Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).
During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.
The main components of mammalian tissue, after water, are lipids. Both xenon (Xe) and cryptophane-A (CrA), which acts as a molecular host for Xe, preferentially embed into lipid environments. These environments generate a large chemical shift difference (∼10 ppm) of the Xe@CrA complex compared to it being in aqueous solution. In this chapter, we describe how membrane models can easily be prepared and demonstrate the detection of Xe@CrA complexes interacting with such membrane models using the selectivity of Hyper-CEST NMR. Additionally, we review how Hyper-CEST spectroscopy and MRI can be used to obtain information about the membrane’s constituents and their phase properties and compare the Hyper-CEST responses of membrane models to the ones of cells.