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Book cover

Chemical Biology of Glycoproteins Editors: Zhongping Tan, Lai-Xi Wang


Print publication date: 27 Mar 2017
Copyright year: 2017
Print ISBN: 978-1-78262-333-5
PDF eISBN: 978-1-78262-382-3
ePub eISBN: 978-1-78801-122-8
Citation:

About this book

Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions.

Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.