Issue 12, 2024

Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

Abstract

Regioselective C–H functionalization of aromatics remains a challenging problem in organic synthesis, particularly for meta-selective C–H borylations of phenols derivatives. Here, pivalic acid promoted iridium-catalyzed meta-selective C–H borylation of phenols is disclosed. Various substituted phenol directives including bioactive compounds are found to be tolerated, affording the corresponding borylated products in moderate to good yields under concise reaction conditions.

Graphical abstract: Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
20 Mar 2024
Accepted
25 Apr 2024
First published
27 Apr 2024

Org. Chem. Front., 2024,11, 3409-3414

Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

W. Ju, D. Gao, M. Liang, S. Han, C. Liu and Y. Zhao, Org. Chem. Front., 2024, 11, 3409 DOI: 10.1039/D4QO00516C

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