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Formulating Nanoparticles to Achieve Oral and Intravenous Delivery of Challenging Drugs

Nanoparticles were found suitable materials to transport drugs in vivo. Their application as drug carrier by intravenous and oral routes of administration generally improves efficiency of treatments with existing molecules. Their use makes possible the development of treatments with challenging new molecules displaying a high therapeutic potential such as nucleic acids, proteins and peptides. Success of drug delivery methods using nanoparticles is greatly influenced by the ability of the drug carrier to cross biological barriers and by the specificity of its biodistribution. The aim of this review was to present few aspects of the formulation of nanoparticles designed for the delivery of drugs by the oral route and by intravenous injections. It focuses on strategies developed to design surface properties of the nanoparticles. The rational behind this choice is that surface properties were identified as a major parameter influencing the in vivo fate of nanoparticles. Specific examples were taken from developments made on poly(alkylcyanoacrylate) nanoparticles. This review shows that formulation strategies are closely linked with biological phenomena governing interactions between nanoparticles and the host. It indicated that nanoparticle surface properties need to be finely tuned to achieve the desired properties and that all surface modifications can be performed by an appropriate chemistry.

Print publication date: 04 Apr 2012
Copyright year: 2012
Print ISBN: 978-1-84973-378-6
PDF eISBN: 978-1-84973-524-7