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CHAPTER 8

Structural Studies of Small Bioactive Compounds Interacting with Membranes and Proteins

This review describes the brief theory and some applications of solid-state NMR techniques that are frequently used for small compounds, including membrane lipids and drugs. We further focus on intermolecular interactions in dynamic systems that are not usually obtainable by X-ray crystallographic structures. In particular, recent studies on the structures and interactions of small bioactive compounds in membranes are reviewed in more detail because they often exert their action in a membrane-bound form. In addition, small compounds that interact with protein aggregates and polymeric proteins, such as amyloids and tubulin, are examined.

Print publication date: 06 Mar 2014
Copyright year: 2014
Print ISBN: 978-1-84973-910-8
PDF eISBN: 978-1-78262-744-9
ePub eISBN: 978-1-78262-119-5
Citation:
From the book series:
New Developments in NMR