantitative analysis of pharmaceutical solid oral dose

Transmission Raman Spectroscopy and photon diode enhancer facilitates faster scanning and quantitative analysis of pharmaceutical tablets.

Graphical abstract: Development of Transmission Raman Spectroscopy towards the in line, high throughput and non-destructive quantitative analysis of pharmaceutical solid oral dose
From the themed collection: Analytical Sciences in the UK
Paper

Real-time microfluidic recombinase polymerase amplification for the toxin B gene of Clostridium difficile on a SlipChip platform

A SlipChip platform with six parallel 500 nL reaction chambers was fabricated using rapid prototyping in acrylic. We demonstrated real-time RPA with 1 fg (1000 copies) of DNA.

Graphical abstract: Real-time microfluidic recombinase polymerase amplification for the toxin B gene of Clostridium difficile on a SlipChip platform
From the themed collection: Analytical Sciences in the UK
Paper

A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers

A comprehensive transmission electron microscopy imaging protocol to characterise in vitro human cell barriers and study mechanisms of nanoparticle transport.

Graphical abstract: A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers
From the themed collection: Most accessed Analyst articles in 2015
Paper

Concentration dependence of translational diffusion coefficients for globular proteins

This investigation examines published results of traditional diffusion experiments on ovalbumin and bovine serum albumin to determine the extent to which assumed concentration independence of the translational diffusion coefficient is a reasonable approximation in the analysis of boundary spreading in sedimentation velocity experiments on proteins.

Graphical abstract: Concentration dependence of translational diffusion coefficients for globular proteins
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Historical textile dyeing with Genista tinctoria L.: a comprehensive study by UPLC-MS/MS analysis

A new UPLC-PDA MS/MS method has been applied to reference and historical yarns dyed with dyer's greenweed (Genista tinctoria L.). The effect of photo-degradation and textile preparation techniques (such as over-dyeing) on the dye fingerprint was investigated and the results correlated with those obtained from historical samples from the Burrell and Bodleian collections, UK.

Graphical abstract: Historical textile dyeing with Genista tinctoria L.: a comprehensive study by UPLC-MS/MS analysis
From the themed collection: Analytical Sciences in the UK
Paper

A smart ink for the assessment of low activity photocatalytic surfaces

New ink for testing low activity photocatalytic materials like self cleaning tiles.

Graphical abstract: A smart ink for the assessment of low activity photocatalytic surfaces
From the themed collection: Analytical Sciences in the UK
Open Access Paper

Switching specific biomolecular interactions on surfaces under complex biological conditions

Electrically switchable surfaces based on oligopeptides are ubiquitous in both switching specific protein interactions in highly fouling media while still offering the non-specific protein-resistance to the surface.

Graphical abstract: Switching specific biomolecular interactions on surfaces under complex biological conditions
From the themed collection: Analytical Sciences in the UK
42 items

About this collection

This collection of articles from Analyst and Analytical Methods , Guest Edited by Duncan Graham and Craig Banks, highlights the excellent research being conducted in the fundamental and applied analytical sciences. Providing a highly visible collection of some of the best and diverse analytical research from UK based scientists in academia, industry and government institutions across disciplines such as chemistry, physics, engineering and clinical sciences.

Spotlight

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