Issue 10, 2024

Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

Abstract

This study reports efforts toward the integrated advanced manufacturing of the anti-narcoleptic drug modafinil. It showcases a holistic approach from flow synthesis to purification via continuous crystallization. The integration strategy included a necessary optimization of the reported flow synthesis for modafinil, enabling prolonged operation and consistent crude quality. The reactor effluents were subsequently processed downstream for purification utilizing two single stage mixed suspension mixed product removal crystallizers. The first stage was an antisolvent cooling crystallization, providing refined modafinil with >98% yield. The second cooling crystallization delivered crystalline modafinil with >99% purity in the required polymorphic form I suitable for formulation.

Graphical abstract: Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

Supplementary files

Article information

Article type
Paper
Submitted
05 Jun 2024
Accepted
29 Jul 2024
First published
08 Aug 2024

React. Chem. Eng., 2024,9, 2728-2739

Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

D. V. Silva-Brenes, S. Agrawal, V. López-Mejías, J. Duconge, C. P. Vlaar, J. M. Monbaliu and T. Stelzer, React. Chem. Eng., 2024, 9, 2728 DOI: 10.1039/D4RE00273C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements