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CHAPTER 6

Asymmetric Friedel–Crafts Alkylation Reactions

The asymmetric Friedel–Crafts (AFC) alkylation reaction is one of the most important approaches to the synthesis of optically pure organic compounds. Various catalytic systems, including well-defined organometallic complexes (Zn, Cu, Sc, etc.) and small organic molecules (chiral imidazolidinones, thioureas, prolinols, BINOL-derived phosphoric acids, etc.), have been successfully developed and applied in asymmetric Friedel–Crafts alkylation reactions. Remarkable levels of enantioselectivity have been achieved for electron-rich arenes such as indoles, pyrroles, and naphthols, and electrophiles such as carbonyl compounds, imines, α,β-unsaturated carbonyl compounds, and π-allyl metal species.

Print publication date: 13 Aug 2015
Copyright year: 2015
Print ISBN: 978-1-78262-102-7
PDF eISBN: 978-1-78262-196-6
ePub eISBN: 978-1-78262-654-1
Citation:
From the book series:
Catalysis Series