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Contemporary glycoconjugation chemistry

Glycoproteins are typically expressed in nature with heterogeneous glycan components; understanding glycoprotein structure–function relationships is therefore challenging. This has been the driving force for increasing investigation for glycoconjugation techniques, in order to access homogenous natural glycoproteins and analogues thereof. These tools will be invaluable in efforts to unveil the precise role of each glycan structure. This mini-review provides a critical survey of glycoconjugation methodologies, with an emphasis on more recent progress in the field. Chemical and chemo-enzymatic glycoconjugation methods will be described, along with illustrations of typical applications.

Print publication date: 31 Oct 2016
Copyright year: 2017
Print ISBN: 978-1-78262-538-4
PDF eISBN: 978-1-78262-665-7
ePub eISBN: 978-1-78262-974-0