Nickel-catalysed C–N cross-coupling of organoboronic acids and isoxazoles

Abstract

A nickel-catalysed C–N cross-coupling of organoboronic acids and isoxazoles has been established for the efficient synthesis of (Z) N-aryl β-enamino esters. 5-Alkoxy/phenoxy isoxazoles serve as reliable aminating reagents in this transformation through N–O bond cleavage. A wide range of N-aryl β-enamino esters (32 examples in up to 93% yields) with different functional groups were synthesized through this method under mild reaction conditions.