Jump to main content
Jump to site search

Themed collection Recent HOT articles

91 items - Showing page 1 of 2
Communication

An ultrasensitive photoelectrochemical bioanalysis strategy for tumor markers based on the significantly enhanced signal of a bismuth oxyiodine microsphere/graphitic carbon nitride composite

An ultrasensitive PEC bioanalysis strategy was designed based on the significantly enhanced signal of BiOI/g-C3N4 and amplified signal variation of CuS NPs.

Graphical abstract: An ultrasensitive photoelectrochemical bioanalysis strategy for tumor markers based on the significantly enhanced signal of a bismuth oxyiodine microsphere/graphitic carbon nitride composite
From the themed collection: Recent HOT articles
Communication

Time-resolved visual detection of heparin by accelerated etching of gold nanorods

Plasmonic gold nanorods are promising and sensitive light scattering probes, which can reach the single particle level. Herein, we present the scattering properties of gold nanorods for time-resolved visual detection of heparin based on the rapid etching of gold nanorods under dark-field microscopy.

Graphical abstract: Time-resolved visual detection of heparin by accelerated etching of gold nanorods
From the themed collection: Recent HOT articles
Communication

Deducing disulfide patterns of cysteine-rich proteins using signature fragments produced by top-down mass spectrometry

With improved deconvolution and fragment identification strategies, we use the patterns of specific modifications of fragment ions resulted from disulfide cleavage in top-down mass spectrometry to deduce the complex disulfide patterns of cysteine-rich proteins.

Graphical abstract: Deducing disulfide patterns of cysteine-rich proteins using signature fragments produced by top-down mass spectrometry
From the themed collection: Recent HOT articles
Communication

Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

A novel ratiometric fluorescence assay for cerebral Cu2+ has been developed based on coumarin-labeled single-stranded DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine.

Graphical abstract: Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine
From the themed collection: Recent HOT articles
Communication

C–H oxidation and chelation of a dipyrromethane mediated rapid colorimetric naked-eye Cu(II) chemosensor

Selective C–H oxidation and chelation of DPMs mediated by copper is demonstrated and utilized in the development of a rapid colorimetric naked-eye Cu(II) chemosensor.

Graphical abstract: C–H oxidation and chelation of a dipyrromethane mediated rapid colorimetric naked-eye Cu(ii) chemosensor
From the themed collection: Recent HOT articles
Communication

Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

Lipid exchange among citrem nanoparticles and an ethanol micellar solution containing soy phosphatidylcholine was investigated in situ by coupling small angle X-ray scattering with a microfluidic device.

Graphical abstract: Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics
From the themed collection: Recent HOT articles
Paper

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

Aptamers selectively binding to glioblastoma multiforme cells were identified.

Graphical abstract: DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells
From the themed collection: Recent HOT articles
Paper

Highly stable protein immobilization via maleimido-thiol chemistry to monitor enzymatic activity

Combining a novel protein immobilisation method with multivariate curve resolution enables the direct observation of biocatalysis by ATR-FTIR spectroscopy.

Graphical abstract: Highly stable protein immobilization via maleimido-thiol chemistry to monitor enzymatic activity
From the themed collection: Recent HOT articles
Paper

Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)

Key rules for the design of analytical operations based on the transverse solute dispersion in paper are provided.

Graphical abstract: Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)
From the themed collection: Recent HOT articles
Paper

Electrochemical Hg2+ detection at tannic acid-gold nanoparticle modified electrodes by square wave voltammetry

We report the electrochemical sensing of Hg2+ based on tannic acid capped gold nanoparticle (AuNP@TA) complexes.

Graphical abstract: Electrochemical Hg2+ detection at tannic acid-gold nanoparticle modified electrodes by square wave voltammetry
From the themed collection: Recent HOT articles
Paper

A simple and sensitive detection of small molecule–protein interactions based on terminal protection-mediated exponential strand displacement amplification

A new strategy to detect a small molecule–protein interaction was devised based on terminal protection-mediated exponential strand displacement amplification (eSDA).

Graphical abstract: A simple and sensitive detection of small molecule–protein interactions based on terminal protection-mediated exponential strand displacement amplification
From the themed collection: Recent HOT articles
Paper

Graphene-amplified femtosensitive aptasensing of estradiol, an endocrine disruptor

Aptasensing mechanism for femtomolar detection of estradiol [E2], an endocrine disruptor.

Graphical abstract: Graphene-amplified femtosensitive aptasensing of estradiol, an endocrine disruptor
From the themed collection: Recent HOT articles
Paper

Label-free and sensitive detection of Ochratoxin A based on dsDNA-templated copper nanoparticles and exonuclease-catalyzed target recycling amplification

A sensitive method for Ochratoxin A detection was developed which combines the advantages of label-free dsDNA-templated copper nanoparticles and exonuclease-catalyzed recycling amplification.

Graphical abstract: Label-free and sensitive detection of Ochratoxin A based on dsDNA-templated copper nanoparticles and exonuclease-catalyzed target recycling amplification
From the themed collection: Recent HOT articles
Paper

Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas: improving the accuracy of trajectory method calculations

An accurate theoretical collision cross section calculation method in nitrogen was developed for reliable structural ion mobility mass spectrometry.

Graphical abstract: Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas: improving the accuracy of trajectory method calculations
From the themed collection: Recent HOT articles
Paper

First characterization of a biphasic, switch-like DNA amplification

An isothermal, high-gain DNA amplification chemistry with biphasic and switch-like properties.

Graphical abstract: First characterization of a biphasic, switch-like DNA amplification
From the themed collection: Recent HOT articles
Paper

Fluorometric detection of EGFR exon 19 deletion mutation in lung cancer cells using graphene oxide

A sensitive fluorometric detection of EGFR exon 19 deletion mutation based on probe DNA-degrading PCR and graphene oxide.

Graphical abstract: Fluorometric detection of EGFR exon 19 deletion mutation in lung cancer cells using graphene oxide
From the themed collection: Recent HOT articles
Paper

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein–protein interactions

Here protein cross-linking capillary electrophoresis is demonstrated for a wide range of protein–protein interactions including weak and multimeric oligomers.

Graphical abstract: Protein cross-linking capillary electrophoresis at increased throughput for a range of protein–protein interactions
From the themed collection: Recent HOT articles
Paper

Rosamine with pyronine-pyridinium skeleton: unique mitochondrial targetable structure for fluorescent probes

Rosamine-based probes (1a–b) with pyronine-pyridinium skeleton served as mitochondrial targetable probes for detecting independent species (H2O2 and H2S).

Graphical abstract: Rosamine with pyronine-pyridinium skeleton: unique mitochondrial targetable structure for fluorescent probes
From the themed collection: Recent HOT articles
Paper

FTIR spectroscopy of chronic venous leg ulcer exudates: an approach to spectral healing marker identification

Chronic venous leg ulcer arises as a venous insufficiency complication and is a cause of great morbidity.

Graphical abstract: FTIR spectroscopy of chronic venous leg ulcer exudates: an approach to spectral healing marker identification
From the themed collection: Recent HOT articles
Paper

Ultrasensitive chemiluminescence biosensors using nucleic acid-functionalized silver–cysteine nanowires as signal amplifying labels

Ultrasensitive chemiluminescence (CL) sensors for biomolecules (DNA and proteins) have been developed by adopting DNA-functionalized silver–cysteine hybrid nanowires (p-SCNWs) as signal amplifying labels.

Graphical abstract: Ultrasensitive chemiluminescence biosensors using nucleic acid-functionalized silver–cysteine nanowires as signal amplifying labels
From the themed collection: Recent HOT articles
Paper

Development of small particle speciation for nuclear forensics by soft X-ray scanning transmission spectromicroscopy

Synchrotron radiation spectromicroscopy provides a combination of submicron spatial resolution and chemical sensitivity that is well-suited to analysis of heterogeneous nuclear materials.

Graphical abstract: Development of small particle speciation for nuclear forensics by soft X-ray scanning transmission spectromicroscopy
From the themed collection: Recent HOT articles
Open Access Paper

Simultaneous non-polar and polar lipid analysis by on-line combination of HILIC, RP and high resolution MS

Polar and non-polar lipids analysis in 15 min chromatographic run time was enabled by a novel instrumental setup using orthogonal HILIC and RP separation and effluent combination prior to high-resolution mass spectrometry.

Graphical abstract: Simultaneous non-polar and polar lipid analysis by on-line combination of HILIC, RP and high resolution MS
From the themed collection: Recent Open Access Articles
Paper

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

Confocal Raman spectroscopy is an effective method for non-invasive discrimination of 3D human skin equivalents grown under different culture conditions.

Graphical abstract: Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy
From the themed collection: Recent HOT articles
Paper

15N isotopic labelling for in-cell protein studies by NMR spectroscopy and single-cell IR synchrotron radiation FTIR microscopy: a correlative study

The effect of 15N-enrichment on human cells analyzed by correlative in-cell NMR and single-cell SR-FTIR experiments.

Graphical abstract: 15N isotopic labelling for in-cell protein studies by NMR spectroscopy and single-cell IR synchrotron radiation FTIR microscopy: a correlative study
From the themed collection: Recent HOT articles
Paper

Monitoring dynamic spiculation in red blood cells with scanning ion conductance microscopy

Scanning ion conductance microscopy (SICM) is an ideal method to study dynamic phospholipid-induced morphological changes of RBCs in physiological conditions.

Graphical abstract: Monitoring dynamic spiculation in red blood cells with scanning ion conductance microscopy
From the themed collection: Recent HOT articles
Paper

Investigation of compacted DNA structures induced by Na+ and K+ monovalent cations using biological nanopores

Poly(C) single-stranded DNA can be quickly compacted by Na+ or K+ cations in the confined dimension of a biological nanopore.

Graphical abstract: Investigation of compacted DNA structures induced by Na+ and K+ monovalent cations using biological nanopores
From the themed collection: Recent HOT articles
Paper

Quantitative mass spectrometry imaging of glutathione in healthy and cancerous hen ovarian tissue sections by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)

IR-MALDESI quantitative mass spectrometry imaging of glutathione in healthy and cancerous hen ovarian tissues.

Graphical abstract: Quantitative mass spectrometry imaging of glutathione in healthy and cancerous hen ovarian tissue sections by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
From the themed collection: Recent HOT articles
Paper

An improved device with an affinity membrane to collect depth specific contamination free water for environmental assessment

The prime requirement for marine water studies is a competent sampling device that can collect water samples perfectly without any contamination to avoid false analysis.

Graphical abstract: An improved device with an affinity membrane to collect depth specific contamination free water for environmental assessment
From the themed collection: Recent HOT articles
Paper

Implementation of a plasticized PVC-based cation-selective optode system into a paper-based analytical device for colorimetric sodium detection

A classical cation-exchange optode relying on an ionophore-doped plasticized PVC membrane is applied to a paper-based analytical device (PAD) for colorimetric detection of Na+.

Graphical abstract: Implementation of a plasticized PVC-based cation-selective optode system into a paper-based analytical device for colorimetric sodium detection
From the themed collection: Recent HOT articles
Paper

Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry

Sequential and small-scale conformational changes of monoclonal antibodies and antithrombin are characterized in real time in a temperature-controlled fashion.

Graphical abstract: Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry
From the themed collection: Recent HOT articles
Paper

Quantitative evaluation of analyte transport on microfluidic paper-based analytical devices (μPADs)

This work quantitatively evaluates the transport efficiency of analytical target compounds on microfluidic paper-based analytical devices by means of colorimetry and absorption spectrometry.

Graphical abstract: Quantitative evaluation of analyte transport on microfluidic paper-based analytical devices (μPADs)
From the themed collection: Recent HOT articles
Paper

A novel turn-on fluorescent probe for the multi-channel detection of Zn2+ and Bi3+ with different action mechanisms

A novel multifunctional sensor, RSPT, was identified and developed for multichannel turn-on fluorescent responses to Zn2+ and Bi3+ in practice.

Graphical abstract: A novel turn-on fluorescent probe for the multi-channel detection of Zn2+ and Bi3+ with different action mechanisms
From the themed collection: Recent HOT articles
Paper

A tri-site fluorescent probe for simultaneous sensing of hydrogen sulfide and glutathione and its bioimaging applications

Hydrogen sulfide (H2S) and biothiol molecules, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), play an important role in biology.

Graphical abstract: A tri-site fluorescent probe for simultaneous sensing of hydrogen sulfide and glutathione and its bioimaging applications
From the themed collection: Recent HOT articles
Paper

Simultaneous monitoring of different vitrification solution components permeating into tissues

Cryopreservation can be used for long-term preservation of tissues and organs.

Graphical abstract: Simultaneous monitoring of different vitrification solution components permeating into tissues
From the themed collection: Recent HOT articles
Paper

A reversible fluorescent probe based on C[double bond, length as m-dash]N isomerization for the selective detection of formaldehyde in living cells and in vivo

A reversible fluorescent probe for the selective imaging of formaldehyde in living cells, tissues and in vivo.

Graphical abstract: A reversible fluorescent probe based on C [[double bond, length as m-dash]] N isomerization for the selective detection of formaldehyde in living cells and in vivo
From the themed collection: Recent HOT articles
Paper

Hairpin loop-enhanced fluorescent copper nanoclusters and application in S1 nuclease detection

A novel hairpin DNA template with an AT24 double strand stem and a six-base loop was demonstrated for the first time to prepare CuNCs with dramatically enhanced fluorescence and applied for the sensitive detection of S1 nuclease.

Graphical abstract: Hairpin loop-enhanced fluorescent copper nanoclusters and application in S1 nuclease detection
From the themed collection: Recent HOT articles
Paper

On-chip conductometric detection of short DNA sequences via electro-hydrodynamic aggregation

Label-free, conductometric detection of isothermally amplified bacterial DNA was performed in a portable microfluidic system thanks to electro-hydrodynamic aggregation.

Graphical abstract: On-chip conductometric detection of short DNA sequences via electro-hydrodynamic aggregation
From the themed collection: Recent HOT articles
Paper

Revisiting monosaccharide analysis – quantitation of a comprehensive set of monosaccharides using dynamic multiple reaction monitoring

A rapid and sensitive method for the quantitation of monosaccharides using UHPLC/dMRM-MS.

Graphical abstract: Revisiting monosaccharide analysis – quantitation of a comprehensive set of monosaccharides using dynamic multiple reaction monitoring
From the themed collection: Recent HOT articles
Paper

Development of a label-free Raman imaging technique for differentiation of malaria parasite infected from non-infected tissue

This work uses Raman in resonance with Fe-containing porphyrin chromophores to clearly differentiate P. berghei infected & non-infected spleen tissue.

Graphical abstract: Development of a label-free Raman imaging technique for differentiation of malaria parasite infected from non-infected tissue
From the themed collection: Recent HOT articles
Paper

A graphene oxide nanosensor enables the co-delivery of aptamer and peptide probes for fluorescence imaging of a cascade reaction in apoptotic signaling

Cytochrome c (Cyt c) and caspase-3 are the key mediators in apoptotic signaling.

Graphical abstract: A graphene oxide nanosensor enables the co-delivery of aptamer and peptide probes for fluorescence imaging of a cascade reaction in apoptotic signaling
From the themed collection: Recent HOT articles
Paper

An aptamer and functionalized nanoparticle-based strip biosensor for on-site detection of kanamycin in food samples

An aptamer and functionalized nanoparticle-based strip biosensor for highly sensitive and highly specific on-site detection of kanamycin in food samples.

Graphical abstract: An aptamer and functionalized nanoparticle-based strip biosensor for on-site detection of kanamycin in food samples
From the themed collection: Recent HOT articles
Paper

Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy

Drug resistance and heterogeneous characteristics of human gastric carcinoma cells (BGC823) under the treatment of paclitaxel (PTX) were investigated using single-cell Raman spectroscopy (RS).

Graphical abstract: Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy
From the themed collection: Recent HOT articles
Paper

An ionic liquid-magnetic graphene composite for magnet dispersive solid-phase extraction of triazine herbicides in surface water followed by high performance liquid chromatography

A new ionic liquid-magnetic graphene composite was synthesized by a time-saving one-pot strategy for the extraction of triazine herbicides from surface water.

Graphical abstract: An ionic liquid-magnetic graphene composite for magnet dispersive solid-phase extraction of triazine herbicides in surface water followed by high performance liquid chromatography
From the themed collection: Recent HOT articles
Paper

Magnetic bead-based peptide extraction methodology for tissue imaging

MALDI-TOF imaging mass spectrometry (IMS) is a common technique used for analyzing tissue samples, as it allows the user to detect multiple different analytes simultaneously.

Graphical abstract: Magnetic bead-based peptide extraction methodology for tissue imaging
From the themed collection: Recent HOT articles
Paper

Towards the electrochemical diagnostic of influenza virus: development of a graphene–Au hybrid nanocomposite modified influenza virus biosensor based on neuraminidase activity

An effective electrochemical influenza A biosensor based on a graphene–gold (Au) hybrid nanocomposite modified Au-screen printed electrode has been developed.

Graphical abstract: Towards the electrochemical diagnostic of influenza virus: development of a graphene–Au hybrid nanocomposite modified influenza virus biosensor based on neuraminidase activity
From the themed collection: Recent HOT articles
Paper

Rational design of a molecularly imprinted polymer for dinotefuran: theoretical and experimental studies aimed at the development of an efficient adsorbent for microextraction by packed sorbent

In this work, we studied theoretically the formation process of a molecularly imprinted polymer (MIP) for dinotefuran (DNF), by testing distinct functional monomers (FM) in various solvents through density functional theory calculations.

Graphical abstract: Rational design of a molecularly imprinted polymer for dinotefuran: theoretical and experimental studies aimed at the development of an efficient adsorbent for microextraction by packed sorbent
From the themed collection: Recent HOT articles
Paper

Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for the sensitive and specific detection of uracil-DNA glycosylase activity

Uracil removal-inhibited ligase reaction in combination with a catalytic hairpin assembly sensing strategy is demonstrated for UDG activity detection.

Graphical abstract: Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for the sensitive and specific detection of uracil-DNA glycosylase activity
From the themed collection: Recent HOT articles
Paper

High-accuracy and high-sensitivity spectroscopic measurement of dinitrogen pentoxide (N2O5) in an atmospheric simulation chamber using a quantum cascade laser

A spectroscopic instrument based on a mid-infrared external cavity quantum cascade laser was developed for high-accuracy measurements of N2O5 at the ppbv-level.

Graphical abstract: High-accuracy and high-sensitivity spectroscopic measurement of dinitrogen pentoxide (N2O5) in an atmospheric simulation chamber using a quantum cascade laser
From the themed collection: Recent HOT articles
Paper

Dynamic sandwich-type electrochemical assay for protein quantification and protein–protein interaction

A versatile and sensitive electrochemical method for protein–protein interaction study based on DNAzyme has been proposed.

Graphical abstract: Dynamic sandwich-type electrochemical assay for protein quantification and protein–protein interaction
From the themed collection: Recent HOT articles
Paper

A new lateral-flow immunochromatographic strip combined with quantum dot nanobeads and gold nanoflowers for rapid detection of tetrodotoxin

A sensitive, rapid detection strip based on nanoparticles for tetrodotoxin detection was developed and it meets all testing requirements.

Graphical abstract: A new lateral-flow immunochromatographic strip combined with quantum dot nanobeads and gold nanoflowers for rapid detection of tetrodotoxin
From the themed collection: Recent HOT articles
Paper

A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces

Developing a sensitive and accurate method for Furin activity is still the bottleneck for understanding the role played by Furin in cell-surface systems and even in Alzheimer's disease.

Graphical abstract: A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces
From the themed collection: Recent HOT articles
Paper

A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters

A fully integrated cartridge for highly sensitive immunochemical analysis of cardiac markers with new microfluidic functionalities is presented.

Graphical abstract: A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters
From the themed collection: Recent HOT articles
Paper

Deep convolutional neural networks for Raman spectrum recognition: a unified solution

Classification of unprocessed Raman spectra using a convolutional neural network.

Graphical abstract: Deep convolutional neural networks for Raman spectrum recognition: a unified solution
From the themed collection: Recent HOT articles
Paper

Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites

Touch spray mass spectrometry using medical swabs has potential intraoperative application in quickly identifying the disease state of the tissue and in better characterizing resection margins.

Graphical abstract: Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites
From the themed collection: Recent HOT articles
Paper

Microelectrode generator–collector systems for electrolytic titration: theoretical and practical considerations

A novel analysis of generator–collector devices is presented and applied to electrolytic acid–base titration.

Graphical abstract: Microelectrode generator–collector systems for electrolytic titration: theoretical and practical considerations
From the themed collection: Recent HOT articles
Paper

Preparation and application of a poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids in fruit juice and beer samples

A novel poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids.

Graphical abstract: Preparation and application of a poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids in fruit juice and beer samples
From the themed collection: Recent HOT articles
Paper

A single-round selection of selective DNA aptamers for mammalian cells by polymer-enhanced capillary transient isotachophoresis

A single-round DNA aptamer selection for mammalian cells was successfully achieved for the first time using a capillary electrophoresis (CE)-based methodology.

Graphical abstract: A single-round selection of selective DNA aptamers for mammalian cells by polymer-enhanced capillary transient isotachophoresis
From the themed collection: Recent HOT articles
Paper

Alkaline peroxidase activity of cupric oxide nanoparticles and its modulation by ammonia

Based on the ammonia-modulated alkaline peroxidase-like activity of CuO nanoparticles, a fluorescent sensor for urea and urease was developed.

Graphical abstract: Alkaline peroxidase activity of cupric oxide nanoparticles and its modulation by ammonia
From the themed collection: Recent HOT articles
Paper

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

A new penta-saccharide-bearing tripod amphiphile (TPS-E10L) conferred enhanced stability to β2 adrenergic receptor (β2AR) and its Gs complex.

Graphical abstract: New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
From the themed collection: Recent HOT articles
Paper

A ratiometric fluorescent pH probe based on keto–enol tautomerization for imaging of living cells in extreme acidity

A ratiometric fluorescent pH probe (DDXC) has been developed for extreme acidity, the sensing mechanism of which is based on the reversible protonation of the carbonyl oxygen followed by keto–enol tautomerization.

Graphical abstract: A ratiometric fluorescent pH probe based on keto–enol tautomerization for imaging of living cells in extreme acidity
From the themed collection: Recent HOT articles
Paper

Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis

Sensitive analysis of small lipid extracellular vesicles by using a grating-coupled surface plasmon resonance biosensor.

Graphical abstract: Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis
From the themed collection: Recent HOT articles
Paper

Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification

Developing a sensitive and selective sensing platform for the p53 gene and its mutation analysis is essential and may aid in early cancer screening and assessment of prognosis.

Graphical abstract: Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification
From the themed collection: Recent HOT articles
Paper

Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets

The application of machine learning in cancer diagnostics has shown great promise and is of importance in clinic settings.

Graphical abstract: Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets
From the themed collection: Recent HOT articles
Paper

An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening

We have developed a next generation aptamer-based bio-barcode (ABC) assay to detect cytochrome-c (Cyto-c), a cell death marker released from cancer cells, for anti-cancer drug screening.

Graphical abstract: An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
From the themed collection: Recent HOT articles
Paper

Onsite cavity enhanced Raman spectrometry for the investigation of gas exchange processes in the Earth's critical zone

Cavity enhanced Raman spectrometry is a sensitive technique which is capable of continuous onsite analysis of multiple soil gases below-ground.

Graphical abstract: Onsite cavity enhanced Raman spectrometry for the investigation of gas exchange processes in the Earth's critical zone
From the themed collection: Recent HOT articles
Paper

Microchip electrophoresis utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds

A method was developed for the specific entrapment and separation of phosphorylated compounds using a Phos-tag polyacrylamide gel fabricated at the channel crossing point of a microfluidic electrophoresis chip.

Graphical abstract: Microchip electrophoresis utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds
From the themed collection: Recent HOT articles
Paper

A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue

Pneumatically assisted nano-DESI offers improved sensitivity for metabolite species by 1–3 orders of magnitude through more complete desolvation and reduced ionization suppression.

Graphical abstract: A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue
From the themed collection: Recent HOT articles
Paper

An ultrasensitive enzyme-free electrochemical immunosensor based on redox cycling amplification using methylene blue

An enzyme-free immunosensor based on methylene blue redox cycling was developed for ultrasensitive analytical measurements in plasma and whole blood samples.

Graphical abstract: An ultrasensitive enzyme-free electrochemical immunosensor based on redox cycling amplification using methylene blue
From the themed collection: Recent HOT articles
Paper

A model derived from hydrodynamic simulations for extracting the size of spherical particles from the quartz crystal microbalance

A model derived from hydrodynamic simulations is presented for extracting the size of adsorbed nanoparticles in QCM-D measurements, and is applicable to both low and high surface coverage regimes.

Graphical abstract: A model derived from hydrodynamic simulations for extracting the size of spherical particles from the quartz crystal microbalance
From the themed collection: Recent HOT articles
Paper

Spatial and spectral resolution of carbonaceous material from hematite (α-Fe2O3) using multivariate curve resolution-alternating least squares (MCR-ALS) with Raman microspectroscopic mapping: implications for the search for life on Mars

We report a novel application of multivariate analysis with Raman microspectroscopic mapping to enhance the search for life on Mars.

Graphical abstract: Spatial and spectral resolution of carbonaceous material from hematite (α-Fe2O3) using multivariate curve resolution-alternating least squares (MCR-ALS) with Raman microspectroscopic mapping: implications for the search for life on Mars
From the themed collection: Recent HOT articles
91 items - Showing page 1 of 2

About this collection

This collection represents the top 10% of research published in Analyst in the last couple of years. Featured articles are marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured

Spotlight

Advertisements