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Biophysical Techniques in Drug Discovery Editor: Angeles Canales

About this book

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays.
This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery.
This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

From the book series:
Drug Discovery

Book content

  • Impact and Evolution of Biophysics in Medicinal Chemistry
  • Ligand-Detected NMR Methods in Drug Discovery
  • Receptor based NMR techniques in Drug Discovery
  • Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design
  • Mass Spectrometry in Biophysics: from High Throughput Screening to Structural Biology
  • Characterization of Pharmaceutical Solids Combining NMR, X-ray Diffraction and Computer Modelling
  • Surface Plasmon Resonance for Identifying and Characterising Small Molecule Ligands
  • Fluorescent Thermal Shift Assays for Identifying Small Molecule Ligands
  • Fluorescent Probes in Medicinal Chemistry
  • Transmission Cryo-Electron Microscopy in Drug Discovery
  • Molecular Imaging
  • Subject Index

The print version of this book is planned for release on 13 November 2017. Information about this book is subject to change without notice.

Pre-order hardback £159.00 *
* Exclusive of taxes
This book contains 306 pages.

Publication details

Copyright year: 2018
Print ISBN: 978-1-78262-733-3