The construction of novel pyrrole-4H-chromene-embedded vinyl sulfonyl fluorides via a three-component process

Abstract

A synthetic strategy involving salicylaldehyde, 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF), and pyrrole has been developed to construct novel pyrrole-4H-chromene-embedded vinyl sulfonyl fluoride derivatives with exclusive regioselectivity. This method exhibits moderate to excellent yields (45–93%) and showcases a wide substrate scope with excellent functional group compatibility. Additionally, the resulting sulfonyl fluorides were further diversified via sulfur fluoride exchange (SuFEx) reactions to produce sulfonates and sulfonamides, which are valuable structural motifs in medicinal chemistry.