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Solid-State NMR Studies of β-Amyloid Fibrils and Related Assemblies

The β-amyloid (Aβ) peptide forms a variety of fibrillar and non-fibrillar assemblies in human brain tissue, especially in Alzheimer's disease (AD). Over the past 20 years, solid-state NMR methods have played a major role in the elucidation of the molecular structures of Aβ assemblies. This chapter reviews progress in this research area, including structural studies of fibrils formed by Aβ fragments, full-length Aβ peptides, and disease-associated mutants, as well as studies of Aβ oligomers and protofibrils, Aβ/membrane interactions, and interactions of Aβ with metal ions.

Print publication date: 06 Mar 2014
Copyright year: 2014
Print ISBN: 978-1-84973-910-8
PDF eISBN: 978-1-78262-744-9
ePub eISBN: 978-1-78262-119-5
From the book series:
New Developments in NMR