Issue 15, 2024

Direct C–H sulfonylation of hydrazones involving the insertion of SO2

Abstract

A three-component reaction of aldehyde-derived hydrazones with DABSO and aryldiazonium tetrafluoroborates is described. By using organic DABSO as the source of SO2, this straightforward sulfonylation tactic provides an elegant access to (E)-sulfonylated hydrazones in moderate to excellent yields. Moreover, the sulfonylation of hydrazones can also be achieved under photocatalyzed conditions by using sulfonyl chlorides as the active sulfonylating reagents.

Graphical abstract: Direct C–H sulfonylation of hydrazones involving the insertion of SO2

Supplementary files

Article information

Article type
Research Article
Submitted
10 May 2024
Accepted
14 Jun 2024
First published
17 Jun 2024

Org. Chem. Front., 2024,11, 4284-4289

Direct C–H sulfonylation of hydrazones involving the insertion of SO2

M. Yu, S. Lin, S. Zhang, X. Lin and X. Huang, Org. Chem. Front., 2024, 11, 4284 DOI: 10.1039/D4QO00835A

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