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Book cover

Inhibitors of Molecular Chaperones as Therapeutic Agents Editors: Timothy D Machajewski, Zhenhai Gao



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This book contains 352 pages.
Print publication date: 30 Oct 2013
Copyright year: 2013
Print ISBN: 978-1-84973-666-4
PDF eISBN: 978-1-84973-968-9
Citation:

About this book

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.


Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.

From the book series:
RSC Drug Discovery