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Acute Brain Impairment: Scientific Discoveries and Translational Research Editors: Philip V Peplow, Svetlana A Dambinova, Thomas A Gennarelli, Bridget Martinez


About this book

A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific advancements in these areas.

Chapters provide the latest knowledge in neuroscience, biotechnology, and personalized medicine applicable to acute brain injuries. Development of neuroprotective drugs is treated in detail. Chemical biomarkers for detection, imaging and preventative strategies are covered to provide medicinal chemists with a broad view of translational aspects of the field.

This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.

From the book series:
Drug Discovery

Book content

  • TIA, TBI and ischemic stroke, and risk factors
  • Inflammatory changes in cerebral ischemic injury: cellular and molecular involvement
  • Biomarkers of acute brain injury and surrogate endpoints in TBI and stroke translational studies
  • Difficulties of translating outcomes from animal studies to clinical trials
  • Neuroprotective therapies for ischemic stroke
  • The molecular strategies in cerebral ischemia: An insight into emerging treatment for oxidative stress
  • Identification of microRNAs as targets for treatment of ischemic stroke
  • Drug-test co-development strategy
  • Advances in diagnostics and treatment of neurotoxicity after sports related injuries
  • Functional predictors for prognosis and recovery after unconsciousness due to mild TBI
  • Predictors for prognosis and recovery from unconsciousness due to brain trauma
  • Neurotoxicity in cerebral and spinal cord ischemia
  • Advanced approaches in stem cell replacement for stroke and TBI
  • Testing and mechanisms of neuroprotective agents for cerebral ischemic injury in clinical trials 2010-2016
  • Difficulties in clinical trials to treat TBI and stroke
  • Challenges in stroke biomarkers testing
  • Stroke biomarkers incorporated in clinical decision-making
  • Development of novel test platforms for assessment of brain injury
  • Advancements and challenges in hyperacute stroke translational research

The print version of this book is planned for release on 05 December 2017. Information about this book is subject to change without notice.

Pre-order hardback £149.00 *
* Exclusive of taxes
This book contains 358 pages.

Publication details

Copyright year: 2018
Print ISBN: 978-1-78262-950-4
Citation: