Issue 6, 2024

Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach

Abstract

Pulmonary hypertension (PH), characterised by mean pulmonary arterial pressure (mPAP) >20 mm Hg at rest, is a complex pathophysiological disorder associated with multiple clinical conditions. The high prevalence of the disease along with increased mortality and morbidity makes it a global health burden. Despite major advances in understanding the disease pathophysiology, much of the underlying complex molecular mechanism remains to be elucidated. Lack of a robust diagnostic test and specific therapeutic targets also poses major challenges. This review provides a comprehensive update on the dysregulated pathways and promising candidate markers identified in PH patients using the transcriptomics and metabolomics approach. The review also highlights the need of using an integrative multi-omics approach for obtaining insight into the disease at a molecular level. The integrative multi-omics/pan-omics approach envisaged to help in bridging the gap from genotype to phenotype is outlined. Finally, the challenges commonly encountered while conducting omics-driven studies are also discussed.

Graphical abstract: Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach

Article information

Article type
Review Article
Submitted
23 Dec 2023
Accepted
20 May 2024
First published
21 May 2024

Mol. Omics, 2024,20, 366-389

Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach

P. Choudhury, S. Dasgupta, P. Bhattacharyya, S. Roychowdhury and K. Chaudhury, Mol. Omics, 2024, 20, 366 DOI: 10.1039/D3MO00266G

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