Oxidative cascade cyclization of N-arylacrylamides with TMSN3†
Abstract
An azido-radical-triggered cyclization of N-(o-cyanobiaryl)acrylamides with TMSN3via a C(sp3)–N/C(sp2)–C(sp3)/C(sp2)–N bond formation cascade is described. This reaction features mild conditions and high bond-forming efficiency, making it an efficient method for the construction of azide-substituted pyridophenanthridines.