Palladium-catalyzed 1,2-selective intermolecular arylamination of 1,3-dienes

Abstract

Transition metal-catalyzed transformations of 1,3-dienes have always been an important research topic for chemists, but highly selective intermolecular 1,2-arylamination of 1,3-dienes has not been reported. In this study, we present a method for the palladium-catalyzed 1,2-difunctionalization of conjugated dienes. This approach offers an efficient pathway for the 1,2-selective arylamination of 1,3-dienes, demonstrating remarkable chemo- and regioselectivity, as well as a broad substrate scope and excellent functional group tolerance. Furthermore, this method shows compatibility with the late-stage functionalization of drug molecules and has the potential for scalable production, underscoring its synthetic utility for practical applications in organic synthesis.